Elective Total Gastrectomy for Cancer of the Stomach

Abstract

There has been no apparent improvement in overall salvage of patients with cancer of the stomach treated by elective extended total gastrectomy from 1950-1964 as compared with those treated by partial gastrectomy during the preceding 20-year period, 1931-1950 at Memorial Hospital in New York City. Criteria of resectability have been extended in recent years, and, therefore, the two series of patients cannot be considered strictly comparable. In the 94 patients subjected to elective total gastrectomy for cancer of the stomach, more than half (55 patients) had cancer in the proximal 1/3 of the stomach. The results obtained in this group by total gastrectomy are inferior to those obtained in the earlier series by partial gastrectomy. Patients with carcinoma of the mid 1/3 of the stomach showed essentially the same 5-year survival by elective total gastrectomy (34.8%) as by partial gastrectomy (33.5%), while those with carcinoma of the distal 1/3 of the stomach showed a greater 5-year survival by elective total gastrectomy (43.7%) than by partial gastrectomy (29.8%). However, of significance is the fact that the incidence of nodal metastasis was 3 times greater in the patients undergoing elective total gastrectomy than in those undergoing partial gastrectomy. Despite this unfavorable finding, 5-year survival in the patients undergoing elective total gastrectomy for carcinoma of the mid 1/3 or distal 1/3 of the stomach was equal to, or better than, that found in those undergoing partial gastrectomy for lesions similarly located. On the basis of this finding alone, we believe that elective total gastrectomy is a worthwhile endeavor and should be performed for operable carcinomas arising in the mid 1/3 or distal 1/3 of the stomach.

Factors influencing survival in 242 cases of primary gastric carcinoma

“…65% of which were treated with SGR, was comparable to that reported by other authors with more radical surgical procedures [6,8,11,12,15].…”

Surgical treatment and prognosis of gastric cancer in 2 613 patients

“…There is still controversy over the impact of the extent of resection for tumors located in the upper third of the stomach (including cardia and fundus) [21] . Some researchers [22][23][24][25] advocate the performance of PSG so as to possibly retain the stomach even partially, and proper digestive function. It also enables patients to avoid the late stage complications following TG.…”

Is palliative resection necessary for gastric carcinoma patients?

“…The literature reports 3-year survival rates of 7-12.6% [16,19]. Regardless of the number of metastatic sites, we had a 7.03% 5-year survival rate in patients with palliative resection.…”

“…Therefore, we do not consider old age to be a contraindication to surgery. Other reports have stated that palliative resections are not associated with an increased postoperative mortality rate [16][17][18], although Hartgrink et al [7] did not recommend palliative resection for patients more than 70 years of age. They reported that when morbidity, hospital stay, and mortality are considered, no benefit exists for patients over the age of 70 undergoing palliative resection.…”