Elective neck dissection versus observation in early stage oral squamous cell carcinoma: recurrence and survival

Kim, Dong Wook; Lee, Ba-Da; Lim, Jung Hwan; Park, Jung-Hyun; Nam, Woong; Kim, Hyung Jun; Cha, In‐Ho

doi:10.5125/jkaoms.2016.42.6.358

Cited by 4 publications

(7 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our meta‐analysis of eight studies revealed a similar DSS for patients in both groups (HR, 1.07; CI, 1.02–1.13; P = .31) (Fig. ).…”

Section: Meta‐analysis For End Versus Obsmentioning

confidence: 59%

“…Figure illustrates the study selection criteria and relevant reasons for exclusion. Finally, 15 studies including 3,158 patients were analyzed, comprising 1,726 patients undergoing END and 1,432 under OBS (Tables and ) …”

Section: Resultsmentioning

confidence: 99%

“…Our meta‐analyses of 9 studies and 14 studies revealed lower overall recurrence and lower neck recurrence, respectively, in patients undergoing END than in patients under OBS ([HR, 1.60; CI, 1.11–2.09; P = .03; Fig. S7] and [HR, 2.23; CI, 1.64–2.83; P = .0026; Fig.…”

Section: Meta‐analysis For End Versus Obsmentioning

confidence: 86%

See 2 more Smart Citations

Elective Neck Dissection Versus Observation in Early‐Stage (cT1/T2N0) Oral Squamous Cell Carcinoma

Liu

Chen

Bai

2019

Laryngoscope Investig Oto

View full text Add to dashboard Cite

Objectives Whether to perform elective neck dissection (END) or apply the observation (OBS) policy in patients with early‐stage oral squamous cell carcinoma (OSCC) without clinical evidence of cervical lymph node metastasis (cT1/T2N0) remains uncertain. The two most recent meta‐analyses include many studies published before the widespread availability of CT scanning in the 1990s. With the rapid advancement in imaging studies since 1990, the early clinical detection of cervical node metastasis has become more reliable without the need for END or pathological staging. Thus, we conducted a systematic review and meta‐analysis of studies comparing survival outcomes between END and OBS in patients with cT1/T2N0 OSCC. Methods We performed a systematic search of MEDLINE, PubMed, and Scopus for retrospective and prospective studies published between January 1, 1990, and January 1, 2018, comparing clinical outcomes between END and OBS in patients with cT1/T2N0 OSCC. Information on population characteristics, study design, overall survival (OS), disease‐specific survival (DSS), and disease‐free survival (DFS) was extracted and estimated. Effect measures for outcomes were hazard ratios (HRs) and 95% confidence intervals (CIs). Results Thirteen retrospective and two prospective randomized studies (3,158 patients) met the inclusion criteria. Compared to OBS, END failed to significantly improve OS (HR, 1.02; 95% CI, 0.95–1.09; P = .77; fixed‐effects model), DSS (HR, 1.07; CI, 1.02–1.13; P = .31; fixed‐effects model), and DFS (HR, 0.86; CI, 0.72–1.01; P = .12; random‐effects model). Conclusions Our findings indicate that in patients with cT1T2N0 OSCC, the OBS policy can yield markedly similar OS, DSS, and DFS to those resulting from END. Level of Evidence 2

show abstract

“…Our meta‐analysis of eight studies revealed a similar DSS for patients in both groups (HR, 1.07; CI, 1.02–1.13; P = .31) (Fig. ).…”

Section: Meta‐analysis For End Versus Obsmentioning

confidence: 59%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Elective Neck Dissection Versus Observation in Early‐Stage (cT1/T2N0) Oral Squamous Cell Carcinoma

Liu

Chen

Bai

2019

Laryngoscope Investig Oto

View full text Add to dashboard Cite

show abstract

“…This study found that these patients had similar survival outcomes as those treated with END. Currently, some studies still considered that cT2 patients should receive END because of the high occult metastases and poor survival outcomes ( 7 , 8 , 20 ). In our study, since patients treated with OBS could have a close follow-up and receive therapeutic neck dissection in time, we found similar survival rates in cT1 and cT2 patients between the OBS and END groups.…”

