Elastin staining patterns in primary cicatricial alopecia

Fung, Maxwell A.; Sharon, Victoria R.; Ratnarathorn, Mondhipa; Konia, Thomas; Barr, Keira; Mirmirani, Paradi

doi:10.1016/j.jaad.2013.07.018

Cited by 30 publications

(16 citation statements)

References 18 publications

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“…When biopsy specimens of active lesions are nondiagnostic, a biopsy specimen from a scarred area can be helpful diagnostically when evaluated with elastic tissue stains or polarized microscopy. [23][24][25][26] Chronic cutaneous LE produces broad areas of scarring, whereas lichen planopilaris and folliculitis decalvans produce focal wedge-shaped scars at the level of the follicular infundibulum. Central elliptical alopecia of black women (the major form of central centrifugal cicatricial alopecia) is characterized by broad fibrous tract remnants with retention of the surrounding elastic sheath, contraction of the dermis, and thick recoiled elastic fibers.…”

Section: Panniculitismentioning

confidence: 99%

Skin biopsy

Elston

Stratman

Miller

2016

Journal of the American Academy of Dermatology

119

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Misdiagnosis may result from biopsy site selection, technique, or choice of transport media. Important potential sources of error include false-negative direct immunofluorescence results based on poor site selection, uninformative biopsy specimens based on both site selection and technique, and spurious interpretations of pigmented lesions and nonmelanoma skin cancer based on biopsy technique. Part I of this 2-part continuing medical education article addresses common pitfalls involving site selection and biopsy technique in the diagnosis of bullous diseases, vasculitis, panniculitis, connective tissue diseases, drug eruptions, graft-versus-host disease, staphylococcal scalded skin syndrome, hair disorders, and neoplastic disorders. Understanding these potential pitfalls can result in improved diagnostic yield and patient outcomes.

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Section: Panniculitismentioning

confidence: 99%

Skin biopsy

Elston

Stratman

Miller

2016

Journal of the American Academy of Dermatology

119

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“…Apoptosis was not detected during expanding skin and histological results showed that porous area were increased in the expanded skin dermis (Fig. 3) [18,20]. During skin expansion, internal micro-structure of skin looks loosened as the arrangements of collagen and elastin were altered.…”

Section: Discussionmentioning

confidence: 97%

Rapid expansion and auto-grafting efficiency of porcine full skin expanded by a skin bioreactor ex vivo

Huh

Kim

et al. 2016

Tissue Eng Regen Med

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Full skin auto-grafts are required for reconstruction of skin burns and trauma scars. However, currently available clinical approaches such as sheet skin graft, mesh skin grafts, artificial skin graft, and in vivo skin expansion have limitations due to their potential danger for secondary damage and scar formation at the donor site, and discomfort during skin expansion. We developed an advanced bioreactor system and evaluated its function in skin expansion using porcine full skin. The reactor was designed as a pneumatic cylinder type, was programmed to adjust the pressure and the operating time. The system was composed of culture chamber unit, environmental control unit, and monitoring unit. Skins were expanded at 200 kPa pneumatic force and the expanded skins were analyzed by immunohistochemistry and histology. Furthermore we carried out auto-grafting experiment of the expanded skins in vivo using Yucatan pigs and skins were harvested and histologically analyzed after 8 weeks. The results showed that the bioreactor expanded skins to 160% in 4 hours. Histological analysis of the expanded skins revealed that epidermal cells and dermal fibroblasts were viable and remained integrity. The results of auto-grafting experiment indicated that fibrosis and scars were not detected in the grafted skins. This study demonstrates that the newly developed skin bioreactor enabled to obtain large sized full skin rapidly and successful grating.

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“…With time, FD tends to develop clinical and dermoscopic features of lichen planopilaris (LPP). More important tufting, and on histopathology, a more diffuse pattern of effaced dermal elastic fibers versus selective loss of elastic fibers at the site of selectively destroyed hair follicles,[ 26 ] in combination with a more important number of plasma cells in the inflammatory infiltrate,[ 27 ] helps distinguish late phases of FD from LPP. It can be assumed that through the destruction of hair follicles in the course of the primary infectious disease, follicular antigens are exposed and give rise to an autoimmune reaction.…”

Section: Discussionmentioning

confidence: 99%

“…On histopathological examination, the dermal elastic network remains preserved. [ 26 ] The cause is unknown although reports of morphea coexisting with other systemic autoimmune diseases support that morphea is also a condition of autoimmune origin. It has been proposed that linear morphea follows Blaschko's lines, giving rise to the hypothesis that in patients with linear morphea, susceptible cells are present in a mosaic state, and exposure to some trigger factor, including trauma, may result in the development of this condition.…”

Section: Discussionmentioning

confidence: 99%

Linear circumscribed scleroderma-like folliculitis decalvans: Yet another face of a protean condition

Rezende

Dias

Kempf³

et al. 2018

Int J Trichol

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Since Quinquaud's original report of folliculitis decalvans (FD), further clinical variants have been described on the basis of common histopathological and microbiological findings. Histopathology reveals a neutrophilic primary scarring alopecia, and microbiological studies invariably reveal pathogenic strains of Staphylococcus aureus. The presence of thickening of lesional skin in FD has been previously described. We report a new presentation of FD, clinically mimicking linear circumscribed scleroderma of the scalp. Overlapping features of the scarring alopecias may blur the distinction between different conditions that ultimately share the common final pathway of replacement of follicle by fibrous tissue. Therefore, a careful patient history, clinical examination including dermoscopy, microbiological studies, and a scalp biopsy for histopathology, and immunofluorescence studies are prerequisites to an accurate diagnosis and appropriate treatment of the respective condition. The case is presented to illustrate the clinical variability in presentation of FD and to underline the necessity of performing a biopsy for an accurate diagnosis in the scarring alopecias.

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Elastin staining patterns in primary cicatricial alopecia

Cited by 30 publications

References 18 publications

Skin biopsy

Skin biopsy

Rapid expansion and auto-grafting efficiency of porcine full skin expanded by a skin bioreactor ex vivo

Linear circumscribed scleroderma-like folliculitis decalvans: Yet another face of a protean condition

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