Elastoderma of the neck in a teenage boy

Vieira, Ana Cristina Trench; Vieira, Wilma Trench; Michalany, Nílceo Schwery; Enokihara, Mauro; Freymüller, Edna; Cestari, Silmara da Costa Pereira

doi:10.1016/j.jaad.2005.01.005

Cited by 9 publications

(3 citation statements)

References 8 publications

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“…Elastoderma is an exceedingly rare condition presenting with an acquired localized laxity of skin resembling cutis laxa, with an abundance of pleomorphic elastic tissue in the dermis [127, 128]. It has been suggested that the abundance of elastic tissue results from increased synthesis, as evidenced by the presence of active fibroblasts with prominent rough endoplasmic reticulum [127–129].…”

Section: Related Dermatological Diseasesmentioning

confidence: 99%

Histopathology of Pseudoxanthoma Elasticum and Related Disorders: Histological Hallmarks and Diagnostic Clues

2012

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Among ectopic mineralization disorders, pseudoxanthoma elasticum (PXE)—a rare genodermatosis associated with ocular and cardiovascular manifestations—is considered a paradigm disease. The symptoms of PXE are the result of mineralization and fragmentation of elastic fibers, the exact pathophysiology of which is incompletely understood. Though molecular analysis of the causal gene, ABCC6, has a high mutation uptake, a skin biopsy has until now been considered the golden standard to confirm the clinical diagnosis. Although the histological hallmarks of PXE are rather specific, several other diseases—particularly those affecting the skin—can present with clinical and/or histological characteristics identical to or highly resemblant of PXE. In this paper, we will summarize the histopathological features of PXE together with those of disorders that are most frequently considered in the differential diagnosis of PXE.

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Section: Related Dermatological Diseasesmentioning

confidence: 99%

Histopathology of Pseudoxanthoma Elasticum and Related Disorders: Histological Hallmarks and Diagnostic Clues

2012

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“…Since then, 3 other cases have been reported with similar findings of focal areas of lax wrinkled skin on the neck, elbows, and knees with delayed recoil 2 (Table 1). 4 Transmission electron microscopy shows fibroblast-like cells with prominent rough endoplasmic reticulum and irregular deposits of elastic material at the periphery of elastic tissue fibers, with grape-like globular structures. 5 There is no evidence of calcification.…”

Section: Discussionmentioning

confidence: 99%

“…Histologically, it is characterized by a decrease of elastic fibers in the dermis; remaining fibers are often shortened and fragmented, and there is a variable inflammatory infiltrate. 2,4 The diagnosis of elastoderma was discussed with our patient and possible treatment options including excision, and she has deferred. This may be a primary process or may follow an inflammatory process.…”

Section: Discussionmentioning

confidence: 99%

Elastoderma

Adil

Walsh²

2015

The American Journal of Dermatopathology

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Elastoderma is a rare cutaneous condition, which clinically presents as an acquired laxity and decreased recoil of skin. It is histologically characterized by an increase of pleomorphic and fragmented elastic fibers in the superficial dermis. A case of a 61-year-old woman with wrinkled lax skin on the anterior and lateral aspects of her neck was reported. Microscopic examination revealed an accumulation of fragmented curled elastic fibers in the dermis. This is the fifth reported case of elastoderma.

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Age-Related Changes in Skin Mechanical Properties

Krueger

Luebberding

2015

Textbook of Aging Skin

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Elastoderma of the neck in a teenage boy

Cited by 9 publications

References 8 publications

Histopathology of Pseudoxanthoma Elasticum and Related Disorders: Histological Hallmarks and Diagnostic Clues

Histopathology of Pseudoxanthoma Elasticum and Related Disorders: Histological Hallmarks and Diagnostic Clues

Elastoderma

Age-Related Changes in Skin Mechanical Properties

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