2011
DOI: 10.1089/ten.tea.2010.0274
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Elastomeric Osteoconductive Synthetic Scaffolds with Acquired Osteoinductivity Expedite the Repair of Critical Femoral Defects in Rats

Abstract: Regenerative medicine aspires to reduce reliance on or overcome limitations associated with donor tissuemediated repair. Structural bone allografts are commonly used in orthopedic surgery, with a high percentage of graft failure due to poor tissue integration. This problem is aggravated among elderly, those suffering from metabolic conditions, or those undergoing cancer therapies that compromise graft healing. Toward this end, we developed a synthetic graft named FlexBone, in which nanocrystalline hydroxyapati… Show more

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Cited by 31 publications
(52 citation statements)
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“…When loaded with a single dose of 400 ng recombinant human bone morphogenetic protein-2/7 heterodimer (rhBMP-2/7) and press-fit into a 5-mm rat femoral segmental defect, the composite facilitated both the formation of fully bridged bony callus in 8 to 12 weeks and the restoration of torsional rigidity by 12 weeks [8]. Furthermore, up to 4.8 wt% vancomycin can be encapsulated within pHEMA-nHA without significantly compromising the structural integrity or the elasticity of the composite graft [17].…”
Section: Introductionmentioning
confidence: 99%
“…When loaded with a single dose of 400 ng recombinant human bone morphogenetic protein-2/7 heterodimer (rhBMP-2/7) and press-fit into a 5-mm rat femoral segmental defect, the composite facilitated both the formation of fully bridged bony callus in 8 to 12 weeks and the restoration of torsional rigidity by 12 weeks [8]. Furthermore, up to 4.8 wt% vancomycin can be encapsulated within pHEMA-nHA without significantly compromising the structural integrity or the elasticity of the composite graft [17].…”
Section: Introductionmentioning
confidence: 99%
“…Torque to failure and stiffness both were lower in the infection group than in the control group at 6 weeks, but with the numbers available for testing, they were not different at 3 weeks (p = 0.615 and p = 1, respectively; Table 2 [3][4][5][6][7][8][9][10][11][12][13][14][15][16]; p = 0.004) both were greater in the control group than in the group with infection. Maximum torque to failure was lower in the infection group than in the control group at all time points.…”
Section: Resultsmentioning
confidence: 99%
“…Rat osteosynthesis models have previously used open incisions and stabilization with plates or external fixator systems [4,8,9,17]. Although these systems are commonly associated with gap osteotomy models, a fracture model could be similarly achieved by making a single saw cut (rather than two needed for a gap osteotomy).…”
Section: Discussionmentioning
confidence: 99%
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“…Thus, HA has long been recognized as an important design element for tissue-engineered bone substitutes (El-Ghannam, 2005). The intrinsic affinity of the dynamic apatite crystal surfaces for many acidic non-collagenous proteins widely found in calcified tissues (George et al, 1996;Gilbert et al, 2000;Stubbs et al, 1997) have also inspired the use of bioceramic scaffolds (Le Nihouannen et al, 2008) or polymer-bioceramics composite scaffolds (Abarrategi et al, 2008;Filion et al, 2011;Xu et al, 2009) to retain and deliver recombinant proteins for therapeutic uses. Overall, HA has been explored for bone tissue engineering applications more as a way to enhance the mechanical strength than as a tool to mediate the biochemical properties of the scaffold (Stevens, 2008;.…”
Section: Key Structural Elements Of Bone and Their Multifaceted Functmentioning
confidence: 99%