Elective caesarean-section versus vaginal delivery in prevention of vertical HIV-1 transmission: a randomised clinical trial

Parazzini, Fabio

doi:10.1016/s0140-6736(98)08084-2

Cited by 524 publications

(48 citation statements)

References 16 publications

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“…In a randomized trial, the European Mode of Delivery Collaborative demonstrated a 50% reduction of vertical transmission with the use of scheduled cesarean section [11]. This finding was confirmed by a large meta-analysis [12].…”

Section: Discussionmentioning

confidence: 90%

Postpartum Morbidity Associated With Advanced HIV Disease

Louis

Buhari

Allen

et al. 2006

Infectious Diseases in Obstetrics and Gynecology

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Objective. To investigate the postpartum morbidity and postpartum management of febrile morbidity associated with advanced HIV infection. Methods. A case control study of HIV infected women at a tertiary care center during January 2000–June 2005 was performed. Postpartum morbidity was defined as endometritis, blood transfusion, wound complication, readmission, infectious morbidity, or unexpected surgery. Results. Women in Group 1 had AIDS (N = 33), Group 2 were relatively immunocompetent HIV infected women (N = 115), and Group 3 were uninfected women (N = 152). Group 1 was more likely to have a postpartum morbidity (32.3 versus 19.3 and 13.2%, P = .03) and to have postpartum imaging 18.8 versus 7.9 and 2.6%, P = .002. After controlling for potential confounders, cesarean delivery (OR 6.2, 95% CI 2.1–505.5) but not advanced HIV disease was associated with an increased risk of postpartum morbidity. Conclusion. Cesarean delivery and not advanced HIV disease increases the risk of postpartum morbidity in women with AIDS.

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Section: Discussionmentioning

confidence: 90%

Postpartum Morbidity Associated With Advanced HIV Disease

Louis

Buhari

Allen

et al. 2006

Infectious Diseases in Obstetrics and Gynecology

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“…Multiple studies from prospective cohort [6] [7], international randomized trial [8], and meta-analysis of individual patient's data from 15 prospective cohort studies include more than 7800 mothers-child pairs [9], found that there was a The education level owned by patient majority is in 9 -12 old, both mother (51.11%) and husband (53.33%) This education level is needed when providing information and education counseling for people living with HIV/ AIDS. This is primarily related to the complex problems need to be faced, not only the medical problems but also social and economic problems.…”

Section: /11 Oalib Journalmentioning

confidence: 99%

Incidence and Fetal Outcomes of HIV/Aids Patients at Hasan Sadikin General Hospital

Rachmawati¹,

Mose²,

Sadikin³

2017

OALib

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“…This is likely due, in part, to the role of cesarean delivery in reducing the risk of mother-to-child transmission (MTCT) of HIV type 1. Research conducted in the 1990s demonstrated that cesarean delivery performed prior to the onset of labor and prior to the rupture of the amniotic membranes can substantially reduce the risk of MTCT of HIV [4,5]. As such, the American College of Obstetricians and Gynecologists and the US Public Health Service recommend that HIV-infected women with plasma viral loads higher than 1000 copies/ml be counseled on the benefits of cesarean delivery performed at 38 weeks gestation to prevent MTCT of HIV [6,7].…”

Section: Introductionmentioning

confidence: 99%

“…Several studies have demonstrated that HIV-infected women are at increased risk of perioperative morbidity from cesarean delivery compared with HIV-uninfected controls [9–16], and their risk for morbidity is higher with cesarean as compared with vaginal delivery [4,9,17–19]. Most of this increased risk for morbidity is related to infection (e.g., urinary tract infection, pneumonia, wound infection, septicemia), which is elevated for all women undergoing cesarean delivery [20], such that the risks are greatest for cesarean deliveries performed after onset of labor or ruptured membranes, intermediate with scheduled cesarean delivery, and lowest with vaginal delivery [21].…”

Section: Introductionmentioning

confidence: 99%

“…Although the studies upon which existing US guidelines were made demonstrate a clear benefit in reducing MTCT that outweighs potential risks of morbidity, most were conducted before the widespread use of HAART [21–23]. As maternal viral load is significantly associated with risk of MTCT [24–30], the additional benefit of scheduled cesarean delivery when full viral suppression has been achieved through the use of HAART has been questioned [31–33], and the US guidelines, as mentioned, do not recommend elective cesarean delivery in women with undetectable viral load [4,5]. …”

Section: Introductionmentioning

confidence: 99%

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Complications of cesarean deliveries among HIV-infected women in the United States

Kourtis

Ellington

Pazol

et al. 2014

Aids

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Objective To compare rates of complications associated with cesarean delivery in HIV-infected and HIV-uninfected women in the United States and to investigate trends in such complications across four study cycles spanning the implementation of HAART in the United States (1995–1996, 2000–2001, 2005–2006, 2010–2011). Design The Nationwide Inpatient Sample from the Healthcare Cost and Utilization Project is the largest all-payer hospital inpatient care database in the United States; when weighted to account for the complex sampling design, nationally representative estimates are derived. After restricting the study sample to women aged 15–49 years, our study sample consisted of approximately 1 090 000 cesarean delivery hospitalizations annually. Methods Complications associated with cesarean deliveries were categorized as infection, hemorrhage, or surgical trauma, based on groups of specific International Classification of Diseases 9th revision codes. Length of hospitalization, hospital charges, and in-hospital deaths were also examined. Results The rate of complications significantly decreased during the study periods for HIV-infected and HIV-uninfected women. However, rates of infectious complications and surgical trauma associated with cesarean deliveries remained higher among HIV-infected, compared with HIV-uninfected women in 2010–2011, as did prolonged hospital stay and in-hospital deaths. Length of hospitalization decreased over time for cesarean deliveries of HIV-infected women to a greater extent compared with HIV-uninfected women. Conclusion In the United States, rates of cesarean delivery complications decreased from 1995 to 2011. However, rates of infection, surgical trauma, hospital deaths, and prolonged hospitalization are still higher among HIV-infected women. Clinicians should remain alert to this persistently increased risk of cesarean delivery complications among HIV-infected women.

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Elective caesarean-section versus vaginal delivery in prevention of vertical HIV-1 transmission: a randomised clinical trial

Cited by 524 publications

References 16 publications

Postpartum Morbidity Associated With Advanced HIV Disease

Postpartum Morbidity Associated With Advanced HIV Disease

Incidence and Fetal Outcomes of HIV/Aids Patients at Hasan Sadikin General Hospital

Complications of cesarean deliveries among HIV-infected women in the United States

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