Elastography: A Quantitative Method for Imaging the Elasticity of Biological Tissues

Ophir, Jonathan; Céspedes, I.; Ponnekanti, H.; Yazdi, Youseph; Li, X.

doi:10.1177/016173469101300201

Cited by 2,686 publications

(1,292 citation statements)

References 25 publications

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“…Several USE methods have been developed, including quasi-static elastography (QSE) or strain elastography and share-wave elastography (1,2,5,10).…”

Section: Discussionmentioning

confidence: 99%

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Value of Real-Time and Strain Ratio Elastography in Differential Diagnosis of Graves’ Disease and Subacute and Hashimoto’s Thyroiditis

Korkmaz¹,

Baki²,

Köse³

et al. 2017

Iran J Radiol

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Objectives: The main purpose of the present study was to determine the efficacy of real-time elastography (RTE) and strain elastography (STE) in the diagnosis of different thyroid diseases. We also aimed to calculate the cut-off points for the differential diagnosis of subacute thyroiditis (SAT), Graves' disease (GD), and Hashimoto's thyroiditis (HT), which have a similar B-mode sonographic appearance. Patients and Methods: A total of 24 patients with GD (10.9%), 94 patients with HT (42.7%), 20 patients with SAT (9.1%), and 82 individuals with normal healthy thyroids (37.3%) were included. Grayscale ultrasound evaluation of thyroid glands was performed with standard transverse and longitudinal planes before sonoelastography. Results:The strain ratios (SRs) (mean ± standard deviation) of patients with GD, HT, and SAT, and the control group (CG) were 14.7 ± 14.8, 8.4 ± 9.6, 23.2 ± 10.8, and 1.37 ± 0.8, respectively. The cut-off points of strain elastography of the patients with GD, HT, and SAT to the CG were 2.69 (sensitivity 92%, specificity 90%, area under the curve (AUC) 0.983; 95% CI), 2.18 (sensitivity 100%, specificity 85%, AUC 0.898), and 5.54 (sensitivity 100%, specificity 100%, AUC 1.000; 95% CI), respectively. The cut-off point of the strain ratios (SR) of the total amount of patients with HT and GD to SAT was 14.79 (sensitivity 80%, specificity 85%, AUC 0.869; 95% CI). Conclusion: Statistically significant differences were noted in the SR values and elasticity scores of the three experimental groups, and the CG. The elasticity scores of the SAT and HT groups were not significantly different from those of the GD group. The diagnostic performance of strain ratio elastography (P < 0.0001) was higher than that of real time elastography (P < 0.001). In terms of differentiating diagnosis, ES could differentiate SAT from HT, but it had no value in differentiating GD from HT and SAT. We also found statistically significant SRs for the differential diagnosis of SAT from GD and HT. Strain elastography could be a useful method for the differential diagnosis of SAT from a healthy population or from other types of thyroiditis such as GD and HT.

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“…Several USE methods have been developed, including quasi-static elastography (QSE) or strain elastography and share-wave elastography (1,2,5,10).…”

Section: Discussionmentioning

confidence: 99%

“…Sonoelastography (USE) has replaced palpation in thyroid examination, and it was first used by Ophir (1).…”

Section: Introductionmentioning

confidence: 99%

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Value of Real-Time and Strain Ratio Elastography in Differential Diagnosis of Graves’ Disease and Subacute and Hashimoto’s Thyroiditis

Korkmaz¹,

Baki²,

Köse³

et al. 2017

Iran J Radiol

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“…Theoretically, a technique that allows tracking of mechanical waves in tissue and measuring their wavelength would allow for assessment of tissue stiffness (elastic modulus). In 1992, elastography was described as a method that would allow quantitative imaging of strain and the elastic modulus distribution through soft tissues 1. In 1995, elastography was combined with MRI, allowing the spatial mapping and quantification of harmonic mechanical waves in tissues and the visualization of propagating mechanical waves 2…”

Section: What Is Mre?mentioning

confidence: 99%

Premarket Approval Through the 510(k) Process: Lessons from the Translation Process of Magnetic Resonance Elastography

Ortiz

Konik

Eckert

et al. 2018

Clinical Translational Sci

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“…This technique uses the principle that application of stress to the tissue produces a strain (displacement), which is lower in hard tissues and higher in soft tissues. 9,10 There are several elastography techniques which differ according to the type of stress application and to the method used to detect tissue strain and to gain the image of the tissue. These are sonoelastography, shear wave elastography, transient elastography and acoustic radiation force elastography.…”

Section: Introductionmentioning

confidence: 99%

Assessment of forearm muscle spasticity with sonoelastography in patients with stroke

Yaşar

Adıgüzel

Kesikburun

et al. 2016

The British Journal of Radiology

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Objective: The aim of the study was to investigate the feasibility of sonoelastography to show muscle stiffness in post-stroke spasticity, and the relationship between sonoelastography findings and clinical spasticity scores in the spastic forearm muscles. Methods: This study was carried out in a university rehabilitation centre. 23 patients with stroke with forearm muscle spasticity ($11 using the Modified Ashworth scale score and $1 using the Tardieu scale) were included. Sonoelastography parameters (elasticity index and elasticity ratio) were measured from the flexor digitorum superficialis, flexor digitorum profundus, flexor carpi radialis and flexor carpi ulnaris muscles on the affected and unaffected sides. Results: Both elasticity index and elasticity ratio of the wrist and finger flexors on the hemiplegic side were significantly increased compared with those on the healthy side (p , 0.05). The Tardieu angle of finger flexors was negatively correlated with the elasticity index and elasticity ratio measured in the spastic flexor digitorum profundus (r 5 20.418 and r 5 20.469, respectively). Tardieu angle of finger flexors was negatively correlated with the elasticity index measured in the spastic flexor digitorum superficialis (r 5 20.435). There was no correlation between other parameters. Conclusion: Sonoelastography may provide objective assessment of spasticity both in diagnosis and followup. To strengthen this prediction, further studies are necessary. Advances in knowledge:The results of this study represent that sonoelastography is a promising evaluation method for forearm muscle spasticity.

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Elastography: A Quantitative Method for Imaging the Elasticity of Biological Tissues

Cited by 2,686 publications

References 25 publications

Value of Real-Time and Strain Ratio Elastography in Differential Diagnosis of Graves’ Disease and Subacute and Hashimoto’s Thyroiditis

Value of Real-Time and Strain Ratio Elastography in Differential Diagnosis of Graves’ Disease and Subacute and Hashimoto’s Thyroiditis

Premarket Approval Through the 510(k) Process: Lessons from the Translation Process of Magnetic Resonance Elastography

Assessment of forearm muscle spasticity with sonoelastography in patients with stroke

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