Electrical Changes in Polish Patients with Chronic Heart Failure: Preliminary Observations

Sobieszek, Grzegorz; Mlak, Radosław; Skwarek-Dziekanowska, Aneta; Jurzak-Myśliwy, Aneta; Homa‐Mlak, Iwona; Małecka‐Massalska, Teresa

doi:10.3390/medicina55080484

Cited by 15 publications

(15 citation statements)

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“…Four standard electrodes attached to the right hand and foot were used. In all patients, measurements were performed in triplicate (then mean values were calculated) in similar conditions (in the morning, on an empty stomach, after 5 minutes lying on the back to equalize a body level of fluids) [ 15 ]. In the study group, 42% of participants were >65 years old.…”

Section: Methodsmentioning

confidence: 99%

High Level of Irisin as a Marker of Malnutrition in Head and Neck Cancer Patients Subjected to Radiotherapy

et al. 2022

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Background Head and neck cancers (HNC) are the 7 th most prevalent neoplasms in the world. In 50% of these patients, body weight loss and malnutrition are observed before the beginning of therapy. It is known that an important role in the pathomechanism of malnutrition and cachexia is played by the development of inflammation, degradation of muscle fibers, and browning of white adipose tissue (WAT). It was demonstrated that even a slight increase in irisin concentration leads to browning of WAT. Material/Methods The study group consisted of 50 patients with HNC. The nutritional status of the patients was assessed by the Nutritional Risk Score 2002 (NRS 2002) and Subjective Global Assessment (SGA) scales. Using bioelectrical impedance analysis (BIA), the parameters fat mass (FM) and fat-free mass (FFM) were obtained. Results Higher irisin values (1.57 vs 1.18 [ng/ml], P =0.0004) were observed in patients with higher nutritional risk (≥3) evaluated according to the NRS scale. In patients assessed as B or C on the SGA scale, higher values of irisin concentration (1.38 vs 1.07 [ng/ml], P =0.0139) were noted. It was also observed that the level of irisin before treatment was negatively correlated (rho=−0.30, p =0.0350) with FM% and was positively correlated (rho=0.30, p =0.0340) with FFM% in BIA measurements performed after the 7 th cycle of RTH. Conclusions Based on these results, we conclude that patients with malnutrition tend to have higher irisin values compared to normally nourished patients. A high level of irisin may be a useful marker of malnutrition in patients with HNC.

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Section: Methodsmentioning

confidence: 99%

High Level of Irisin as a Marker of Malnutrition in Head and Neck Cancer Patients Subjected to Radiotherapy

et al. 2022

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“…Frequencies of 5, 50, 100, and 200 kHz. N/A HFrEF (P between NYHA groups: 0.04) Men NYHA class I-II: 5.7 ± 1.2° vs. NYHA class III-IV: 4.9 ± 0.9° Women NYHA class I-II: 5.1 ± 0.7° vs. NYHA class III-IV: 4.2 ± 1.9° HFpEF (P between NYHA groups: 0.01) Men NYHA class I-II: 5.8 ± 1.1° vs. NYHA class III-IV: 4.8 ± 1.1° Women NYHA class I-II: 4.9 ± 1.3° vs. NYHA class III-IV: 4.2 ± 1.0° HFrEF Men 0.8° Women 0.9° HFpEF Men 1.0° Women 0.7° Sobieszek et al 2019 [ 46 ] 100 52 NYHA class I-II 48 NYHA class III-IV Cross-sectional ImpediMed bioimpedance analysis SFB7 BioImp v1.55 (PinkenbaQld 4008, Australia). N/A PhA NYHA class I-II 4.49° (2.80° – 7.19°) vs. NYHA class III-IV 2.95° (1.50° – 6.65° ), p = 0.01 1.54° Scicchitano et al 2020 [ 18 ] 900 ADHF and CHF patients Retrospective CardioEFG, Akern RJL Systems, Florence, Italy Tetrapolar impedance plethysmograph, 50 kHz alternating sinusoidal current N/A Congestion biomarkers explained the 34% of PhA variability: 20% by PVS, 10% by peripheral congestion; 2% by BNP, respectively Age, GNRI, and only explained 6%, 0.5%, and 0.5% of PhA variability, respectively González-Islas et al 2020 [ 51 ] 288 Stable HF patients Prospective cohort Tetrapolar and multi-frequency equipment (Body Stat Quad Scan 4000).…”

