Elastography for breast cancer diagnosis using radiation force: System development and performance evaluation

Melodelima, David; Bamber, Jeffrey C.; Duck, Francis; Shipley, Jacqueline; Xu, Lijun

doi:10.1016/j.ultrasmedbio.2005.12.003

Cited by 36 publications

(19 citation statements)

References 46 publications

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“…Indeed, the relevant commercial and scientific literature reveals that both manufacturers and researchers alike have designed ultrasound elastography TMMs to match the acoustic properties of soft tissue with some integration of the mechanical properties of soft tissue. [21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37] Questions still remain, however, as to the efficacy and suitability of such TMMs for their intended purposes. Table 2 presents a list of suggested tissue mimicking properties matched to specific clinical applications, based on measured mechanical properties reported in a number of clinical studies.…”

Section: Relevant Standards and Design Criteriamentioning

confidence: 99%

“…27,28 The Young's modulus values produced by these agar and gelatin dispersions have ranged between 5 -135 kPa, a range representative of soft tissue, while the acoustic velocity and attenuation values achieved have ranged between 1492 -1575 m/s and 0.1 -0.52 dB/cm/MHz, respectively, again representative of soft tissue. [26][27][28] Agar and gelatin based materials have proved successful in validating and testing transient elastography using acoustic radiation force impulse , 30 where the produced phantom has contained targets of high stiffness embedded in a lower Young's modulus background material. Another clinical application of this TMM has been the carotid artery, where the mechanical properties of the carotid artery were successfully mimicked for validation of noninvasive strain imaging using gelatin dispersions.…”

Section: Agar and Gelatine Dispersionsmentioning

confidence: 99%

See 1 more Smart Citation

Review of ultrasound elastography quality control and training test phantoms

Cournane

Fagan

Browne³

2011

Ultrasound

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While the rapid development of ultrasound elastography techniques in recent decades has sparked its prompt implementation in the clinical setting adding new diagnostic information to conventional imaging techniques, questions still remain as to its full potential and efficacy in the hospital environment. A limited number of technical studies have objectively assessed the full capabilities of the different elastography approaches, perhaps due, in part, to the scarcity of suitable tissue-mimicking materials (TMMs) and appropriately designed phantoms available. Few commercially available elastography phantoms possess the necessary test target characteristics or mechanical properties observed clinically, or indeed reflect the lesion-to-background elasticity ratio encountered during clinical scanning. Thus, while some phantoms may prove useful, they may not fully challenge the capabilities of the different elastography techniques, proving limited when it comes to quality control (QC) and/or training purposes. Although a variety of elastography TMMs, such as agar and gelatine dispersions, co-polymer in oil and poly(vinyl) alcohol cryogel, have been developed for specific research purposes, such work is yet to produce appropriately designed phantoms to adequately challenge the variety of current commercially available elastography applications. Accordingly, there is a clear need for the further development of elastography TMMs and phantoms to keep pace with the rapid developments in elastography technology, to ensure that the performance of these new diagnostic approaches are validated, and for clinical training purposes.

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Section: Relevant Standards and Design Criteriamentioning

confidence: 99%

Section: Agar and Gelatine Dispersionsmentioning

confidence: 99%

Review of ultrasound elastography quality control and training test phantoms

Cournane

Fagan

Browne³

2011

Ultrasound

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“…It requires no extra hardware and is based on a fast-processing software algorithm. US elastography has been used in other areas, including oncology and hepatology, helping in the detection and differentiation of malignant lesions and fibrosis (26)(27)(28)(29)(30)(31)(32).…”

Section: Us Elastographymentioning

confidence: 99%

Skin imaging in systemic sclerosis

Kang¹,

Abignano²,

Lettieri³

et al. 2014

Eur J Rheumatol

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Fibrotic involvement of the skin is a cardinal feature of systemic sclerosis (SSc). The extent of skin involvement is associated with internal organ involvement, coinciding with more severe disease course and poor prognosis. A palpation-based semi-quantitative score, the modified Rodnan skin score, is widely used for the assessment of skin involvement, but it is entailed by significant limitations. More objective approaches to measure skin involvement employing imaging have been explored continuously in the past decades and are currently advancing. Here, we review the use of different imaging techniques for the assessment of skin involvement in patients with SSc, focusing mainly on ultrasound, magnetic resonance imaging, and optical coherence tomography.

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“…However, ultrasound lacks spatial resolution, cannot image calcifications and is very operator dependent. Breast cancer is relatively iso-echoic [8] (that is, the echo similarity of two or more tissues as measured by ultrasonography) and hence, difficult to detect by ultrasound. Thus, unnecessary biopsies are needed on benign masses [8].…”

Section: Introductionmentioning

confidence: 99%