Elastin Gene Expression in Blepharochalasis

Kaneoya, Kyoko; Momota, Yutaka; Hatamochi, Atsushi; Matsumoto, Fumiaki; Arima, Yusuke; Shinkai, Hiroshi

doi:10.1111/j.1346-8138.2005.tb00709.x

Cited by 17 publications

(5 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As reported previously, in the late stage of the condition, the loss of elastic bers in the dermis leads to reduced elasticity, and is considered to be a cause of manifestation of blepharochalasis [12,13]. As the eyelids gradually lose their elasticity, some other manifestations would show up, such as thinned and wrinkled eyelids, ptosis, lacrimal gland prolapse, lids retraction, horizontally shortened palpebral ssure or rounded deformity of the lateral canthal angle.…”

Section: Discussionmentioning

confidence: 77%

Blepharochalasis:Clinical and Epidemiological Characteristics, Surgical Strategy and Prognosis-- A Retrospective Cohort Study with 93 Cases

Zhou

Ding

2021

Preprint

View full text Add to dashboard Cite

Background: Blepharochalasis is a rare eyelid disorder but eventually leading to destructive eyelid deformation. Until now the clinical and epidemiological data is unavailable. This study aimed o report the manifestations, epidemiological characteristics and surgical strategy of a large series of blepharochalasis patients with long-term follow up, the prognosis of different clinical deformities was also investigated. Methods: This is a retrospective cohort study, included consecutive patients diagnosed with blepharochalasis in a single center. Blepharoplasty and other surgical approaches were scheduled according to the various manifestations, after a 2-year quiescent period with no recurrent attacks and exacerbation of lesions. Prognosis after surgery was recorded.Results: A total of 93 patients, with a mean follow-up of 5.29±2.07 (range: 3-10) years before surgery, and 2(range:1-4) years follow-up after surgery were included. Of all those 93 patients, 72.04% were females (67, P=0.02 ). The mean age of onset of blepharochalasis symptoms was 10.09±3.32 (range: 5-16) years, mostly (83.87%) consisted with the onset of the puberty. With the average of 5 times per year, the mean duration of each acute attack was 28.12±1.01 (rang: 2-192)hours. The mean duration from the onset of acute attack to the quiescent stage lasted for 7.33 ± 2.05 (range: 4-10) years. Most of the cases (88, 94.62%) had more than one manifestation at the end of the last follow-up before surgery. Ptosis (48.39%) was the most common deformity. Followed by lacrimal gland prolapse (44.09%), canthal angle deformity(29.04%), lower eyelid retraction(17.20%). After surgery, the functional and cosmetically acceptable results were achieved in all patients except for overcorrection in 5 (11.90%) patients with ptosis. The lacrimal gland prolapse recurred in two (4.00%) patients at 29 and 36 months after surgery. Conclusions: Blepharochalasis is rare but mostly occurred in adolescent females. The process from the onset to the stable stage usually lasted for about 7 years, might be associated with the onset of puberty. Surgical management of clinical manifestations after at least 2-year follow-up period of quiescence would be appropriate in order to observe a great plastic effect, low overcorrection and recurrence rate.

show abstract

Section: Discussionmentioning

confidence: 77%

Blepharochalasis:Clinical and Epidemiological Characteristics, Surgical Strategy and Prognosis-- A Retrospective Cohort Study with 93 Cases

Zhou

Ding

2021

Preprint

View full text Add to dashboard Cite

show abstract

“…The loss of elastic fibers in the dermis leading to the reduced elasticity is considered to be a cause of blepharochalasis. Kaneoya et al . reported that elastin mRNA expression in the patient's cultured fibroblasts was not decreased compared with that in control fibroblasts, suggesting that environmental factors or other matrix components of elastic fibers may be involved in the loss of elastic fibers.…”

Section: Discussionmentioning

confidence: 97%

Blepharochalasis: Possibly associated with matrix metalloproteinases

Motegi

Uchiyama

Yamada

et al. 2014

The Journal of Dermatology

View full text Add to dashboard Cite

Blepharochalasis is a rare disorder characterized by recurrent episodic swelling of eyelids, eventually leading to atrophy of skin. Although immunological mechanisms may be involved in the degradation of elastic fibers, the pathogenesis is not well characterized. We report a 10-year-old Japanese boy with an 11-month history of the swelling of bilateral upper eyelids with atrophic skin. Attacks of non-painful swelling in eyelids with erythema have recurred several times a month and lasted for 2-3 days. Histological examination revealed perivascular and interstitial infiltration of lymphocytes in the dermis. Elastica Van Gieson staining showed a marked decrease of elastic fibers throughout the dermis. Results of direct and indirect immunofluorescence analyses were negative. Staining of matrix metalloproteinase (MMP)-3 and MMP-9 was observed in and around infiltrating cells in the dermis, suggesting that MMP-3 and MMP-9 may play, in part, roles in the development of blepharochalasis, and that inhibitor of MMP may have a possibility of therapeutic application.

show abstract

“…Recently, we reported a patient with localized acquired cutis laxa, known as idiopathic lid laxity or as blepharochalasis, which is closely related to primary anetoderma (6). Although elastic fibers had disappeared from the lesional dermis, the dermal fibroblasts from the patient recovered the normal expression level of elastin mRNA after transfer to culture conditions.…”

Section: Discussionmentioning

confidence: 98%

Primary Anetoderma: A Case Report and Its Modified Classification

Ishida

Koizumi

Shinkai

et al. 2005

The Journal of Dermatology

Self Cite

View full text Add to dashboard Cite

A fifty-nine-year-old healthy male presented with fifteen round pouches around his bilateral shoulders and proximal thighs, at which elasticity was lost on palpation. Histopathological examinations demonstrated that the lesional dermis was thinner than normal skin and there was loss of elastic fibers and mild inflammatory cell infiltration. Because there was no preceding inflammatory skin lesion or associated diseases, the patient was diagnosed with primary anetoderma. This is a rare case of primary anetoderma that showed loss of elastic fibers and the thinner dermis. In addition, a modified classification is proposed considering associated diseases with a review of literature.

show abstract

Elastin Gene Expression in Blepharochalasis

Cited by 17 publications

References 9 publications

Blepharochalasis:Clinical and Epidemiological Characteristics, Surgical Strategy and Prognosis-- A Retrospective Cohort Study with 93 Cases

Blepharochalasis:Clinical and Epidemiological Characteristics, Surgical Strategy and Prognosis-- A Retrospective Cohort Study with 93 Cases

Blepharochalasis: Possibly associated with matrix metalloproteinases

Primary Anetoderma: A Case Report and Its Modified Classification

Contact Info

Product

Resources

About