2016
DOI: 10.1186/s12950-016-0140-5
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Electric stimulation of the vagus nerve reduced mouse neuroinflammation induced by lipopolysaccharide

Abstract: BackgroundNeuroinflammation (NI) is a key feature in the pathogenesis and progression of infectious and non-infectious neuropathologies, and its amelioration usually improves the patient outcome. Peripheral inflammation may promote NI through microglia and astrocytes activation, an increased expression of inflammatory mediators and vascular permeability that may lead to neurodegeneration. Several anti-inflammatory strategies have been proposed to control peripheral inflammation. Among them, electrical stimulat… Show more

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Cited by 87 publications
(64 citation statements)
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“…In our study pVNS improved microglial morphology after LPS injection, with more cells retaining ramified branches as found under homeostatic states. As anticipated, pVNS reduced microglial activation, including Iba-1 and CD68, at 24 h in a manner similar to other VNS approaches [13, 37, 38]. These effects on glia activation may result from the systemic anti-inflammatory effects of VNS leading to a reduction in the overall neuroinflammatory burden, including Toll-like receptors signaling, rather than through a direct action as mediated through α7 nAChRs on microglia cells.…”
Section: Discussionsupporting
confidence: 71%
See 1 more Smart Citation
“…In our study pVNS improved microglial morphology after LPS injection, with more cells retaining ramified branches as found under homeostatic states. As anticipated, pVNS reduced microglial activation, including Iba-1 and CD68, at 24 h in a manner similar to other VNS approaches [13, 37, 38]. These effects on glia activation may result from the systemic anti-inflammatory effects of VNS leading to a reduction in the overall neuroinflammatory burden, including Toll-like receptors signaling, rather than through a direct action as mediated through α7 nAChRs on microglia cells.…”
Section: Discussionsupporting
confidence: 71%
“…VNS commonly requires surgical implantation of electrodes around the cervical vagus and has been reported both to attenuate systemic inflammation after LPS treatment [12] and reduce neuroinflammation in rodent models [13]. Although this approach provides direct nerve stimulation, the procedure is invasive and not amenable to acute or ambulatory settings.…”
Section: Introductionmentioning
confidence: 99%
“…“Electroceuticals” have been considered a promising future for treating a number of diseases including central inflammatory and neurological disorders (Famm et al, 2013). Recent studies showed that electrical stimulation of peripheral nerves (including vagus) or direct brain stimulation, induces protective effects in ischemic stroke, traumatic brain injury, as well as in experimental cerebral ischemia and reperfusion (Jiang et al, 2014; Meneses et al, 2016; Notturno et al, 2014; Schweighöfer et al, 2016). …”
Section: Discussionmentioning
confidence: 99%
“…Additionally, TNF‐α inhibition has been found to protect the BBB, reducing inflammation and cerebral edema . Two novel strategies to control brain inflammation, described in detail below, have been recently studied in our research group …”
Section: Strategies To Control Brain Inflammation During Sepsismentioning
confidence: 99%
“…Considering the possible benefits of a tight control of NI, we propose two approaches for its modulation during septic processes, aiming to improve the disease outcome. One of them involves administering low doses of an anti‐inflammatory drug directly to the CNS by the intranasal route; the other one employs electrical stimulation of the vagus nerve …”
Section: Anti‐neuroinflammatory Treatment In Sepsismentioning
confidence: 99%