Section: Discussionmentioning

confidence: 99%

Neck observation versus elective neck dissection in management of clinical T1/2N0 oral squamous cell carcinoma: a retrospective study of 232 patients

Liu

Lao

Liang

et al. 2017

Chinese Journal of Cancer Research

View full text Add to dashboard Cite

ObjectiveThe management of early-stage (cT1/2N0) oral squamous cell carcinoma (OSCC) remains a controversial issue. The aim of this study was to compare the clinical outcomes of neck observation (OBS) and elective neck dissection (END) in treating patients with cT1/2N0 OSCC.MethodsA total of 232 patients with cT1/2N0 OSCC were included in this retrospective study. Of these patients, 181 were treated with END and 51 with OBS. The survival curves of 5-year overall survival (OS), disease-specific survival (DSS), and recurrence-free survival (RFS) rates were plotted using the Kaplan-Meier method for each group, and compared using the Log-rank test.ResultsThere was no significant difference in 5-year OS and DSS rates between END and OBS groups (OS: 89.0% vs. 88.2%, P=0.906; DSS: 92.3% vs. 92.2%, P=0.998). However, the END group had a higher 5-year RFS rate than the OBS group (90.1% vs. 76.5%, P=0.009). Patients with occult metastases in OBS group (7/51) had similar 5-year OS rate (57.1% vs. 64.1%, P=0.839) and DSS rate (71.4% vs. 74.4%, P=0.982) to those in END group (39/181). In the regional recurrence patients, the 5-year OS rate (57.1% vs. 11.1%, P=0.011) and DSS rate (71.4% vs. 22.2%, P=0.022) in OBS group (7/51) were higher than those in END group (9/181). ConclusionsThe results indicated that OBS policy could obtain the same 5-year OS and DSS as END. Under close follow-up, OBS policy may be an available treatment option for patients with clinical T1/2N0 OSCC.

show abstract

“…Following the development and piloting of the STROBE-M score checklist, we conducted a more formal evaluation of its inter-rater agreement. One reviewer (VL) selected 45 observational study publications (15 each from cross-sectional (23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37), cohort (38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48)(49)(50)(51)(52), and case-control study (53-67) from ìPubMed databaseî published in the time period of 1 st March 2016 to 31 st May 2016 with the filters of English language, human studies, and full text availability. Irrelevant publications (opinion or critique of previous studies, letters to editors, meta-analysis were excluded (Fig.…”

Section: Inter-rater Agreement Of Strobe-m Score Checklistmentioning

confidence: 99%

Development of a Quantitative Scoring Method for Strobe Checklist

Limaye¹,

Limaye²,

Pitani³

et al. 2018

Acta Poloniae Pharmaceutica - Drug Research

View full text Add to dashboard Cite

Evidence-based medicine (EBM) has brought a substantial change in medical practice and clinical care approach (1-3). It has helped to focus on valid and reliable information to make sound decisions in the area of disease management. Although randomized controlled trials (RCTs) are considered as the reference standard and provide valuable evidence about the efficacy of new treatments, yet they do not answer all important questions about the specific treatment. Most of the knowledge in clinical practice comes from observational studies from which we can gain further experience to plan interventional studies in regards to efficacy, safety and tolerability of approved medicines (4). An observational study is defined as a study that provides estimates and examines associations of events in their natural settings without recourse to experimental intervention (5). It includes cohort studies (CO) ñ prospective and retrospective, crosssectional studies (CS), and case-control studies (CC) (6). Current evidence suggests that observational studies, such as those discussed earlier, both com

show abstract

Elective neck dissection versus observation in early stage oral squamous cell carcinoma: recurrence and survival

Cited by 4 publications

References 16 publications

Elective Neck Dissection Versus Observation in Early‐Stage (cT1/T2N0) Oral Squamous Cell Carcinoma

Elective Neck Dissection Versus Observation in Early‐Stage (cT1/T2N0) Oral Squamous Cell Carcinoma

Neck observation versus elective neck dissection in management of clinical T1/2N0 oral squamous cell carcinoma: a retrospective study of 232 patients

Development of a Quantitative Scoring Method for Strobe Checklist

Contact Info

Product

Resources

About