2011
DOI: 10.1002/adma.201102090
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Electric‐Field‐Assisted Protein Transport, Capture, and Interferometric Sensing in Carbonized Porous Silicon Films

Abstract: A carbonized porous silicon Fabry–Perot film acts as an electrically addressable, label‐free optical biosensor that allows simultaneous separation, capture, and detection of charged proteins within a volume of 5 nL. Electroadsorption of protein within the 40 nm diameter pores is induced by an applied bias and the process is monitored in real‐time by optical interferometry.

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Cited by 25 publications
(26 citation statements)
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“…Porous silicon is a versatile material with uses in a broad range of technological fields including energetic materials [1][2][3][4], and a variety of sensing applications [5][6][7]. Several of its material characteristics, including high surface area, energy density, and MEMS compatibility make PS a particularly interesting candidate for the field of energetic materials.…”
Section: Introductionmentioning
confidence: 99%
“…Porous silicon is a versatile material with uses in a broad range of technological fields including energetic materials [1][2][3][4], and a variety of sensing applications [5][6][7]. Several of its material characteristics, including high surface area, energy density, and MEMS compatibility make PS a particularly interesting candidate for the field of energetic materials.…”
Section: Introductionmentioning
confidence: 99%
“…[33][34][35] In addition, the surface chemistry of PSi can be modified easily. [36][37][38] Among the different surface chemistries, thermally carbonized PSi displays a highly increased electrical conductivity, 39,40 which enables, along with the possibility of fabricating nano-and microparticles, the preparation of PSi-based solution-processable inks needed for making printable devices. In the current study, the feasibility of PSi particles for printed humidity sensor production is explored.…”
mentioning
confidence: 99%
“…Importantly, white light reflectance-based interferometry constitutes a robust optical transduction method in PSi systems, making them powerful label-free detectors for various biomolecules. [15][16][17] However, PSi biosensors suffer from practical limitations related to the single-mode optical sensing mechanism, which mainly include poor sensitivity (typical limit of detection in the micromolar range 14,18 ) and lack of selectivity (for example, distinguishing between different analytes and the detection of more than one target analyte at once 14,19 ). Extensive research efforts have been directed toward enhancing the sensing properties of PSi-based systems.…”
Section: Introductionmentioning
confidence: 99%