Elastosis Perforans Serpignosa: Treatment with Liquid Nitrogen Cryotherapy and Review of the Literature

Humphrey, Shannon; Hemmati, Iman; Randhawa, Roop; Crawford, Richard; Hong, Chih-ho

doi:10.2310/7750.2009.08064

Cited by 12 publications

(5 citation statements)

References 14 publications

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“…Therefore, a cotton swab should be applied to the lesion for approximately 10 s for each round of clinical treatment. This superficial LNC technique is not only effective for LSC but also safer [27], and all 12 studies included in this meta-analysis used this approach.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and Safety of Liquid Nitrogen Cryotherapy for Lichen Simplex Chronicus: A Meta-Analysis

Zhong¹,

Wang²,

Li³

et al. 2021

Dermatology

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Background: Lichen simplex chronicus (LSC) is characterized by localized lichenification and intense itching. It has been reported that the added use of liquid nitrogen cryotherapy (LNC) for LSC has significant efficacy and notable safety. Therefore, we conducted a meta-analysis based on existing randomized controlled trials (RCTs). Method: We searched RCTs on LNC for LSC published up to August 2020 using various databases, including PubMed, EMBASE, Web of Science, Cochrane Central Register of Controlled Trials, China Network Knowledge Infrastructure (CNKI), Chinese Biomedicine (CBM), Chinese Scientific Journals Database (VIP), and WanFang Database. Other studies were manually identified using the references cited in reviews. We applied fixed- or random-effects models, and all analyses were performed using Review Manager 5.4 software. Results: Twelve RCTs involving 1,066 participants provided eligible data for the meta-analysis. Based on the clinical effective rate, LNC treatment of LSC (risk ratio, RR 1.25, p = 0.005, I2 = 82%) was superior to controls. Subgroup analysis showed that the use of LNC alone (RR 1.04, I2 = 95%, p > 0.05) is not more effective than other therapies in the treatment of LSC, but the addition of LNC to the existing treatment increases the total clinical efficacy. Furthermore, the combined effect of LNC and topical medication (RR 1.39, I2 = 0%, p < 0.0001) was better than that of LNC and oral medication (RR 1.30, I2 = 0%, p < 0.00001). Greater frequency of LNC treatment did not improve the efficacy (thrice a week: RR 1.39 [1.21, 1.60]; twice a week: RR 1.27; once every 2 weeks: RR 1.32). Data from 6 RCTs with 508 participants showed no significant difference in AEs (p = 0.31) associated with added LNC treatment. Conclusion: The addition of LNC (applying a cotton swab soaked with liquid nitrogen to wipe the lesion for approximately 10 s each time) to topical ointments, is effective and safe in the treatment of LSC. Increasing the treatment frequency of LNC did not necessarily improve the efficacy.

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Section: Discussionmentioning

confidence: 99%

Efficacy and Safety of Liquid Nitrogen Cryotherapy for Lichen Simplex Chronicus: A Meta-Analysis

Zhong¹,

Wang²,

Li³

et al. 2021

Dermatology

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“…The location on the body does not vary depending upon the particular disease or medication that it has caused. The patients are often young adults and the condition is seen more often in men [3].…”

Section: Case Discussionmentioning

confidence: 99%

“…The second type is related to systemic diseases such as cutis laxa, osteogenesis imperfecta, pseudoxanthoma elasticum, EDS, Marfan syndrome, and Down syndrome. The third type is drug induced by medication such as D-penicillamine [3][4][5].…”

Section: Case Discussionmentioning

confidence: 99%

Elastosis perforans serpiginosa related to vascular Ehlers-Danlos syndrome

Pallesen

Lindahl²,

Bygum³

2019

Dermatology Online Journal

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“…The management of EPS is challenging because many treatments have been reported, with variable efficacy. Reported effective treatments include cryotherapy (3), isotretinoin (4), imiquimod (5), and topical 0.1% tazarotene gel (6). Tazarotene has strong antiproliferative effects through the expression of tazarotene‐induced genes 1–3 (7) and the downregulation of keratins 6, 10, and 16.…”

Section: Discussionmentioning

confidence: 99%

An Erythematous Papular Lesion on the Neck of a Young Boy

Wilkinson¹,

Rahimi²,

Hohle³

et al. 2012

Pediatric Dermatology

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Elastosis Perforans Serpignosa: Treatment with Liquid Nitrogen Cryotherapy and Review of the Literature

Abstract: We report a case of EPS treated successfully with liquid nitrogen cryotherapy. Liquid nitrogen cryotherapy is well tolerated, with few side effects, and can be considered in the management of EPS.

Cited by 12 publications

References 14 publications

Efficacy and Safety of Liquid Nitrogen Cryotherapy for Lichen Simplex Chronicus: A Meta-Analysis

Efficacy and Safety of Liquid Nitrogen Cryotherapy for Lichen Simplex Chronicus: A Meta-Analysis

Elastosis perforans serpiginosa related to vascular Ehlers-Danlos syndrome

An Erythematous Papular Lesion on the Neck of a Young Boy

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