Electrical activity of neurons in the ventrolateral septum and bed nuclei of the stria terminalis in suckled rats: Statistical analysis gives evidence for sensitivity to oxytocin and for relation to the milk-ejection reflex

Lambert, Régis C.; Moos, Françoise; Ingram, C.D.; Wakerley, J. B.; Krémarik, P.; Guerné, Y.; Richard, Ph.

doi:10.1016/0306-4522(93)90258-h

Cited by 36 publications

(11 citation statements)

References 43 publications

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“…There is a dense noradrenergic projection to the BNST where noradrenaline is released . Stimulation of the BNST (with oxytocin) facilitates bursting in oxytocin MNCs in the SON and the cyclical activity of BNST neurones is correlated with milk‐ejection bursts in oxytocin MNCs , suggesting that the BNST might also be involved in gating milk ejection bursts.…”

Section: Afferent Inputs To Mncsmentioning

confidence: 99%

Physiological Regulation of Magnocellular Neurosecretory Cell Activity: Integration of Intrinsic, Local and Afferent Mechanisms

Brown

Bains

Ludwig

et al. 2013

J Neuroendocrinology

142

133

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The hypothalamic supraoptic and paraventricular nucleus contain magnocellular neurosecretory cells (MNCs) that project to the posterior pituitary gland where they secrete either oxytocin or vasopressin (the anti-diuretic hormone) into the circulation. Oxytocin is important for delivery at birth and is essential for milk ejection during suckling. Vasopressin primarily promotes water reabsorption in the kidney to maintain body fluid balance, but also increases vasoconstriction. The profile of oxytocin and vasopressin secretion is principally determined by the pattern of action potentials initiated at the cell bodies. While it has long been known that the activity of MNCs depends upon afferent inputs that relay information on reproductive, osmotic and cardiovascular status, it has recently become clear that activity depends critically on local regulation by glial cells, as well as intrinsic regulation by the MNCs themselves. Here, we provide an overview of recent advances in our understanding of how intrinsic and local extrinsic mechanisms integrate with afferent inputs to generate appropriate physiological regulation of oxytocin and vasopressin MNC activity.

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Section: Afferent Inputs To Mncsmentioning

confidence: 99%

Physiological Regulation of Magnocellular Neurosecretory Cell Activity: Integration of Intrinsic, Local and Afferent Mechanisms

Brown

Bains

Ludwig

et al. 2013

J Neuroendocrinology

142

133

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show abstract

“…190 Interesting, none of the antidromically activated BNST neurons from PVN stimulation were affected by OT. 191 Thus the BNST remains a site of interest as a target for central OT actions facilitating the reflex, but it would appear the output of the OT-excited BNST neurons is probably polysynaptic to OT milk ejection neurons, and the overall importance of this structure to the reflex per se is unclear. 191 Thus the BNST remains a site of interest as a target for central OT actions facilitating the reflex, but it would appear the output of the OT-excited BNST neurons is probably polysynaptic to OT milk ejection neurons, and the overall importance of this structure to the reflex per se is unclear.…”

Section: Forebrain Regions Modulating Milk Ejection Activitymentioning

confidence: 99%

Central Nervous System Control of Oxytocin Secretion during Lactation

Armstrong

2015

Knobil and Neill's Physiology of Reproduction

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“…Day 4 postpartum lesions of the dorsolateral BNST have little effect on maternal behavior , although the very early postpartum increase in OTR expression here suggests that prepartum lesions of this area might effectively disrupt the onset of maternal behavior. Alternatively, changes in OTR expression on the day of parturition might be more closely related to the postpartum estrus or the onset of lactation rather than maternal behavior, as maternally sensitized females do not have increased OTR binding in either the BNST or VMH (Insel, 1990), and some BNST cells are responsive to suckling and are involved in milk letdown (Lambert et al, 1993).…”

Section: Oxytocin Receptorsmentioning

confidence: 99%