Elastin and Collagen in the Fetal Sheep Lung. II. Relationship to Mechanical Properties of the Lung

Jc, Schellenberg; Gc, Liggins; Ja, Kitterman; Cc, Lee

doi:10.1203/00006450-198709000-00020

Cited by 28 publications

(14 citation statements)

References 11 publications

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“…Additional factors, other than surfactant, may influence neonatal lung stability. These include alveolar capillary permeability (34), composition and microstructure of alveolar surfactant (35) or the connective tissue of the lung (36)(37)(38). In our study, inosito1-k glucocorticoid increased lavageable surfactant in the fetus.…”

Section: Resultsmentioning

confidence: 50%

Inositol and Glucocorticoid in the Development of Lung Stability in Male and Female Rabbit Fetuses

et al. 1988

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ABSTRACT. Inasmuch as inositol affects the development of lung surfactant, and exogenous glucocorticoids accelerate fetal lung maturation, a possible interaction of the two substances on alveolar stability of preterm rabbit fetuses of 28 days gestation was investigated. On days 26 and 27 of gestation inositol or glucose were added to the diet of does treated with betamethasone (0.2 mg/kg intramuscularly on days 26 and 27). Inositol increased lung-thorax compliance of paralyzed fetuses at all insufflation pressures studied (from 16 to 22.5 and 30 cm HzO and back to 22.5, and 16 cm HzO). At a ventilation pressure of 30 cm HzO, lung-thorax compliance of fetuses treated with inosit01 plus betamethasone was more than doubled as compared with controls (1.2 2 0.6 versus 0.5 f 0.2 ml/kg X cm HzO,p < 0.001). Inositol alone had no detectable effect on compliance, whereas betamethasone tended to increase compliance (p = 0.05). According to variance analysis, the effect of inositol was statistically significant only among the males. Inositol prevented the glucocorticoid-induced decrease in lung protein and, to a lesser extent, the decrease in DNA. Inositol did not further increase the lavageable surfactant pool of the glucocorticoid-treated, ventilated fetuses, although the area occupied by lamellar bodies within type I1 cells was increased after inositol plus betamethasone. According to the present study, inositol modifies the physiologic and biochemical response of the immature fetal lung to a pharmacologic dose of exogenous glucocorticoid. (Pediatr Res 24: 617-621, 1988) Abbreviations BM, betamethasone BW, body weight RDS, respiratory distress syndromeThe physiologic role of glucocorticoids in fetal lung maturation is widely acknowledged (1, 2). Exogenous glucocorticoids accel-

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Section: Resultsmentioning

confidence: 50%

Inositol and Glucocorticoid in the Development of Lung Stability in Male and Female Rabbit Fetuses

et al. 1988

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“…An adequate quantity of elastin is required for normal lung compliance. 8 Our data show reduced expression and disorganized deposition of elastin in the nitrofen rat model of CDH. Total desmosine content was decreased significantly in CDH lungs compared with controls.…”

Section: Discussionmentioning

confidence: 79%

“…Elastin expression is a critical component of the EM involved in pulmonary development 7 and proper lung mechanics. 8 Previous studies of elastin expression in CDH lungs have yielded mixed results. [9][10][11][12] To investigate the expression of elastin, we chose the nitrofen-induced CDH rat model, in which the diaphragmatic defect occurs during the embryonic stage of lung development.…”

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confidence: 97%

Pulmonary elastin expression is decreased in the nitrofen-induced rat model of congenital diaphragmatic hernia

Mychaliska

Officer

Heintz

et al. 2004

Journal of Pediatric Surgery

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“…This suggests that -there is synergism on alveolar surfactant production between cortisol and triiodothyronine and between cortisol and adrenaline, -there is synergism between cortisol, triiodothyronine and prolactin in increasing distensibility of the lung, and -distensibility of the lung does not depend on surfactant levels alone. Elastin and collagen concentration were higher in lungs that were distensible and stable after hormone infusion than in non-distensible and unstable lungs, suggesting that changes in connective tissue are associated with changes in the mechanical properties of the fetal lung [42].…”

Section: Experiments In Fetal Sheepmentioning

confidence: 94%

New approaches to hormonal acceleration of fetal lung maturation

Schellenberg¹,

Liggins²

1987

Journal of Perinatal Medicine

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The paper reviews the effects on lung maturation of glucocorticoids in animals and humans and presents relevant recent findings from the author's laboratory. It is now well established that antenatal glucocorticoid treatment reduces the incidence and severity of the respiratory distress syndrome (RDS) in prematurely born infants. The recommended doses of glucocorticoids produce fetal glucocorticoid activity levels similar to those of newborns with RDS or prolonged rupture of the membranes. Extensive follow-up studies have shown that adverse effects on child development are unlikely to occur. It is also evident that a significant number of fetuses do not respond to the treatment, which is of particular consequence in fetuses of less than 28 weeks gestation. These fetuses are less likely to respond to glucocorticoid therapy that fetuses between 28 and 32 weeks gestation and are at a higher risk of developing complications due to their immaturity. In fetal sheep, there is a similar decrease in the efficacy of glucocorticoids on lung maturation with decreasing gestational age. Simultaneous infusion of cortisol, triiodothyronine and prolactin but not of any of these hormones administered singly or in combination of two produced mature lungs in fetal sheep of 125 days gestation. Similar results were obtained with thyrotropin releasing hormone (TRH) and cortisol. It remains to be seen whether the combined administration of glucocorticoids and TRH accelerates lung maturation in human fetuses.

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Elastin and Collagen in the Fetal Sheep Lung. II. Relationship to Mechanical Properties of the Lung

Cited by 28 publications

References 11 publications

Inositol and Glucocorticoid in the Development of Lung Stability in Male and Female Rabbit Fetuses

Inositol and Glucocorticoid in the Development of Lung Stability in Male and Female Rabbit Fetuses

Pulmonary elastin expression is decreased in the nitrofen-induced rat model of congenital diaphragmatic hernia

New approaches to hormonal acceleration of fetal lung maturation

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