Elasticity imaging of atheroma with transcutaneous ultrasound both in longitudinal-axis and short-axis planes

Kanai, Hiroshi; Hasegawa, Hideyuki; Nakagawa, N.

doi:10.1016/j.ics.2004.07.029

Cited by 2 publications

(2 citation statements)

References 24 publications

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“…Texture analysis of strain rate images of plaque tissue has indicated that increased local variations in strain rate in plaques may help identify vulnerable plaques [36]. Moreover, earlier work on arterial elastography by Kanai et al [37] showed increased spatial heterogeneity of the elasticity around plaques, where large stress is concentrated. Finally, previous work by our group has shown that PWI was able to detect increased nonlinearity in the pulse wave propagation in AAAs [28], [38] with unstable aneurysms appearing to be the most inhomogeneous [29].…”

Section: Introductionmentioning

confidence: 99%

Adaptive Pulse Wave Imaging: Automated Spatial Vessel Wall Inhomogeneity Detection in Phantoms and in-Vivo

Apostolakis

Karageorgos

Nauleau

et al. 2020

IEEE Trans. Med. Imaging

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Imaging arterial mechanical properties may improve vascular disease diagnosis. Pulse wave velocity (PWV) is a marker of arterial stiffness linked to cardiovascular mortality. Pulse wave imaging (PWI) is a technique for imaging the pulse wave propagation at high spatial and temporal resolution. In this study, we introduce adaptive PWI, a technique for the automated partition of heterogeneous arteries into individual segments characterized by most homogeneous pulse wave propagation, allowing for more robust PWV estimation. This technique was validated in a silicone phantom with a soft-stiff interface. The mean detection error of the interface was 4.67±0.73 mm and 3.64±0.14 mm in the stiff-to-soft and soft-to-stiff pulse wave transmission direction, respectively. This technique was tested in monitoring the progression of atherosclerosis in mouse aortas in vivo (n = 11). PWV was found to already increase at the early stage of 10 weeks of highfat diet (3.17±0.67m/sec compared to baseline 2.55±0.47m/sec, p < 0.05) and further increase after 20 weeks of high-fat diet (3.76±1.20m/sec). The number of detected segments of the imaged aortas monotonically increased with the duration of high-fat diet indicating an increase in arterial wall property inhomogeneity. The performance of adaptive PWI was also tested in aneurysmal mouse aortas in vivo. Aneurysmal boundaries were detected with a mean error of 0.68±0.44mm. Finally, initial feasibility was shown in the carotid arteries of healthy and atherosclerotic human subjects in vivo (n = 3 each). Consequently, adaptive PWI was successful in detecting stiffness inhomogeneity at its early onset and monitoring atherosclerosis progression in vivo.

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Section: Introductionmentioning

confidence: 99%

Adaptive Pulse Wave Imaging: Automated Spatial Vessel Wall Inhomogeneity Detection in Phantoms and in-Vivo

Apostolakis

Karageorgos

Nauleau

et al. 2020

IEEE Trans. Med. Imaging

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“…Although there are techniques for evaluating the intimamedia thickness 3,4) and elasticity of an arterial wall [5][6][7] for the diagnosis of atherosclerosis, flow-mediated dilation (FMD) measurements in brachial and other conduit arteries have become popular means of evaluating the endothelial function for the early diagnosis of atherosclerosis. 8,9) Endothelial cells, which release nitric oxide (NO) in response to shear stress from blood flow, 10) have a function of relaxing smooth muscle in the media of the arterial wall.…”

Section: Introductionmentioning

confidence: 99%

Ultrasonic Measurement of Change in Elasticity due to Endothelium Dependent Relaxation Response by Accurate Detection of Artery-Wall Boundary

Kaneko

Hasegawa

Kanai

2007

jjap

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Ross hypothesized that an endothelial dysfunction is considered to be an initial step in atherosclerosis. Endothelial cells, which release nitric oxide (NO) in response to shear stress from blood flow, have a function of relaxing smooth muscle in the media of the arterial wall. For the assessment of the endothelial function, there is a conventional method in which the change in the diameter of the brachial artery caused by flow-mediated dilation (FMD) is measured with ultrasound. However, despite the fact that the collagen-rich hard adventitia does not respond to NO, the conventional method measures the change in diameter depending on the mechanical property of the entire wall including the adventitia. Therefore, we developed a method of measuring the change in the thickness and the elasticity of the brachial artery during a cardiac cycle using the phased tracking method for the evaluation of the mechanical property of only the intima-media region. In this study, the initial positions of echoes from the lumen-intima and media-adventitia boundaries are determined using complex template matching to accurately estimate the minute change in the thickness and the elasticity of the brachial and radial arteries. The ambiguity in the determination of such boundaries was eliminated using complex template matching, and the change in elasticity measured by the proposed method was larger than the change in inner diameter obtained by the conventional method.

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Elasticity imaging of atheroma with transcutaneous ultrasound both in longitudinal-axis and short-axis planes

Cited by 2 publications

References 24 publications

Adaptive Pulse Wave Imaging: Automated Spatial Vessel Wall Inhomogeneity Detection in Phantoms and in-Vivo

Adaptive Pulse Wave Imaging: Automated Spatial Vessel Wall Inhomogeneity Detection in Phantoms and in-Vivo

Ultrasonic Measurement of Change in Elasticity due to Endothelium Dependent Relaxation Response by Accurate Detection of Artery-Wall Boundary

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