Elastin‐Like Macromolecules

Costa, Rui R.; Martin, Laura B.; Mano, João F.; Rodríguez‐Cabello, José Carlos

doi:10.1002/9783527652273.ch5

Cited by 7 publications

(3 citation statements)

References 174 publications

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“…Chitosan-based capsules can also be synthesized resorting to electrostatic complexation, and, in some cases, are able to respond to external stimuli other than pH. One such example is the conception of LbL microcapsules made by complexation of chitosan with negatively charged elastin-like recombinamers (ELRs), recombinant polypeptides with intrinsic response towards temperature [ 181 ]. Novel thermoresponsive ELR/chitosan microcapsules were developed for the delivery of active molecules [ 182 ].…”

Section: Polysaccharides From Marine Animalsmentioning

confidence: 99%

Marine Origin Polysaccharides in Drug Delivery Systems

2016

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Oceans are a vast source of natural substances. In them, we find various compounds with wide biotechnological and biomedical applicabilities. The exploitation of the sea as a renewable source of biocompounds can have a positive impact on the development of new systems and devices for biomedical applications. Marine polysaccharides are among the most abundant materials in the seas, which contributes to a decrease of the extraction costs, besides their solubility behavior in aqueous solvents and extraction media, and their interaction with other biocompounds. Polysaccharides such as alginate, carrageenan and fucoidan can be extracted from algae, whereas chitosan and hyaluronan can be obtained from animal sources. Most marine polysaccharides have important biological properties such as biocompatibility, biodegradability, and anti-inflammatory activity, as well as adhesive and antimicrobial actions. Moreover, they can be modified in order to allow processing them into various shapes and sizes and may exhibit response dependence to external stimuli, such as pH and temperature. Due to these properties, these biomaterials have been studied as raw material for the construction of carrier devices for drugs, including particles, capsules and hydrogels. The devices are designed to achieve a controlled release of therapeutic agents in an attempt to fight against serious diseases, and to be used in advanced therapies, such as gene delivery or regenerative medicine.

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Section: Polysaccharides From Marine Animalsmentioning

confidence: 99%

Marine Origin Polysaccharides in Drug Delivery Systems

2016

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“…Elastic fibres are present in all those tissues that require the recovery of their initial shape after deformation, such as skin, ligaments and blood vessels [192]. The main components of elastic fibres are elastin and microfibrils.…”

Section: Elastinmentioning

confidence: 99%

Natural polymers for the microencapsulation of cells

Gasperini

Mano

Reis

2014

J. R. Soc. Interface.

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526

413

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The encapsulation of living mammalian cells within a semi-permeable hydrogel matrix is an attractive procedure for many biomedical and biotechnological applications, such as xenotransplantation, maintenance of stem cell phenotype and bioprinting of three-dimensional scaffolds for tissue engineering and regenerative medicine. In this review, we focus on naturally derived polymers that can form hydrogels under mild conditions and that are thus capable of entrapping cells within controlled volumes. Our emphasis will be on polysaccharides and proteins, including agarose, alginate, carrageenan, chitosan, gellan gum, hyaluronic acid, collagen, elastin, gelatin, fibrin and silk fibroin. We also discuss the technologies commonly employed to encapsulate cells in these hydrogels, with particular attention on microencapsulation.

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“…Elastin-like macromolecules are genetically engineered materials rooted in the repeating sequence of natural elastin. 53 PLGA: Poly(lactic-co-glycolic acid); FGF: Fibroblast growth factor; IGF: Insulin-like growth factor; NGF: Nerve growth factor; PDFG: Platelet-derived growth factor; TGF:…”

Section: Collagen and Gelatinmentioning

confidence: 99%

2.11 Polymers of Biological Origin ☆

Silva

Fernandes

Pina

et al. 2017

Comprehensive Biomaterials II

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Recent advances in tissue engineering and regenerative medicine have shown that combining biomaterials, cells, and bioactive molecules are important to promote the regeneration of damaged tissues or as therapeutic systems. Natural origin polymers have been used as matrices in such applications due to their biocompatibility and biodegradability. This chapter provides an up-to-date review on the most promising natural biopolymers, focused on polysaccharides and proteins, their properties and applications. Membranes, micro/ nanoparticles, scaffolds, and hydrogels as biomimetic strategies for tissue engineering and processing are described, along with the use of bioactive molecules and growth factors to improve tissue regeneration potential. Finally, current biomedical applications are also presented.

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Elastin‐Like Macromolecules

Cited by 7 publications

References 174 publications

Marine Origin Polysaccharides in Drug Delivery Systems

Marine Origin Polysaccharides in Drug Delivery Systems

Natural polymers for the microencapsulation of cells

2.11 Polymers of Biological Origin ☆

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