Elastic modulus and in vitro biocompatibility of Ti−xNb and Ti−xTa alloys

Kim, Seung Eon; Jeong, Hwan Jeong; Hyun, Yong-Taek; Lee, Yong Tai; Jung, Chan Hoi; Kim, Soon Kook; Song, Jae–Sung; Lee, Jun Hee

doi:10.1007/bf03027565

Cited by 25 publications

(6 citation statements)

References 10 publications

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“…A 3 mL aliquot of Dulbecco's modified eagle medium (enhanced with 2.5 µg/mL amphotericin B, 50 µg/mL gentamicin, and 10% fetal bovine serum) was poured into each well. Cultures were incubated at 37 • C under a 5% CO 2 environment [22]. The incubation medium was replaced every 48 h for the duration of the experiment.…”

Section: In Vitro Characterizationmentioning

confidence: 99%

In Vitro and Electrochemical Characterization of Laser-Cladded Ti-Nb-Ta Alloy for Biomedical Applications

et al. 2022

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Titanium (Ti) and its alloys are predominant choices for use as biomaterials in human implants. Research has shown the adverse effects of using commercial Ti alloy Ti-6Al-4V in the human body, and this presents a need for viable alternatives. In this study, Ti alloy Ti-17Nb-6Ta was manufactured by laser cladding—a prominent additive manufacturing (AM) technology. Laser cladded specimens were evaluated for their in vitro and electrochemical behavior. A human osteosarcoma cell line (MG-63 cells) was used for in vitro investigations. Cell proliferation was good in the physiological medium, and cells were alive when in contact with the laser cladded alloy, even after two to three weeks, indicating good cell viability and compatibility with this alloy. Electrochemical characterization was carried out in Ringer’s solution, and noticeably lower corrosion current density and corrosion rate values were observed. The lower amounts of these parameters indicated the passivation behavior due to multi-layer Ti, Nb, and Ta alloy oxide films. These oxide films also enhanced osseointegration. Thus, the Ti-17Nb-6Ta alloy can be an ideal biocompatible alternative to Ti-6Al-4V.

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Section: In Vitro Characterizationmentioning

confidence: 99%

In Vitro and Electrochemical Characterization of Laser-Cladded Ti-Nb-Ta Alloy for Biomedical Applications

et al. 2022

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“…The elastic modulus of these materials decreases to ~80 GPa at ~25 wt.% of Nb for TiNb, to ~50 GPa at ~25 wt.% of Nb and 6.25% Zr for TiNbZr, and to ~75 GPa at ~23 wt.% of Ta and 10 wt.% of Zr for TiTaZr [9,10]. At the same time, these alloys in general have a higher corrosion resistance [11]. Moreover, these alloys can overcome another problem associated with the Ti6Al4V-based implants, namely the potential release of harmful elements V and Al, which can induce, among others, high levels of prostaglandin E2 that plays an important role in regulation of the bone resorption process [12,13].…”

Section: Introductionmentioning

confidence: 99%

Beta-Titanium Alloy Covered by Ferroelectric Coating–Physicochemical Properties and Human Osteoblast-Like Cell Response

et al. 2021

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Beta-titanium alloys are promising materials for bone implants due to their advantageous mechanical properties. For enhancing the interaction of bone cells with this perspective material, we developed a ferroelectric barium titanate (BaTiO3) coating on a Ti39Nb alloy by hydrothermal synthesis. This coating was analyzed by scanning electron and Raman microscopy, X-ray diffraction, piezoresponse force microscopy, X-ray photoelectron spectroscopy, nanoindentation, and roughness measurement. Leaching experiments in a saline solution revealed that Ba is released from the coating. A progressive decrease of Ba concentration in the material was also found after 1, 3, and 7 days of cultivation of human osteoblast-like Saos-2 cells. On day 1, the Saos-2 cells adhered on the BaTiO3 film in higher initial numbers than on the bare alloy, but they were less spread, and their initial proliferation rate was slower. These cells also contained a lower amount of beta1-integrins and vinculin, i.e., molecules involved in cell adhesion, and produced a lower amount of collagen I. This cell behavior was attributed to a higher surface roughness of BaTiO3 film rather than to its potential cytotoxicity, because the cell viability on this film was very high, reaching almost 99%. The amount of alkaline phosphatase, an enzyme involved in bone matrix mineralization, was similar in cells on the BaTiO3-coated and uncoated alloy, and on day 7, the cells on BaTiO3 film attained a higher final cell population density. These results indicate that after some improvements, particularly in its roughness and stability, the hydrothermal ferroelectric BaTiO3 film could be promising coating for improved osseointegration of bone implants.

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“…This is accomplished by alloying Ti with sufficient quantities of β-stabilizing elements (e.g., Nb or Ta) to suppress the formation of other phases [6]. To date, many low modulus β-type Ti alloys have been developed for biomedical applications, such as Ti-Nb [7,8], Ti-Ta [8,9], Ti-Nb-Zr [10][11][12][13][14][15], Ti-Ta-Zr [16,17], Ti-Nb-Hf [18,19], Ti-Nb-Ta-Zr [20][21][22][23][24], Ti-Nb-Sn [25][26][27], Ti-Nb-Zr-Sn [28,29], etc.…”

Section: Introductionmentioning

confidence: 99%

In-Situ Laser Directed Energy Deposition of Biomedical Ti-Nb and Ti-Zr-Nb Alloys from Elemental Powders

González

Contreras

Punset

et al. 2021

Metals

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In order to achieve the required properties of titanium implants, more resources and research are needed to turn into reality the dream of developing the perfect implant material. The objective of this study was to evaluate the viability of the Laser Directed Energy Deposition to produce biomedical Ti-Nb and Ti-Zr-Nb alloys from elemental powders (Ti, Nb and Zr). The Laser Directed Energy Deposition is an additive manufacturing process used to build a component by delivering energy and material simultaneously. The material is supplied in the form of particles or wire and a laser beam is employed to melt material that is selectively deposited on a specified surface, where it solidifies. Samples with different compositions are characterized to analyze their morphology, microstructure, constituent phases, mechanical properties, corrosion resistance and cytocompatibility. Laser-deposited Ti-Nb and Ti-Zr-Nb alloys show no relevant defects, such as pores or cracks. Titanium alloys with lower elastic modulus and a significantly higher hardness than Ti grade 2 were generated, therefore a better wear resistance could be expected from them. Moreover, their corrosion resistance is excellent due to the formation of a stable passive protective oxide film on the surface of the material; in addition, they also possess outstanding cytocompatibility.

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Elastic modulus and in vitro biocompatibility of Ti−xNb and Ti−xTa alloys

Cited by 25 publications

References 10 publications

In Vitro and Electrochemical Characterization of Laser-Cladded Ti-Nb-Ta Alloy for Biomedical Applications

In Vitro and Electrochemical Characterization of Laser-Cladded Ti-Nb-Ta Alloy for Biomedical Applications

Beta-Titanium Alloy Covered by Ferroelectric Coating–Physicochemical Properties and Human Osteoblast-Like Cell Response

In-Situ Laser Directed Energy Deposition of Biomedical Ti-Nb and Ti-Zr-Nb Alloys from Elemental Powders

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