Elastin turnover in ocular diseases: A special focus on age-related macular degeneration

Navneet, Soumya; Rohrer, Bärbel

doi:10.1016/j.exer.2022.109164

Cited by 7 publications

(3 citation statements)

References 181 publications

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“…BrM undergoes significant age-related changes, including thickening and decreased permeability, that disrupt normal retinal physiology and contribute to AMD [ 102 ]. One of its five differentiated layers is composed mainly of elastin [ 103 ]. It has been hypothesized that degradation of elastin at the BrM macula is a key event facilitating CNV [ 29 ].…”

Section: Resultsmentioning

confidence: 99%

Recent Advances in Proteomics-Based Approaches to Studying Age-Related Macular Degeneration: A Systematic Review

García-Quintanilla

Rodríguez-Martínez²,

Bandín-Vilar

et al. 2022

IJMS

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Age-related macular degeneration (AMD) is a common ocular disease characterized by degeneration of the central area of the retina in the elderly population. Progression and response to treatment are influenced by genetic and non-genetic factors. Proteomics is a powerful tool to study, at the molecular level, the mechanisms underlying the progression of the disease, to identify new therapeutic targets and to establish biomarkers to monitor progression and treatment effectiveness. In this work, we systematically review the use of proteomics-based approaches for the study of the molecular mechanisms underlying the development of AMD, as well as the progression of the disease and on-treatment patient monitoring. The Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) reporting guidelines were followed. Proteomic approaches have identified key players in the onset of the disease, such as complement components and proteins involved in lipid metabolism and oxidative stress, but also in the progression to advanced stages, including factors related to extracellular matrix integrity and angiogenesis. Although anti-vascular endothelial growth factor (anti-VEGF)-based therapy has been crucial in the treatment of neovascular AMD, it is necessary to deepen our understanding of the underlying disease mechanisms to move forward to next-generation therapies for later-stage forms of this multifactorial disease.

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Section: Resultsmentioning

confidence: 99%

Recent Advances in Proteomics-Based Approaches to Studying Age-Related Macular Degeneration: A Systematic Review

García-Quintanilla

Rodríguez-Martínez²,

Bandín-Vilar

et al. 2022

IJMS

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“…79 In addition, Müller glia also express proteases, such as MMP-9 and HTRA1, 43 which are major contributing factors in extracellular matrix turnover and the pathogenesis of AMD. [80][81][82] Increased plasma levels of MMP-9 have been associated with neovascular AMD, 83 and genetic polymorphisms near MMP-9 were explicitly linked to CNV in a large genomewide association study (GWAS). 84 These findings suggest that Müller cells may also play a critical role in extracellular matrix remodeling in AMD, a hypothesis that warrants further studies.…”

Section: Secretory Role Of Müller Glia In Health and Diseasementioning

confidence: 99%

Müller Glial Cells in the Macula: Their Activation and Cell-Cell Interactions in Age-Related Macular Degeneration

Navneet,

Wilson,

Rohrer

2024

Invest. Ophthalmol. Vis. Sci.

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Müller glia, the main glial cell of the retina, are critical for neuronal and vascular homeostasis in the retina. During age-related macular degeneration (AMD) pathogenesis, Müller glial activation, remodeling, and migrations are reported in the areas of retinal pigment epithelial (RPE) degeneration, photoreceptor loss, and choroidal neovascularization (CNV) lesions. Despite this evidence indicating glial activation localized to the regions of AMD pathogenesis, it is unclear whether these glial responses contribute to AMD pathology or occur merely as a bystander effect. In this review, we summarize how Müller glia are affected in AMD retinas and share a prospect on how Müller glial stress might directly contribute to the pathogenesis of AMD. The goal of this review is to highlight the need for future studies investigating the Müller cell's role in AMD. This may lead to a better understanding of AMD pathology, including the conversion from dry to wet AMD, which has no effective therapy currently and may shed light on drug intolerance and resistance to current treatments.

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“…BrM undergoes significant age-related changes, including thickening and decreased permeability, that disrupts normal retinal physiology and contributes to AMD [73]. One of its five differentiated layers is composed mainly of elastin [74]. It has been hypothesized that degradation of elastin at the BrM macula is a key event facilitating CNV [29].…”

Section: Proteomics On Bruch´s Membrane In Amdmentioning

confidence: 99%

Recent Advances in Proteomic-based Approaches to Study Age-related Macular Degeneration: A Systematic Review

García-Quintanilla¹,

Rodríguez-Martínez²,

Bandín-Vilar³

et al. 2022

Preprint

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Age-related macular degeneration (AMD) is a common ocular disease characterized by the de-generation of the central area of the retina in elderly population. Progression and response to treatment is influenced by genetic and non-genetic factors. Proteomics is a powerful tool to study, at the molecular level, the mechanisms underlaying the progression of the diseases, to identify new therapeutical targets and to establish biomarkers to monitor progression and treatment ef-fectiveness. In this work we pursue to systematically review the use of proteomic-based ap-proaches for the study of the molecular mechanisms underlying the development of AMD, as well as the progression of the disease and the on-treatment patient monitoring. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) reporting guidelines were followed. Proteomic approaches have identified key players on the onset of the disease, such as proteins involved in lipid metabolism and oxidative stress, but also in the progression to advanced stages, including factors related to extracellular matrix integrity and angiogenesis. Although an-ti-vascular endothelial growth factor (anti-VEGF)-based therapy has been crucial in the treatment of neovascular AMD it is necessary to get deeper into the underlying disease mechanisms to move forward to next-generation therapies of the later-stage forms of this multifactorial disease.

show abstract

Elastin turnover in ocular diseases: A special focus on age-related macular degeneration

Cited by 7 publications

References 181 publications

Recent Advances in Proteomics-Based Approaches to Studying Age-Related Macular Degeneration: A Systematic Review

Recent Advances in Proteomics-Based Approaches to Studying Age-Related Macular Degeneration: A Systematic Review

Müller Glial Cells in the Macula: Their Activation and Cell-Cell Interactions in Age-Related Macular Degeneration

Recent Advances in Proteomic-based Approaches to Study Age-related Macular Degeneration: A Systematic Review

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