Elastin in Blood Vessels

Robert, L.; Jacob, Marie‐Paule; Fulop, T

doi:10.1002/9780470514771.ch15

Cited by 25 publications

(24 citation statements)

References 34 publications

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“…elastin provides elastic recoil and passively sustains the mechanical stress of pulsation. 26,27 Over time, the elastic lamellae become increasingly fragmented and fibrotic, particularly in hypertensive patients. 28 elastin degradation products are called elastin peptides.…”

Section: Elastinmentioning

confidence: 99%

Biomarkers of AAA progression. Part 1: extracellular matrix degeneration

et al. 2009

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Abdominal aortic aneurysm (AAA) is an important health problem. Elective surgical treatment is recommended on the basis of an individual's risk of rupture, which is predicted by AAA diameter. However, the natural history of AAA differs between patients and a reliable and individual predictor of AAA progression (growth and expansion rates) has not been established. Several circulating biomarkers are candidates for an AAA diagnostic tool. However, they have yet to meet the triad of biomarker criteria: biological plausibility, correlation with AAA progression, and prediction of treatment effect on disease outcome. Circulating levels of markers of extracellular matrix degeneration, such as elastin peptides, aminoterminal propeptide of type III procollagen, elastase-alpha1-antitrypsin complexes, matrix metalloproteinase 9, cystatin C, plasmin-antiplasmin complexes and tissue plasminogen activator, have been correlated with AAA progression and have biological plausibility. Although studies of these markers have shown promising results, they have not yet led to a clinically applicable biomarker. In future studies, adjustment for initial AAA size, smoking history and the measurement error for determination of AAA size, among other variables, should be taken into account. A large, prospective, standardized, follow-up study will be needed to investigate multiple circulating biomarkers for their potential role in the prediction of AAA progression, followed by a study to investigate the effect of treatment on the circulating levels of biomarkers.

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Section: Elastinmentioning

confidence: 99%

Biomarkers of AAA progression. Part 1: extracellular matrix degeneration

et al. 2009

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“…The prime importance of elastin lies in its function ability to impart elasticity to the tissue [71]. Recently, it has been revealed that elastin has a wider range of function, such as its involvement in the recruitment of inflammatory cells and/or vasodilatation [72].…”

Section: Extracellular Matrix Components Mesenchymementioning

confidence: 99%

Preservation, sterilization and de-epithelialization of human amniotic membrane for use in ocular surface reconstruction

et al. 2010

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“…Marfan syndrome is known to be associated with mutations in the fibrillin 1 (FBN1) gene (85). Fibrillin forms an essential element of the microfibrils that surround the elastin fibers, for maintaining vessel wall integrity (86). The FBN1 gene is homologous with the family of latent transforming growth factor-beta (TGF-b)-binding proteins, which maintains TGF-b in an inactive complex.…”

Section: Pathogenesis and Etiologymentioning

confidence: 99%

Coronary Artery Aneurysms: A Review of the Epidemiology, Pathophysiology, Diagnosis, and Treatment

Sherif

Tok

Taşköylü

et al. 2017

Front. Cardiovasc. Med.

198

189

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Coronary artery aneurysms (CAAs) are uncommon and describe a localized dilatation of a coronary artery segment more than 1.5-fold compared with adjacent normal segments. The incidence of CAAs varies from 0.3 to 5.3%. Ever since the dawn of the interventional era, CAAs have been increasingly diagnosed on coronary angiography. Causative factors include atherosclerosis, Takayasu arteritis, congenital disorders, Kawasaki disease (KD), and percutaneous coronary intervention. The natural history of CAAs remains unclear; however, several recent studies have postulated the underlying molecular mechanisms of CAAs, and genome-wide association studies have revealed several genetic predispositions to CAA. Controversies persist regarding the management of CAAs, and emerging findings support the importance of an early diagnosis in patients predisposed to CAAs, such as in children with KD. This review aims to summarize the present knowledge of CAAs and collate the recent advances regarding the epidemiology, etiology, pathophysiology, diagnosis, and treatment of this disease.

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Elastin in Blood Vessels

Cited by 25 publications

References 34 publications

Biomarkers of AAA progression. Part 1: extracellular matrix degeneration

Biomarkers of AAA progression. Part 1: extracellular matrix degeneration

Preservation, sterilization and de-epithelialization of human amniotic membrane for use in ocular surface reconstruction

Coronary Artery Aneurysms: A Review of the Epidemiology, Pathophysiology, Diagnosis, and Treatment

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