Elastin-lipid Interaction in Arterial Wall

昭夫, 野間; とよ子, 平山; 裕治, 日野田; 昭, 谷内

doi:10.5551/jat1973.10.2_305

Cited by 1 publication

(1 citation statement)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, Noma and coworkers 11 found a far greater amount of LDL binding to elastin than we observed, indicating that different mechanisms might be operative. 9 The reason for the slower phase of LDL binding to elastin, evident at temperatures above 4°C, is unclear. In some of the studies previously reported, which were generally performed over 24 hours, a majority of the LDL binding appears to have occurred during this slower phase.…”

Section: Discussionmentioning

confidence: 99%

Interaction of low density lipoproteins with human aortic elastin.

Podet

Shaffer

Gianturco

et al. 1991

Arterioscler Thromb

View full text Add to dashboard Cite

Binding of radioiodinated low density lipoprotein (LDL) to isolated elastin has been studied in several laboratories.7 -12 However, these studies often involved prolonged incubation periods (18-24 hours) at 21°C or 37°C, and a complex interaction was indicated by continued uptake of LDL by elastin throughout the incubation period. An affinity con- Supported by grant HL-29680 and Research Career Development Award HL-02114 (to J.R.G.) from the National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md.Address for correspondence: John R. Guyton, MD, The Methodist Hospital, A-601, 6565 Fannin Street, Houston, TX 77030. Received June 8, 1989; revision accepted July 11, 1990. stant for LDL-elastin interaction has not been determined previously.In this article, we report studies of the interaction of radioiodinated human plasma LDL with human aortic elastin, focusing especially on temperature/ time dependence and affinity. We have also investigated the specificity of the interaction and the binding of LDL to elastin isolated from atherosclerotic plaques. Elastin preparations were characterized by amino acid analysis, electron microscopy, and measurement of calcium, hexosamine, and sulfate.

show abstract

Section: Discussionmentioning

confidence: 99%