Elastoviscous hyaluronan in the synovium in health and disease

Balazs, Endre A.; Weiss, Charles

doi:10.1007/978-3-0348-8133-3_19

The Many Faces of Osteoarthritis 2002

DOI: 10.1007/978-3-0348-8133-3_19

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Elastoviscous hyaluronan in the synovium in health and disease

Endre A. Balazs

Charles Weiss

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Cited by 2 publications

References 38 publications

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Therapeutic use of hyaluronan

Balazs

2009

Struct Chem

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Hyaluronan used today as a therapeutic agent in human and animal medicine must be in a highly purified form, free of immunologically active protein molecules, from endotoxin and from inflammatory molecules originating from the tissues or bacterial cultures-the source of hyaluronan. All hyaluronans, whether in liquid or in covalently crosslinked gel form, must have certain elastoviscous properties to be usable for current therapeutic applications. Elastoviscous properties are especially important in the ophthalmic viscosurgical use. The metabolism of hyaluronan is very fast in most tissues, except in the vitreus. The ability of injected hyaluronan with a short half-life time in the joint to accomplish long-lasting analgesia represents a challenge for the design of the various products. The history of the therapeutic use of hyaluronan and its present status is described, with emphasis on its use in ophthalmic surgery and for a long-lasting analgesia in arthritic joints in humans and animals. The use of hyaluronan gels is described in viscoaugmentation as injected into the dermal layer of the skin. Hyaluronan gels were also used as viscosupplements injected into sphincter muscles to improve their function in aging or disease. The use of hyaluronan and its gel for drug delivery was suggested several decades ago, and is also mentioned.

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Therapeutic use of hyaluronan

Balazs

2009

Struct Chem

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Non-avian-derived hyaluronan for the treatment of osteoarthritis of the knee

Altman

2010

Expert Review of Clinical Immunology

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Osteoarthritis is among the leading causes of pain and reduced function in the USA, and its prevalence is increasing as the 'baby boom' generation ages. Present-day therapy is directed at the relief of pain, but the treatment armamentarium for moderate-to-severe osteoarthritis has been incomplete. Most existing treatments do not provide long-lasting effective pain relief and most also carry the risk of potentially distressing and/or dangerous systemic adverse effects. Intra-articular hyaluronan injections have significantly reduced pain for a majority of patients with osteoarthritis of the knee. Although the exact mechanism of action is not known, this treatment replaces lost endogenous hyaluronan and has direct actions on nerve endings, synovial cells and chondrocytes. This article discusses the rationale behind the development of intra-articular hyaluronan injections and describes one formulation that was the first highly purified result of a well-established extraction technique and a non-animal-derived exogenous origin.

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Elastoviscous hyaluronan in the synovium in health and disease

Cited by 2 publications

References 38 publications

Therapeutic use of hyaluronan

Therapeutic use of hyaluronan

Non-avian-derived hyaluronan for the treatment of osteoarthritis of the knee

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