Elateriospermum tapos Yoghurt as a Therapeutic Intervention for Obesity-Associated Cognitive Impairments and Anxiety-like Behaviour in a High Fat Diet Maternal Obese Rat Model

Naomi, Ruth; Teoh, Soo Huat; Rusli, Rusydatul Nabila Mahmad; Embong, Hashim; Bahari, Hasnah; Kumar, Jaya

doi:10.3390/nu15102312

Cited by 2 publications

(1 citation statement)

References 55 publications

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“…The preliminary study has identified that there are 64 bioactive compounds in E. tapos yogurt (Supplementary Table S1) [13,14]. These are the three selected compounds Scropolioside A, Flazin, and Medicagol which have been identified as potential bioactive compounds that fulfill the necessary criteria for drug screening (ADME), as shown in Table 2.…”

Section: Selection Of Potential Bioactive Compoundsmentioning

confidence: 99%

Analyzing Active Compounds in Elateriospermum tapos Yogurt for Maternal Obesity: A Network Pharmacology and Molecular Docking Study

Naomi,

Teoh,

Embong

et al. 2023

Foods

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Maternal obesity, characterized by an elevated body mass index (BMI) during pregnancy, is known to have adverse effects on the offspring. However, a recent study suggests that Elateriospermum tapos (E. tapos) yogurt may hold potential in mitigating excessive weight retention post-pregnancy. Thus, this study aims to employ network pharmacology to explore the pharmacological effects of the bioactive compounds present in E. tapos yogurt against maternal obesity. Initially, a screening process is conducted to identify the bioactive compounds in E. tapos yogurt, followed by the prediction of potential gene targets for these compounds using Swiss Target Prediction and the SuperPred databases. Maternal obesity-associated genes are sourced from the OMIM, DisGeNet, and GeneCards databases. The interaction between the identified compounds and maternal obesity genes is established via protein–protein interaction analysis, gene ontology examination, and KEGG pathway analysis. To validate the results, molecular docking studies are conducted using AutoDock Tools software. The findings reveal that out of the 64 compounds analyzed, three meet the screening criteria, resulting in a total of 380 potential gene targets. Among these targets, 240 are shared with maternal obesity-related genes. Further analysis demonstrates the favorable affinity of these active compounds with key targets, linking them to biological processes involving protein phosphorylation, inflammation, as well as the pathways related to lipid metabolism, atherosclerosis, and the other signaling pathways. In conclusion, this study provides valuable insights into the potential pharmacological effects of the bioactive compounds found in E. tapos yogurt against maternal obesity. These findings open avenues for further exploration and potential therapeutic interventions targeting maternal obesity.

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Section: Selection Of Potential Bioactive Compoundsmentioning

confidence: 99%