Elastosis Perforans Serpiginosa in a Patient With Renal Disease

Schamroth, J. M.

doi:10.1001/archderm.1986.01660130086032

Cited by 25 publications

(9 citation statements)

References 8 publications

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“…In the primary perforating disorders, an interaction between elastin and its receptor on keratinocytes in elastosis perforans serpingiosa 39 and an overexpression of TGF‐β 3 in reactive perforating collagenosis 40 have been described. For the acquired perforating dermatoses, several pathomechanisms have been proposed and include a possible pathogenetic role for fibronectin, 41,42 microtrauma associated with chronic pruritis and scratching, 43–45 abnormal vitamin A or vitamin D 46 metabolism, hypoxic skin conditions 47 and diabetes‐related microangiopathy 45 …”

Section: Discussionmentioning

confidence: 99%

Transepidermal elimination in cutaneous leishmaniasis: a multiregional study

et al. 2012

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We report the largest multiregional cutaneous leishmaniasis series with a 28.3% documented transepidermal elimination incidence of which 48% were perforating plug; a significant prevalence of L. major was also identified in the transepidermal elimination group. The association of transepidermal elimination with interface changes and a higher parasitic index, without an increased ulceration rate, may reflect a unique biologic alteration in the epidermis, serving to facilitate the extrusion of the parasites through the skin.

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Section: Discussionmentioning

confidence: 99%

Transepidermal elimination in cutaneous leishmaniasis: a multiregional study

et al. 2012

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“…Over the last two decades, the four major perforating disorders have also been observed in adult patients with CRF and/or DM as well as some other systemic disorders. The authors of these reports used many confusing terms such as EPS, 15 acquired RPC, 16 reactive perforating collagenosis of DM and renal failure, 17 PF, 14 PF of haemodialysis, 18 KD, 19 Kyrle‐like lesions, 20 uremic follicular hyperkeratosis, 21 and perforating pseudoxanthoma elasticum 22 . Later on, because of the close clinical and histopathological resemblance among these cases, it was suggested that they are the variants of the same disease process 23 .…”

Section: Discussionmentioning

confidence: 99%

Acquired perforating dermatosis: clinicopathological features in twenty‐two cases

Saray

Seckın

Bilezikçi

2006

Acad Dermatol Venereol

166

197

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Background The term of acquired perforating dermatosis (APD) comprises the perforating dermatoses occurring in adult patients. Clinical and histological features of the disease are not uniform, and may resemble any of the four classic perforating disorders: elastosis perforans serpiginosa, reactive perforating collagenosis, perforating folliculitis or Kyrle's disease. Chronic renal failure and/ or diabetes mellitus usually accompany this skin disease. Objective The aim of this study was to delineate the clinical and histopathological features of acquired perforating dermatosis and to investigate the potential relationship between this disease and associated conditions. Methods Twenty-two patients with acquired perforating dermatosis were enrolled in this study. Clinical findings of acquired perforating dermatosis and the spectrum of associated diseases were investigated. Haematoxylin and eosin sections were re-examined, and immunohistochemical stainings (elastic van Gieson and Masson trichrome stains) and periodic acid-Schiff stain were also used for histopathological evaluation. Results Different clinical types of lesions resembling reactive perforating collagenosis, perforating folliculitis or Kyrle's disease were observed. Histopathological features were consistent with any of the four types of perforating dermatoses. Most of the patients (86.4%) had at least one systemic disease. Chronic renal failure (72.7%) and diabetes mellitus (50%) were the most commonly associated conditions. Most of the patients with diabetes mellitus (90.9%) had chronic renal failure due to diabetic nephropathy. All of the patients with chronic renal failure were on dialysis treatment. The other associated conditions were hepatitis (27.3%), anti-HCV Ab-positivity (13.6%), hypothyroidism (9.1%) and tuberculosis lymphadenitis (4.5%). Of the 22 patients, 13.6% were otherwise healthy, and 9.1% were renal transplant recipients. Conclusion Clinicopathological findings of our study indicate that the cases with APD represent the broad spectrum of perforating disorders rather than the variants of the same disease. Although APD is frequently associated with diabetes mellitus and chronic renal failure, this skin disorder may also develop in patients with other systemic disorders, and in those without any medical problems. This skin disease is probably linked to dialysis treatment in patients with chronic renal failure due to diabetes mellitus or other causes.

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“…Perforating folliculitis (2) c. Blastomycosis (13) c. Amyloid (13) 5. Secondary to CRF and/or DM (2,(52)(53)(54)(55)(56)(57)(58)(59) d. Cryptococcosis (13) d. Ochronotic pigment (25) e. Leischmaniasis (13) e. Elastic fibres (12, 16) f. Histoplasmosis (17) f. Steroids (15) 31 May 1998. Three-mmthick sections were cut from archival paraffin wax blocks and stained with haematoxylin and eosin (H& E), giemsa and silver (Warthin Starry) stains.…”

Section: Methodsmentioning

confidence: 99%

Transepithelial elimination of cutaneous vulval granuloma inguinale

Ramdial¹,

Kharsany

Reddy³

et al. 2000

J Cutan Pathol

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The inflammatory infiltrate at the epitheliomesenchymal interface, pseudoepitheliomatous hyperplasia, intra-epidermal accumulation and disintegration of neutrophils and histiocytes, and the associated release of lytic enzymes, play important contributory roles in TEE of GI. TEE of infectious agents is a poorly recognised mechanism of spread of infectious diseases and represents a public health hazard. In cutaneous vulval GI, TEE is highlighted as a hitherto unrecognised, potential method of spread of Calymmatobacterium granulomatis.

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Elastosis Perforans Serpiginosa in a Patient With Renal Disease

Cited by 25 publications

References 8 publications

Transepidermal elimination in cutaneous leishmaniasis: a multiregional study

Transepidermal elimination in cutaneous leishmaniasis: a multiregional study

Acquired perforating dermatosis: clinicopathological features in twenty‐two cases

Transepithelial elimination of cutaneous vulval granuloma inguinale

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