Electric Field Analysis of Breast Tumor Cells

Sree, V. Gowri; Udayakumar, K.; Sundararajan, Raji

doi:10.4061/2011/235926

Cited by 14 publications

(4 citation statements)

References 11 publications

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“…It was reported that the electric field is decreased if the same protocol is used for tumors, deep seated with a human breast [14]. The tumor tissue had lower electric field strength compared to normal cells [15]. The capacitance or conductance of breast cancer malignancy is 50 times higher than that of normal tissues or benign lesions [15].…”

Section: Results and Analysismentioning

confidence: 97%

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Electric field distribution of malignant breast tissue under needle electrode configuration

Varadarajan

Velvizhi

Sundararajan

2012

2012 Annual Report Conference on Electrical Insulation and Dielectric Phenomena

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Breast cancer is the second leading disease causing death in women. The most recent data tells that breast cancer accounts for 28% to 38% of all cancers in women in big cities like Mumbai, Delhi, Chennai, etc. in India and it is also becoming an issue worldwide with 400,000+ deaths an year. This indicates that the current standard of cure is not adequate and we need additional/alternate therapies. Electrochemotherapy, which is the process by which external electrical pulses are applied to facilitate the transport of chemo drugs in to cells, is gaining momentum as an alternative treatment for chemorefractory and inoperable cancers. This paper deals with the electric field distribution study of breast tissue with ductal carcinoma model using MAXWELL 3D Simulator. The results indicate that the electric field distribution is in general homogeneous and the malignant tissue has different electric field intensity compared to the normal tissue for a given condition, depending upon with or without fat and skin.

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Section: Results and Analysismentioning

confidence: 97%

“…The tumor tissue had lower electric field strength compared to normal cells [15]. The capacitance or conductance of breast cancer malignancy is 50 times higher than that of normal tissues or benign lesions [15].…”

Section: Results and Analysismentioning

confidence: 99%

Electric field distribution of malignant breast tissue under needle electrode configuration

Varadarajan

Velvizhi

Sundararajan

2012

2012 Annual Report Conference on Electrical Insulation and Dielectric Phenomena

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“…The efficiency of this approach depends on effective permeabilization of target cells due to exposure of adequate electric field distribution. As per the this technique, a potential difference is induced across the membrane because of the external electric field and thereby establishing a transmembrane voltage (TMV) [6,7]. H. P. Schwan and co-workers came up with the canonical theory of TMV [6].…”

Section: Introductionmentioning

confidence: 98%

Anti-proliferation control of breast cancer cells using electric pulses

Sree

Muthuraman

Sundararajan

2015

2015 IEEE 11th International Conference on the Properties and Applications of Dielectric Materials (ICPADM)

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Pulsed Electric Field (PEF) involves application of pulses of strong electric field ranging from 1.2 kV/cm to 300 kV/cm or more with ultra-short time durations of up to 10 ns, for enhanced delivery of typically impermeable molecules, such as chemo drugs, genes and vaccines in the medical field. The objective of our work is to observe the efficacy of the potent and unique anticancer drug, cisplatin along with PEF on the anti-proliferation of MCF-7, human cancer cells. The cells were treated with cisplatin of different concentrations alongside PEF of 1008 V and 1280 V amplitude and a pulse width of 20 microseconds (µs). Our results show significant reduction in cell viability when cells are treated with the combination of PEF and cisplatin compared to drug alone or pulses alone. The highest percentage decrease of viable cancer cells was found to be 34 for 1280 V at a low drug concentration of 31.2 µg/ml.

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“…The various parameters which influence the process of electroporation are electric potential (field intensity), pulse width, number of pulses, types of chemo drug, and size and geometry of the tumor [5][6][7]. In addition, the efficiency of electroporation also depends on the type, size and shape of electrodes.…”

Section: Introductionmentioning

confidence: 99%

Influence of Electrodes on Electric Field Distribution for Effective Electrochemotherapy

Sundararajan¹

2016

JCPCR

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Electroporation is the application of electrical pulses for enhanced drug delivery. When used for delivering chemo drugs, it is called electrochemotherapy (ECT). For inoperable and chemo-and radio-resistant tumors, we need an alternative technique and ECT is a viable option as evidenced by the treatment of thousands of patients, effectively. The efficiency of the ECT depends on the voltage (electric field) magnitude, pulse duration, number of pulses, the drug molecule to be delivered and the electrode geometry and size. It is of practical interest to study the effect of electrode material on the efficacy of the therapy. Towards this, in this research, we investigated the influence of electric field distribution due to different electrode materials. For this purpose, both platinum and surgical steel needle array electrodes were used. Surgical steel is the most commonly used material for electro chemotherapy applications. These needle electrodes are of both hexagonal and pentagonal configurations with a central electrode in each.ANSYS, the industry standard software that uses finite element method is used to study the electric field distribution, of both healthy tissue and tumor tissue using these two electrode configurations and the two different materials. Both unipolar and bipolar voltages were studied.The results indicate that the electric field distribution, both in magnitude and pattern is similar for both electrodes, for both configurations and materials, which is desired from the clinical aspect. The electric field intensities for the hexagonal and pentagonal needle electrodes were 1280V/cm and 1180V/cm respectively in the case of tumor tissue (correlating well with the desired level of 1200V/cm). They were 835V/cm and 843V/cm for these electrodes in the case of healthy tissues. The values were same in the case of bipotential voltages too. Submit Manuscript

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Electric Field Analysis of Breast Tumor Cells

Cited by 14 publications

References 11 publications

Electric field distribution of malignant breast tissue under needle electrode configuration

Electric field distribution of malignant breast tissue under needle electrode configuration

Anti-proliferation control of breast cancer cells using electric pulses

Influence of Electrodes on Electric Field Distribution for Effective Electrochemotherapy

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