Electret Induced Callus Formation in the Rat

Inoue, Shoichi; Ohashi, Toshiro; Yasuda, Iwao; Fukada, E.

doi:10.1097/00003086-197705000-00008

Cited by 2 publications

(2 citation statements)

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“…Consequently, the present method was perfectly free from edematous damage by the electric current. The electrically polarized HAp ceramics continuously maintained electrostatic forces for more than 60 days while the polytetrafluoroethylene (Teflon®)37, 38 electret polymer for electric stimulation became discharged and was ineffective within 7 days. Although piezoelectric polymers, such as poly‐γ‐methyl‐ L ‐glutamate (PMLG),38, 39 were delivering on the order of 1 pAcm −2 current, the polymers were bio‐incompatible and unsuitable for the scaffold of osteoblastic cells.…”

Section: Discussionmentioning

confidence: 99%

Enhanced osteobonding by negative surface charges of electrically polarized hydroxyapatite

Kobayashi¹,

Nakamura²,

Yamashita³

2001

J. Biomed. Mater. Res.

224

134

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Negative surface charges of electrically polarized hydroxyapatite ceramics have been proven to enhance osteobonding in canine bone tissues. Even in a wide gap of 0.2 mm between hydroxyapatite and bone, the negatively charged hydroxyapatite conducted formation of unidirectionally oriented bone layer into direct contact with the hydroxyapatite surface 7 days after implantation. By day 14, the gap was filled with maturing bones linked to each other while conventional hydroxyapatite required at least 28 days for direct bone-to-bone contact. The electrostatic force was deduced to have affected both the activation of bone formation by myeloid cells and the orientation of the bone domain on negatively charged surfaces.

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Section: Discussionmentioning

confidence: 99%

Enhanced osteobonding by negative surface charges of electrically polarized hydroxyapatite

Kobayashi¹,

Nakamura²,

Yamashita³

2001

J. Biomed. Mater. Res.

224

134

View full text Add to dashboard Cite

show abstract

“…[21][22][23] A more permanent electrically polarized material, such as Teflon, showed accelerated osteointegration and bone first formed at the negative pole, growing toward the positive pole. 12,24 Furthermore, electrically polarized bioactive HAp showed improved osteointegration at the negatively charged surface pole. [25][26][27] Since electrical polarization showed improved bone formation at negatively charged surfaces of different biomaterials, functionalizing polymer surface with fixed negative electrical charge could in theory enhance any biomaterial's osteoconductive and osteoinductive properties.…”

Section: Introductionmentioning

confidence: 99%

Effect of Biomaterial Electrical Charge on Bone Morphogenetic Protein-2-Induced In Vivo Bone Formation

Olthof

Kempen

Liu

et al. 2019

Tissue Engineering Part A

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Biomaterials that act as both protein delivery vehicle and scaffold can improve the safety and efficacy of bone morphogenetic protein-2 (BMP-2) for clinical applications. However, the optimal scaffold characteristics are not known. The osteoinductive and osteoconductive capacity of a fixed electrically charged surface is thus far unexplored. Therefore, in this study, we aim to investigate the effect of different electrical states on BMP-2induced bone formation in oligo[(polyethylene glycol) fumarate] (OPF) hydrogels. Neutral, negatively, or positively charged scaffolds were fabricated using unmodified OPF (neutral charge), sodium methacrylate crosslinked OPF (negative charge), or [2-(methacryloyloxy) ethyl] trimethylammonium chloride crosslinked OPF (positive charge), respectively. To allow investigation of surface charge for different BMP-2 release rates, three BMP-2 release profiles were generated by protein encapsulation into poly(lactic-co-glycolic acid) microspheres and/or adsorption on the OPF composite. Release of radiolabeled 125 I-BMP-2 was analyzed in vitro and in vivo and bone formation was assessed after 9 weeks of subcutaneous implantation in rats. Negatively charged OPF generated significantly more bone formation compared with neutral and positively charged OPF. This effect was seen for all three loading methods and subsequent BMP-2 release profiles. Along with charge modifications, a more sustained release of BMP-2 improved overall bone formation in OPF composites. Overall, this study clearly shows that negative charge enhances bone formation compared with neutral and positive charge in OPF composites.

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Electret Induced Callus Formation in the Rat

Cited by 2 publications

References 0 publications

Enhanced osteobonding by negative surface charges of electrically polarized hydroxyapatite

Enhanced osteobonding by negative surface charges of electrically polarized hydroxyapatite

Effect of Biomaterial Electrical Charge on Bone Morphogenetic Protein-2-Induced In Vivo Bone Formation

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