Elastic polyurethane bearing pendant TGF-β1 affinity peptide for potential tissue engineering applications

Wu, Gang; Xiao, Meng; Xiao, Jiangwei; Guo, Lin; Ke, Yu; Li, Hong; Fang, Liming; Deng, Chunlin; Liao, Hua

doi:10.1016/j.msec.2017.10.006

Cited by 14 publications

(7 citation statements)

References 50 publications

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“…The various of techniques have been applied to fabricate the TPU scaffolds including phase separation, solvent casting, electrospinning and coprecipitation method, and so forth. Similar to other typical scaffolds, many factors have an effect on the application of TPU and TPU‐based scaffolds, such as the surface chemical properties, surface morphology and structure, porosity, biological activity, and so forth . The nanofibers have attracted increasing attention in recent years due to their large specific surface area, high porosity, excellent interconnectivity, more contact sites for cells and similar structure with the natural extracellular matrix.…”

Section: Introductionmentioning

confidence: 99%

Modification of thermoplastic polyurethane nanofiber membranes by in situ polydopamine coating for tissue engineering

Lin

Wang

Cheng

et al. 2020

J of Applied Polymer Sci

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To improve the interaction between cells and scaffolds, the appropriate surface chemical property is very important for tissue engineering scaffolds. In this work, the dopamine (DA) was first introduced into thermoplastic polyurethane (TPU) matrix to obtain TPU/DA nanofibers by electrospinning. Subsequently, the TPU@polydopamine (PDA) composite nanofibers with core/shell structure were fabricated by in situ polymerization of PDA. In comparison with TPU nanofibers, the uniformization of PDA coating layer on the surface of TPU/DA composite nanofibers significantly increased due to the addition of DA, which used as the active sites to guide the PDA particles accumulated along with the fiber direction. The hydrophilicity and water uptake ability of TPU@PDA composite nanofibers were larger than those of TPU nanofibers. The TPU@PDA composite nanofibers possess excellent comprehensive mechanical properties of high strength, stiffness, elasticity, and recoverability because of the hydrogen bonding occurrence between PDA and DA, as well as between PDA and TPU matrix. The attachment and viability of mouse embryonic osteoblasts cells (MC3T3‐E1) cultured on TPU@PDA composite nanofibers were obviously enhanced compared with TPU nanofibers. Those results suggested that the modified TPU@PDA composite nanofibers have superior mechanical and biological properties, which promoting them potentially useful for tissue engineering scaffolds.

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Section: Introductionmentioning

confidence: 99%

Modification of thermoplastic polyurethane nanofiber membranes by in situ polydopamine coating for tissue engineering

Lin

Wang

Cheng

et al. 2020

J of Applied Polymer Sci

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“…[13][14][15][16] Numerous laboratories prepared bioactive modication of biodegradable polyurethane which pendent alkynyl on hard segment and azide-ended peptide were linked to form a 1,2,3-triazole with covalent bonding by click reaction. [17][18][19][20] Taking into account the surface self-enrichment of sosegments of PUs as a result of their higher mobility than hard-segments, polyurethane with pendant azide groups on the so segment (PU-GAP) was prepared rstly in this study to further increase the content of azide groups and improve their surface enrichment. [21][22][23] The azide groups on the so segment afford more reactive agents interacting with antifouling molecules, comparing with the selective modication by the functional groups of the end groups of the polyurethane.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of polyurethanes with pendant azide groups attached on the soft segments and the surface modification with mPEG by click chemistry for antifouling applications

et al. 2018

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“…This led to a reduction in necrosis and a faster regenerative response, contrasting with unmodified PU fragments, around which no formation of new muscle fibers could be observed. [ 147 ] The same peptide was tested with porous chitosan scaffolds for enhancing cartilage regeneration. [ 148 ] Upregulation of chondrogenic‐related genes such as Sox9, Col II, and AGG in cultured MSC was positively correlated with the amount of TGF‐β1‐binding peptide.…”

Section: Solid‐phase Presentationmentioning

confidence: 99%

Biomaterials for Sequestration of Growth Factors and Modulation of Cell Behavior

Teixeira

Domingues

Shevchuk

et al. 2020

Adv Funct Materials

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Growth factors (GFs) are proteins secreted by cells that regulate a variety of biological processes. Although they have long been proposed as potent therapeutic agents, their administration in a soluble form has proven costly and ineffective due to their short half-lives in biological environments. Biomaterial-based approaches are increasingly sought as alternatives to improve the efficacy or, ideally, replace the need for exogenous administration of GFs in regenerative medicine strategies. The means by which these systems evolve from biomaterials for conventional controlled release of GFs to the recent extracellular matrix (ECM)-inspired approaches for sequestering these labile molecules and regulating their spatiotemporal activity and presentation are reviewed. Focus is placed on biomaterials functionalized either with ECM components, which show promiscuous GF binding, or with targeted GF ligands (antibodies, aptamers, or peptides). The potential of synthetic platforms with abiotic affinity as cost-effective alternatives to the current biological ligands is also discussed. Overall, the various GF sequestering systems developed so far have remarkably improved the activity of GFs at reduced doses and, in some cases, completely avoided the need for their exogenous administration to guide cell fates. These bioinspired concepts thus enable the rational exploration of the full therapeutic potential of GFs in regenerative medicine.

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Elastic polyurethane bearing pendant TGF-β1 affinity peptide for potential tissue engineering applications

Cited by 14 publications

References 50 publications

Modification of thermoplastic polyurethane nanofiber membranes by in situ polydopamine coating for tissue engineering

Modification of thermoplastic polyurethane nanofiber membranes by in situ polydopamine coating for tissue engineering

Synthesis of polyurethanes with pendant azide groups attached on the soft segments and the surface modification with mPEG by click chemistry for antifouling applications

Biomaterials for Sequestration of Growth Factors and Modulation of Cell Behavior

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