Elastin content of normal and emphysematous lung parenchyma

Chrzanowski, P.; Keller, Stephen; Cerreta, Joseph M.; Mandl, Ines; Turino, Gerard M.

doi:10.1016/0002-9343(80)90004-2

Cited by 89 publications

(48 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Varying degree of disruption and disorientation of elastic fibers was a prominent feature in all most all types of pneumonias ( Figure 10). These findings were in agreement with the earlier reports (Carnes 1968;Chrzanowski et al 1980). Further it has been opined that this disruption of elstin is induced by elastolytic proteinases derived from leukocytes and macrophages.…”

Section: Specific Stainssupporting

confidence: 93%

Histopathological and histoenzymatic studies on bronchopneumonia in sheep

Dar

Darzi

Mir

et al. 2013

Journal of Applied Animal Research

View full text Add to dashboard Cite

To characterize the pneumonic lesions of sheep in Kashmir Valley, India, 257 lungs were collected and processed for routine histopathological examination. Histoenzymatic study was also performed to ascertain the activity of alkaline and acid phosphatases in and around the various lesions. The pneumonic lungs were characterized as acute bronchopneumonia, chronic bronchopneumonia, fibrinous bronchopneumonia, suppurative bronchopneumonia, and interstitial bronchopneumonia. Mast cell hyperplasia and fibroplasia were characteristically observed in chronic lesions while as all the pneumonic lesions were associated with disruption and disorientation of elastin fibers and qualitative increase in acid and neutral mucopolysaccharides.

show abstract

Section: Specific Stainssupporting

confidence: 93%

Histopathological and histoenzymatic studies on bronchopneumonia in sheep

Dar

Darzi

Mir

et al. 2013

Journal of Applied Animal Research

View full text Add to dashboard Cite

show abstract

“…This is followed by a decrease in expression to low levels that persist through adulthood (Kelleher et al, 2004). In adult tissue, elastic fibers are difficult to repair and elastin often does not polymerize or form functional three-dimensional (3D) fibers (Chrzanowski et al, 1980;Shifren and Mecham, 2006). This is probably because the complicated temporal and spatial regulation is difficult to recapitulate in adult tissues.…”

Section: Coordinated Gene Expressionmentioning

confidence: 99%

New insights into elastic fiber assembly

Wagenseil

Mecham

2007

Birth Defects Research Pt C

355

354

View full text Add to dashboard Cite

Elastic fibers provide recoil to tissues that undergo repeated stretch, such as the large arteries and lung. These large extracellular matrix (ECM) structures contain numerous components, and our understanding of elastic fiber assembly is changing as we learn more about the various molecules associated with the assembly process. The main components of elastic fibers are elastin and microfibrils. Elastin makes up the bulk of the mature fiber and is encoded by a single gene. Microfibrils consist mainly of fibrillin, but also contain or associate with proteins such as microfibril associated glycoproteins (MAGPs), fibulins, and EMILIN-1. Microfibrils were thought to facilitate alignment of elastin monomers prior to cross-linking by lysyl oxidase (LOX). We now know that their role, as well as the overall assembly process, is more complex. Elastic fiber formation involves elaborate spatial and temporal regulation of all of the involved proteins and is difficult to recapitulate in adult tissues. This report summarizes the known interactions between elastin and the microfibrillar proteins and their role in elastic fiber assembly based on in vitro studies and evidence from knockout mice. We also propose a model of elastic fiber assembly based on the current data that incorporates interactions between elastin, LOXs, fibulins and the microfibril, as well as the pivotal role played by cells in structuring the final functional fiber. Birth Defects Research (Part C) 81:229-240,

show abstract

“…A reduction in the tensile strength of these tendons was also observed. In the mature human lung, elastin constitutes approximately 30% of the dry tissue weight [9]; elastic elements form a complex, three-dimensional fibrous network, interwoven with collagenous elements, and there is evidence of mechanical connections between the two [65]. In a guinea pig model, the effect of enzymatically removing elastin on the quasi-static mechanical properties of lung parenchymal strips was to cause a large reduction in initial modulus and an increase in extensibility [75].…”

Section: Functionmentioning

confidence: 99%

The elastic fibre network of the human lumbar anulus fibrosus: architecture, mechanical function and potential role in the progression of intervertebral disc degeneration

Smith

Fazzalari

2009

Eur Spine J

View full text Add to dashboard Cite

Elastic fibres are critical constituents of dynamic biological structures that functionally require elasticity and resilience. The network of elastic fibres in the anulus fibrosus of the intervertebral disc is extensive, however until recently, the majority of histological, biochemical and biomechanical studies have focussed on the roles of other extracellular matrix constituents such as collagens and proteoglycans. The resulting lack of detailed descriptions of elastic fibre network architecture and mechanical function has limited understanding of the potentially important contribution made by elastic fibres to healthy disc function and their possible roles in the progression of disc degeneration. In addition, it has made it difficult to postulate what the consequences of elastic fibre related disorders would be for intervertebral disc behaviour, and to develop treatments accordingly. In this paper, we review recent and historical studies which have examined both the structure and the function of the human lumbar anulus fibrosus elastic fibre network, provide a synergistic discussion in an attempt to clarify its potentially critical contribution both to normal intervertebral disc behaviour and the processes relating to its degeneration, and recommend critical areas for future research.

show abstract

Elastin content of normal and emphysematous lung parenchyma

Cited by 89 publications

References 18 publications

Histopathological and histoenzymatic studies on bronchopneumonia in sheep

Histopathological and histoenzymatic studies on bronchopneumonia in sheep

New insights into elastic fiber assembly

The elastic fibre network of the human lumbar anulus fibrosus: architecture, mechanical function and potential role in the progression of intervertebral disc degeneration

Contact Info

Product

Resources

About