Elastic scattering spectroscopy for the diagnosis of colonic lesions: initial results of a novel optical biopsy technique

Dhar, Anjan; Johnson, Kristie; Novelli, Marco; Bown, Stephen G.; Bigio, Irving J.; Lovat, Laurence; Bloom, Stuart

doi:10.1016/j.gie.2005.07.026

Cited by 102 publications

(80 citation statements)

References 23 publications

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“…More advanced fibre optic probes for PLSS made use of gradient-index (GRIN) lens to implement depth selective measurement from a range of near surface depths (100-200 mm) to interrogate blood supply [66,67]. A great number of translational studies for diagnosis of breast cancer [68], prostate cancer [69], intraoperative determination of sentinel lymph node status in the breast [70], colonic lesions [71], oral premalignancy [72], high grade dysplasia and cancer in Barrett's oesophagus [73,74], cervix neoplasia [75,76], investigation of the nature of aceto-whitening in cervix cancer inspection [77][78][79][80][81][82], gold nanoparticle sizing [83], and monitoring apoptosis in cell cultures [84][85][86] have demonstrated that LSS provides a promising solution for cell culture monitoring, tissue surveillance and biopsy guidance in a relatively simple and cost effective configuration.…”

Section: Polarized Light and Biological Tissuementioning

confidence: 99%

Mueller polarimetric imaging for surgical and diagnostic applications: a review

2017

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Polarization is a fundamental property of light and a powerful sensing tool that has been applied to many areas. A Mueller matrix is a complete mathematical description of the polarization characteristics of objects that interact with light, and is known as a transfer function of Stokes vectors which characterise the state of polarization of light. Mueller polarimetric imaging measures Mueller matrices over a field of view and thus allows for visualising the polarization characteristics of the objects. It has emerged as a promising technique in recent years for tissue imaging, improving image contrast and providing a unique perspective to reveal additional information that cannot be resolved by other optical imaging modalities. This review introduces the basis of the Stokes-Mueller formulism, interpretation methods of Mueller matrices into fundamental polarization properties, polarization properties of biological tissues, and considerations in the construction of Mueller polarimetric imaging devices for surgical and diagnostic applications, including primary configurations, optimization procedures, calibration methods as well as the instrument polarization properties of several widelyused biomedical optical devices. The paper also reviews recent progress in Mueller polarimetric endoscopes and fibre Mueller polarimeters, followed by the future outlook in applying the technique to surgery and diagnostics. Tissue polarization properties convey morphological, micro-structural and compositional information of tissue with great potential for label free characterization of tissue pathological changes. Recent progress in tissue polarimetric imaging and polarization resolved endoscopy paved the way for translation of polarimetric imaging to surgery and tissue diagnosis.

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Section: Polarized Light and Biological Tissuementioning

confidence: 99%

Mueller polarimetric imaging for surgical and diagnostic applications: a review

2017

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“…Three common spectroscopic techniques are Raman spectroscopy (RS), diffuse reflectance spectroscopy (DRS), and laser-induced fluorescence spectroscopy (LIFS). These techniques have been applied -either individually or in combinations -throughout the entire human body to investigate a wide range of pathologies including: atherosclerosis, 1, 2 osteoporosis, 3 brain edema, 4 cataract formation, 5 kidney stones, 6,7 and diabetes 8 and cancer of the breast, 9-11 cervix, 12 esophagus, 13,14 gastrointestinal tract, 15,16 brain, 17 lungs, 18,19 ovaries, 20 and bladder. 21 Here, we present a novel multimodal spectroscopy (MMS) device, combining RS, LIFS, and DRS, for the purpose of fast and non-invasive early detection of skin cancer which uses a variety of instrumentation and a custom contact probe capable of delivering and collecting light for all three modalities.…”

Section: Introductionmentioning

confidence: 99%

Design and characterization of a novel multimodal fiber-optic probe and spectroscopy system for skin cancer applications

Sharma

Marple²,

Reichenberg

et al. 2014

Review of Scientific Instruments

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The design and characterization of an instrument combining Raman, fluorescence, and reflectance spectroscopic modalities is presented. Instrument development has targeted skin cancer applications as a novel fiber-optic probe has been specially designed to interrogate cutaneous lesions. The instrument is modular and both its software and hardware components are described in depth. Characterization of the fiber-optic probe is also presented, which details the probe's ability to measure diagnostically important parameters such as intrinsic fluorescence and absorption and reduced scattering coefficients along with critical performance metrics such as high Raman signal-to-noise ratios at clinically practical exposure times. Validation results using liquid phantoms show that the probe and system can extract absorption and scattering coefficients with less than 10% error. As the goal is to use the instrument for the clinical early detection of skin cancer, preliminary clinical data are also presented, which indicates our system's ability to measure physiological quantities such as relative collagen and nicotinamide adenine dinucleotide concentration, oxygen saturation, blood volume fraction, and mean vessel diameter.

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“…To obtain this information, optical techniques can take advantage of the very distinct absorption features of oxygenated (oxy-) and deoxygenated (deoxy-) hemoglobin (Hb), and have the ability to provide noninvasive, in-vivo monitoring. However, current optical techniques for this purpose, including pulse oximetry, elastic light spectroscopy [2], diffuse reflectance spectroscopy [3], and differential path length spectroscopy [4], suffer from poor spatial resolution, thus only obtaining tissue properties averaged over large volumes. These methods are also unable to obtain precise information regarding the trajectories of the measured photons; as a result, parameters of interest, including absorption, are estimated by employing empirical and/or Monte Carlo simulations rather than physical models.…”

Section: Introductionmentioning

confidence: 99%

Assessing hemoglobin concentration using spectroscopic optical coherence tomography for feasibility of tissue diagnostics

Robles¹,

Chowdhury²,

Wax³

2010

Biomed. Opt. Express

119

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Hemoglobin (Hb) concentration and oxygen saturation levels are important biomarkers for various diseases, including cancer. Here, we investigate the ability to measure these parameters for tissue using spectroscopic optical coherence tomography (SOCT). A parallel frequency domain OCT system is used with detection spanning the visible region of the spectrum (450 nm to 700 nm). Oxygenated and deoxygenated Hb absorbing phantoms are analyzed. The results show that Hb concentrations as low as 1.2 g/L at 1 mm can be retrieved indicating that both normal and cancerous tissue measurements may be obtained. However, measurement of oxygen saturation levels may not be achieved with this approach.

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Elastic scattering spectroscopy for the diagnosis of colonic lesions: initial results of a novel optical biopsy technique

Cited by 102 publications

References 23 publications

Mueller polarimetric imaging for surgical and diagnostic applications: a review

Mueller polarimetric imaging for surgical and diagnostic applications: a review

Design and characterization of a novel multimodal fiber-optic probe and spectroscopy system for skin cancer applications

Assessing hemoglobin concentration using spectroscopic optical coherence tomography for feasibility of tissue diagnostics

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