Elderly men with a history of distal radius fracture have significantly lower calcaneal bone density and free androgen index than age-matched controls

Risto, Olof; Hammar, Erik; Hammar, Karl; Fredrikson, Mats; Hammar, Mats; Wahlström, Ola

doi:10.3109/13685538.2011.593659

Cited by 14 publications

(11 citation statements)

References 23 publications

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“…As in previous studies, BMD was also significantly lower at other sites, such as the hip and spine or heel compared with age-and gender-matched control subjects [8,9,23,24]. The significantly lower areal BMD persisted after adjustment for confounders.…”

Section: Discussionsupporting

confidence: 81%

“…A larger study may identify further important factors in the pathogenesis of these fractures in men. However, the study was adequately powered to detect the observed differences in BMD and included more participants than other published comparative studies [23,24]. It is also a case-control design, which introduces potential recall bias from participants.…”

Section: Discussionmentioning

confidence: 99%

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Does regional loss of bone density explain low trauma distal forearm fractures in men (the Mr F study)?

et al. 2017

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Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Does regional loss of bone density explain low trauma distal forearm fractures in men (the Mr F study)?

et al. 2017

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“…The main finding is that younger men, aged 20 to 50, seem to have an altered hormone profile with elevated LH and reduced level of cFT when compared to population-based age-matched controls. Our results are in line with finding among men in their seventies (21) . Although in a smaller study (n=39) and men with high-energy fractures excluded, they found 16% lower bioavailable testosterone in the fracture group compared to controls; in our young cohort cFT was 10% lower in fracture cases.…”

Section: Discussionsupporting

confidence: 93%

High Luteinizing Hormone and Lower Levels of Sex Hormones in Younger Men With Distal Radius Fracture

et al. 2020

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This study investigates the sex steroid hormone profile in younger men with distal radius fracture (DRF) in order to elucidate if this could explain the low bone density and osteoporosis previously observed. In a case-control study 73 men with DRF (mean age 38±9; range 20-51) was compared to 194 age-matched, population controls. Performed assays: total testosterone (TT), calculated free testosterone (cFT), luteinizing hormone (LH), follicle stimulating hormone (FSH), sex hormone binding globulin (SHBG), and total estradiol (E2). BMD hip and spine were measured. Fracture cases had lower cFT (298 vs 329 pmol/l; p=0.008) but not TT, compared to controls. FSH and SHBG were not statistically different. LH was almost 30% higher (5.7 vs 4.5 IU/l; p<0.001) and a lower E2 was observed (80.0 vs 87.1, p=0.098). Men with DRF had lower E2/SHBG ratio compared to controls (2.3 vs 2.9, p=0.013). A higher proportion of the fracture group had low TT (<10.5 nmol/L) 21% vs 11%, p=0.052, low cFT (<220 pmol/L) 18% vs 8%, p=0.017 and low E2 (<73 pmol/l) 48% vs 35%, p=0.044). Odds ratio for fracture when having low cFT was 2.3 (95% CI 1.02-5.49, p=0.044) and with low E2 1.7 (95% CI 0.96-2.96). In this study in young men with distal radius fracture exploring sex hormone levels, we find that sex hormone profiles may be disturbed with lower E2/SHBG ratio, lower cFT and higher luteinizing hormone. Estrogen is a strong determinant of bone mass also in men; hence, low levels of estradiol may be contributing to the observed lower BMD and these differences may be relevant to fracture risk.

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“…Among the factors affecting bone healing, local and systemic factors such as the degree and extent of injury, cardiovascular disorders, age, gender, chronic diseases, nutritional status, stimulants and drugs used should be mentioned. 3 – 5 For example, in the study of Jeffcoach et al, complications in the healing of long bone fractures occurred two to three times more frequently among smokers and patients taking NSAIDs than in the control group. 6 …”

Section: Bone Response To Traumamentioning

confidence: 99%

Positives and negatives of nonsteroidal anti-inflammatory drugs in bone healing: the effects of these drugs on bone repair

Lisowska

Kosson

Domaracka

2018

DDDT

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Tissue damage following injury triggers the processes of coagulation, inflammation and healing. In tissues surrounding the bone, the result of the healing process is a scar, while bone tissue has a unique ability to achieve shape, strength and pre-injury function. Bone healing is a process of regeneration rather than classic recovery. The result of this process is the formation of new, healthy bone tissue instead of a scar. Many factors can inhibit or impair the bone healing process, and their influence is critical during the stages of inflammation and angiogenesis and finally on the clinical outcome. Nonsteroidal anti-inflammatory drugs (NSAIDs) play an essential role associated with their analgesic potency and anti-inflammatory effects. NSAIDs are also the most often used drugs in patients who require pain control and inflammation reduction due to musculoskeletal diseases or injures. Although their analgesic effect is well documented, NSAIDs also interfere with bone healing; therefore, the relative benefits and disadvantages connected with their administration should be taken into consideration. Despite the negative effect, NSAIDs have beneficial properties, but their clinical benefits in relation to dose and time of use are still unclear. Therefore, in this review, we focus on bone healing with relation to the impact of NSAIDs.

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Elderly men with a history of distal radius fracture have significantly lower calcaneal bone density and free androgen index than age-matched controls

Abstract: Abstract:Background: Age related bone loss is widely accepted as related to decreased serum-levels

Cited by 14 publications

References 23 publications

Does regional loss of bone density explain low trauma distal forearm fractures in men (the Mr F study)?

Does regional loss of bone density explain low trauma distal forearm fractures in men (the Mr F study)?

High Luteinizing Hormone and Lower Levels of Sex Hormones in Younger Men With Distal Radius Fracture

Positives and negatives of nonsteroidal anti-inflammatory drugs in bone healing: the effects of these drugs on bone repair

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