Elderly patients with rectal cancer have a higher risk of treatment-related complications and a poorer prognosis than younger patients: A population-based study

Shahir, M.A.; Lemmens, Valery; Poll‐Franse, Lonneke V. van de; Voogd, A.C.; Martijn, Hendrik; Janssen‐Heijnen, M.L.G.

doi:10.1016/j.ejca.2005.10.032

Cited by 117 publications

(67 citation statements)

References 30 publications

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“…However, there were no significant differences either in the overall rate of local complications (infection of the surgical wound, anastomotic fistulae or intra-abdominal abscesses) or when rates of such complications were analysed separately. These findings agree with those of other authors (6,20,21,(25)(26)(27)(28)(29).…”

Section: Discussionsupporting

confidence: 81%

Colorectal cancer in the elderly: characteristics and short term results

Arenal-Vera¹,

Tinoco-Carrasco²,

del-Villar-Negro

et al. 2011

Rev. esp. enferm. dig.

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Objective: to analyse the characteristics of colorectal cancer in elderly patients and to assess the outcomes of treatment.Materials and methods: the study included 1924 patients diagnosed with colorectal cancer during a 22 year period . We analysed patient clinical and demographic characteristics as well as their treatment and its outcome.Results: there was an increase in emergency surgery with age, increasing from 13% among patients under 80 years of age to 47% in those over 90 years of age (p = 0.0001). On the other hand, the overall percentage of patients who underwent surgical treatment decreased from 96% in patients younger than 80 years of age, to 85% and 59% in octogenarians and nonagenarians, respectively (p = 0.0001), and there was a similar pattern in the rates of curative surgery among patients who underwent surgery. The overall mortality of patients who underwent surgery was 8% (141 out of 1,769), increasing from 4% in patients younger than 70 years of age to 25% in those over 90 (p = 0.0001). Multivariate analysis showed that the factors associated with mortality were the emergency nature of the surgery (p = 0.001), the ASA grade (p = 0.0001), and the presence of systemic complications (p = 0.0001), the weight of age decreasing significantly with respect to the univariate analysis (p = 0.013).Conclusions: there is an increase in the rate of complicated forms of colorectal cancer with increasing age of patients. In addition, there is a dramatic decrease in the rate of curative tumour resection with increasing age. Intraoperative mortality for colorectal cancer in octogenarians and nonagenarians is more closely related to the nature and intent of the surgery (elective or emergency; palliative or curative), the perioperative risk (ASA grade), and severe systemic complications, than to age.

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Section: Discussionsupporting

confidence: 81%

Colorectal cancer in the elderly: characteristics and short term results

Arenal-Vera¹,

Tinoco-Carrasco²,

del-Villar-Negro

et al. 2011

Rev. esp. enferm. dig.

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“…A study from the south of the Netherlands demonstrated a higher risk of developing treatment-related complications for older patients and patients with co-morbidity leading to a worse survival. [37] Another Dutch study revealed that elderly patients have more complications leading to higher mortality. Furthermore, complications with a similar occurrence rate in younger as well as elderly patients were associated with a higher mortality in the elderly.…”

Section: Preoperative Mortalitymentioning

confidence: 99%

Variation in treatment and outcome of patients with rectal cancer by region, hospital type and volume in the Netherlands

Elferink

Krijnen

Wouters

et al. 2010

European Journal of Surgical Oncology (EJSO)

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“…6 The consequences of these effects on HRQL and health care utilisation among elderly long-term cancer survivors have rarely been studied separately from results of younger cancer survivors and additionally, elderly patients are often excluded from clinical trials. However, the impact of cancer and its treatment can be different for older compared to younger patients due to a number of reasons including the higher prevalence of comorbid diseases, 7 a higher risk of treatment-related complications 8 and the fact that older patients often receive different therapies 7,9,10 compared to younger patients.…”

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confidence: 99%