Section: Bioelectrical Phase Angle: Definition and Characteristicsmentioning

confidence: 99%

The role of bioelectrical phase angle in patients with heart failure

Scicchitano¹,

Massari²

2022

Rev Endocr Metab Disord

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The most challenging feature of heart failure (HF) still remains the evaluation of congestion. Residual congestion at discharge and the difficulties in perfectly dosing therapies in order to balance the hydration status of the patient are the most worrisome issues when dealing with HF. The use of bioimpedance vector analysis (BIVA) might promote a different approach in the general management of patients with HF. BIVA is a reliable, fast, bedside tool able to assess the congestion status. It proved to be helpful to physicians for diagnosing congestive status, managing therapies, and providing prognostic information in the setting of HF. Bioelectrical Phase Angle (PhA) – as derived from equations related to the parameters of BIVA – recently surged as a possible biomarker for patients with HF. Studies provided data about the application of PhA in the clinical management and in the overall risk stratification of HF patients. Basically, the use of PhA might be considered as a holistic evaluation of patients with HF which includes the need for a multiparametric approach able to effectively depict the clinical status of patients. There is no definite biomarker able to comprehensively describe and identify all the features of HF patient, but scores based on molecules/techniques able to explore the different pathogenetic mechanisms of HF are desirable. The aim of this review was to provide a comprehensive evaluation of literature related to PhA role in HF and the impact of this biomarker on clinical management and risk stratification of HF patients.

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“…The factors associated with the growing number of newly diagnosed cases of CHF are: age (> 70 years) and concomitant diastolic heart failure. As a result of metabolic, anabolic and catabolic disorders associated with CHF, a large number of patients with suspected CHF are diagnosed with left ventricular dysfunction 1 , 2 .…”

Section: Introductionmentioning

confidence: 99%

Polymorphism of the ITGAM gene (rs7193943) and bioelectric impedance analysis as potential predictors of cachexia in chronic heart failure

Sobieszek

Mlak

Powrózek

et al. 2021

Sci Rep

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Cardiac cachexia (CC) is an unfavorable metabolic syndrome leading to exacerbation of chronic heart failure (CHF) and a higher risk of death. The main factor contributing to the development of cachexia is the ongoing inflammatory process mediated by genes (e.g. Integrin Subunit Alpha M—ITGAM). The study aimed to assess the relationship between a single nucleotide polymorphism (SNP) -323G > A of the ITGAM and the occurrence of nutritional disorders in patients with CHF. 157 CHF patients underwent clinical and nutritional screening. Body composition was evaluated by bioelectrical impedance analysis (BIA). Patients with cachexia were characterized by significantly lower weight, body mass index (BMI), lower fat mass (FM), albumin, and hemoglobin. Lower values of BIA parameters: capacitance of membrane (Cm), phase angle (PA), and impedance ratio (Z200/Z5) were noted in women. Those patients demonstrated significantly higher values of creatinine, c-reactive protein (CRP), N-terminal prohormone of brain natriuretic peptide (NT-proBNP), and pulmonary artery systolic pressure (PASP). A significantly higher risk of cachexia was reported in patients: aged ≥ 74 years (OR 3.55), with renal failure (OR 3.75), New York Heart Association classification (NYHA) III-IV (OR 2.83), with moderate or severe malnutrition according to the score of subjective global assessment (SGA) (OR 19.01) and AA genotype of ITGAM gene (OR 2.03). Determination of the -323G > A SNP in the ITGAM may prove to be a useful marker (after confirmation in further studies and appropriate validation) in the assessment of the risk of nutritional disorders in patients with CHF.

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Electrical Changes in Polish Patients with Chronic Heart Failure: Preliminary Observations

Cited by 15 publications

References 38 publications

High Level of Irisin as a Marker of Malnutrition in Head and Neck Cancer Patients Subjected to Radiotherapy

High Level of Irisin as a Marker of Malnutrition in Head and Neck Cancer Patients Subjected to Radiotherapy

The role of bioelectrical phase angle in patients with heart failure

Polymorphism of the ITGAM gene (rs7193943) and bioelectric impedance analysis as potential predictors of cachexia in chronic heart failure

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