Electrical Block of Peripheral Nerves

Eggers, Thomas E.; Green, David B.; Vrabec, Tina; Kilgore, Kevin L.; Bhadra, Niloy

doi:10.1007/978-981-15-2848-4_63-1

Cited by 2 publications

(2 citation statements)

References 85 publications

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“…Additionally, owing to the direct link between the electrical signal and the muscular strength, the muscular chains may also be stimulated by external electrical signals using active electrodes, thus forcing muscular contraction. Among a wide variety of applications, this may be used to determine the origin of fatigue as peripheral [29] or central [30]. In any case, correct electrode placement is critical for achieving satisfactory results [31].…”

Section: A Physical Fatiguementioning

confidence: 99%

A Comprehensive Study of Human Factors, Sensory Principles, and Commercial Solutions for Future Human-Centered Working Operations in Industry 5.0

et al. 2023

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The purpose of this study is to explore the measurement of human factors in the workplace that can provide critical insights into workers' well-being. Human factors refer to physical, cognitive, and psychological states that can impact the efficiency, effectiveness, and mental health of workers. The article identifies six human factors that are particularly crucial in today's workplaces: physical fatigue, attention, mental workload, stress, trust, and emotional state. Each of these factors alters the human physiological response in a unique way, affecting the human brain, cardiovascular, electrodermal, muscular, respiratory, and ocular reactions. This paper provides an overview of these human factors and their specific influence on psycho-physiological responses, along with suitable technologies to measure them in working environments and the currently available commercial solutions to do so. By understanding the importance of these human factors, employers can make informed decisions to create a better work environment that leads to improved worker well-being and productivity.INDEX TERMS Human factors, industry 5.0, psycho-physiological signals, human physical and cognitive states, signal acquisition, measuring techniques, human-in-the-loop, industrial applications.

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Section: A Physical Fatiguementioning

confidence: 99%

A Comprehensive Study of Human Factors, Sensory Principles, and Commercial Solutions for Future Human-Centered Working Operations in Industry 5.0

et al. 2023

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“…One characteristic that might compromise the use of KHFAC in clinical setting is an initial nerve activation, before complete block occurs, called the "onset response. " Several methods are being developed to avoid/diminish the onset response, as for example the use of rampamplitudes (Vrabec et al, 2019); the combination of direct current and KHFAC (Eggers et al, 2021); optimization of KHFAC waveforms to produce closed-state Na + channel inactivation (Yi and Grill, 2020); as well as the use of higher KHFAC amplitudes and frequencies (Gerges et al, 2010). In agreement, we have been able to block CSN activity specifically at 40-50 kHz, 1-2 mA without causing an abnormal physiological onset response (Table 1; Sacramento et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Bioelectronic modulation of carotid sinus nerve to treat type 2 diabetes: current knowledge and future perspectives

Conde,

Sacramento,

Zinno

et al. 2024

Front. Neurosci.

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Bioelectronic medicine are an emerging class of treatments aiming to modulate body nervous activity to correct pathological conditions and restore health. Recently, it was shown that the high frequency electrical neuromodulation of the carotid sinus nerve (CSN), a small branch of the glossopharyngeal nerve that connects the carotid body (CB) to the brain, restores metabolic function in type 2 diabetes (T2D) animal models highlighting its potential as a new therapeutic modality to treat metabolic diseases in humans. In this manuscript, we review the current knowledge supporting the use of neuromodulation of the CSN to treat T2D and discuss the future perspectives for its clinical application. Firstly, we review in a concise manner the role of CB chemoreceptors and of CSN in the pathogenesis of metabolic diseases. Secondly, we describe the findings supporting the potential therapeutic use of the neuromodulation of CSN to treat T2D, as well as the feasibility and reversibility of this approach. A third section is devoted to point up the advances in the neural decoding of CSN activity, in particular in metabolic disease states, that will allow the development of closed-loop approaches to deliver personalized and adjustable treatments with minimal side effects. And finally, we discuss the findings supporting the assessment of CB activity in metabolic disease patients to screen the individuals that will benefit therapeutically from this bioelectronic approach in the future.

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Electrical Block of Peripheral Nerves

Cited by 2 publications

References 85 publications

A Comprehensive Study of Human Factors, Sensory Principles, and Commercial Solutions for Future Human-Centered Working Operations in Industry 5.0

A Comprehensive Study of Human Factors, Sensory Principles, and Commercial Solutions for Future Human-Centered Working Operations in Industry 5.0

Bioelectronic modulation of carotid sinus nerve to treat type 2 diabetes: current knowledge and future perspectives

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