Elderly with proximal hip fracture present significantly lower levels of 25-hydroxyvitamin D

Abstract

ObjectiveTo compare serum 25-hydroxyvitamin D (25[OH]D) levels, a serum marker of vitamin D3, between patients with and without proximal hip fracture.MethodsThis was a case–control study in which serum samples of 25(OH)D were obtained from 110 proximal hip fracture inpatients and 231 control patients without fractures, all over 60 years of age. Levels of 25(OH)D lower than or equal to 20 ng/mL were considered deficient; from 21 ng/mL to 29 ng/mL, insufficient; and above 30 ng/mL, sufficient. Sex, age, and ethnicity were considered for association with the study groups and 25(OH)D levels.ResultsPatients with proximal hip fracture had significantly lower serum 25(OH)D levels (21.07 ng/mL) than controls (28.59 ng/mL; p = 0.000). Among patients with proximal hip fracture, 54.5% had deficient 25(OH)D levels, 27.2% had insufficient levels, and only 18.2% had sufficient levels. In the control group, 30.3% of patients had deficient 25(OH)D levels, 30.7% had insufficient levels, and 38.9% had sufficient levels. Female patients had decreased serum 25(OH)D levels both in the fracture group and in the control group (19.50 ng/mL vs. 26.94 ng/mL; p = 0.000) when compared with male patients with and without fracture (25.67 ng/mL vs. 33.74 ng/mL; p = 0.017). Regarding age, there was a significant association between 25(OH)D levels and risk of fracture only for the age groups 71–75 years and above 80 years.ConclusionPatients with proximal hip fracture had significantly decreased serum 25(OH)D levels when compared with the control group. Female patients had significantly lower serum 25(OH)D levels in both groups.

Seasonality of hip fracture and vitamin D deficiency persists in a sub‐tropical climate

“…25‐OHD deficiency was found to be common in patients with hip fractures in Singapore which is situated near the equator and classified as a tropical climate . This is also the case with Brazil, a country with a mostly tropical climate and Taiwan, a sub‐tropical country, where the hip fracture rate significantly increases during winter …”

“…Internal Medicine Journal 49 (2019) 1029-1032 © 2019 Royal Australasian College of Physicians fractures in Singapore which is situated near the equator and classified as a tropical climate. 10 This is also the case with Brazil, a country with a mostly tropical climate 11 and Taiwan, a sub-tropical country, where the hip fracture rate significantly increases during winter. 12 The Australian Health Survey 2011-2012 found overall high levels of vitamin D insufficiency in winter and spring regardless of the location in Australia and high prevalence of 25-OHD deficiency all year round which peaked in spring.…”

Avaliação do perfil laboratorial de idosos com fratura de fêmur proximal por mecanismo de baixa energia

“…Another evidence of this study was that patients who live in nursing homes have lower vitamin D levels at admission. In another controlled study, Guerra et al 14 evaluated 110 patients with hip fracture, 54.5% of whom presented vitamin D deficiency, and 18.2% with vitamin D insufficiency. The authors show that there was a statistically significant difference between the fracture and the control groups for patients older than 70 years, which did not occur in patients aged 60 to 65 years.…”

“…Outra evidência desse estudo foi que os pacientes que viviam em casas de repouso apresentaram níveis menores de Vitamina D em sua análise admissional. Em outra análise com grupo e controle, Guerra et al 14 avaliaram 110 pacientes com fratura de quadril, dentre os quais 54,5% apresentaram deficiência de vitamina D e 18,2% apresentaram níveis insuficientes. O autor mostra que houve diferença estatisticamente significativa entre o grupo fratura e o grupo controle, para os pacientes com idade superior a 70 anos, o que não ocorreu em pacientes com idade entre 60 e 65 anos.…”

Prevalência da deficiência de vitamina D em pacientes com fraturas ocasionadas por trauma de baixa energia

“…Guerra et al 15 reported a case control study comparing 110 elderly patients with fractures to 231 control patients without fractures. Among the fracture group, 54, 27.2 and 18.2% of the patients presented vitamin D deficiency, insufficiency and sufficiency, respectively, in addition to lower levels compared with the control group.…”