Elastic proteins and elastomeric protein alloys

Aghaei-Ghareh-Bolagh, Behnaz; Mithieux, Suzanne M.; Weiss, Anthony S.

doi:10.1016/j.copbio.2015.12.020

Cited by 30 publications

(20 citation statements)

References 57 publications

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“…Variable region-specific cross-linking degree in Resilin matrices may inspire the analysis of cross-linking degree of tropoelastins in elastin matrices [ 43 ]. Indeed, covalent bonds between tropoelastins via lysinonorleucine, allysine aldol and desmosine are random [ 44 ] and, therefore, like in Resilin, may depend on the activity of cross-linking enzymes that in turn may be under tissue-specific control to adjust elastin elasticity to the needs.…”

Section: Discussionmentioning

confidence: 99%

Resilin matrix distribution, variability and function in Drosophila

et al. 2020

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Background Elasticity prevents fatigue of tissues that are extensively and repeatedly deformed. Resilin is a resilient and elastic extracellular protein matrix in joints and hinges of insects. For its mechanical properties, Resilin is extensively analysed and applied in biomaterial and biomedical sciences. However, there is only indirect evidence for Resilin distribution and function in an insect. Commonly, the presence of dityrosines that covalently link Resilin protein monomers (Pro-Resilin), which are responsible for its mechanical properties and fluoresce upon UV excitation, has been considered to reflect Resilin incidence. Results Using a GFP-tagged Resilin version, we directly identify Resilin in pliable regions of the Drosophila body, some of which were not described before. Interestingly, the amounts of dityrosines are not proportional to the amounts of Resilin in different areas of the fly body, arguing that the mechanical properties of Resilin matrices vary according to their need. For a functional analysis of Resilin matrices, applying the RNA interference and Crispr/Cas9 techniques, we generated flies with reduced or eliminated Resilin function, respectively. We find that these flies are flightless but capable of locomotion and viable suggesting that other proteins may partially compensate for Resilin function. Indeed, localizations of the potentially elastic protein Cpr56F and Resilin occasionally coincide. Conclusions Thus, Resilin-matrices are composite in the way that varying amounts of different elastic proteins and dityrosinylation define material properties. Understanding the biology of Resilin will have an impact on Resilin-based biomaterial and biomedical sciences.

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Section: Discussionmentioning

confidence: 99%

Resilin matrix distribution, variability and function in Drosophila

et al. 2020

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“…Collagen structure is mostly dominated by rigid secondary regions of triple-helix, thus resulting in 29 types of collagen. Collagen is flexible macromolecule, with strain at break of 10-20% and a resilience of 90% [41]. Elasticity of collagen may differ depending from the structural arrangement of fibrous tracts.…”

Section: Table 1 Mechanical Properties Of Proteinsmentioning

confidence: 99%

“…Elastin is widely used in soft tissue engineering e.g. split-skin autografts for burn wounds, gastrointestinal patches, heart valve replacement and vascular grafts [41]. However, natural elastin is not used often in cardiovascular prosthetic implants due to its purification, batch-tobatch variations, and high propensity to calcification due to its poorly defined purification [47].…”

Section: Table 1 Mechanical Properties Of Proteinsmentioning

confidence: 99%

Bio-Inspired Polymer-Polymer Hybrids for Medical Applications

Demirci¹,

Niedźwiedź²,

Kantor-Malujdy³

et al. 2021

Preprint

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Novel bio-inspired materials have gained recently great attention, especially in medical applications. Applying sophisticated design and engineering methods, various polymer-polymer hybrid systems with outstanding performance have been developed in last decades. Hybrid systems composed of bioelastomers and hydrogels are very attractive due to their high biocompatibility and elastic nature for advanced biomaterials used in various medical applications such as drug delivery systems and scaffolds for tissue engineering. Herein, we describe the advances in current state-of-the-art design, properties and applications of polymer-polymer hybrid systems in medical applications. Bio-inspired functionalities, including bioadhesiveness, injectability, antibacterial properties and degradability applicable to advanced drug delivery systems and medical devices will be discussed in a context of future efforts towards development of bioinspired materials.

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“…Up to now, studies on the extraction, isolation and valorization of isolated amino acids in the manufacture of protein-based biomaterials have been widely reported in the literature [15][16][17][18]. In this context, glutamic acid is a fi ve-carbon amino acid present in wheat DDG and has shown high potential as a building block for polymerization.…”

Section: Crop Plant By-products From Industrial Processingmentioning

confidence: 99%

Valorization of Agricultural Wastes for the Production of Protein-Based Biopolymers

Burgos¹,

Valdés²,

Jiménez³

2016

j renew mater

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In this study we provide an overview of the latest developments on the extraction, production, modifi cation and applications of fruit residues and by-products in the formation of protein-based biopolymers, in particular for the formulation of edible fi lms. Our aim was mainly to demonstrate the highly transdisciplinary character of these topics by giving an overview of the main developments and research topics in the chemistry and engineering aspects of protein-based biopolymers. These innovative raw materials have been evaluated for the production of biomaterials to be used in some key sectors, such as food packaging.

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Elastic proteins and elastomeric protein alloys

Cited by 30 publications

References 57 publications

Resilin matrix distribution, variability and function in Drosophila

Resilin matrix distribution, variability and function in Drosophila

Bio-Inspired Polymer-Polymer Hybrids for Medical Applications

Valorization of Agricultural Wastes for the Production of Protein-Based Biopolymers

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