Elastic materials for tissue engineering applications: Natural, synthetic, and hybrid polymers

Coenen, Anna M.J.; Bernaerts, Katrien V.; Harings, Jules; Jockenhoevel, Stefan; Ghazanfari, Samaneh

doi:10.1016/j.actbio.2018.08.027

Cited by 124 publications

(69 citation statements)

References 194 publications

(262 reference statements)

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“…31,32 In this study, we evaluated the feasibility of using decellularized tendon-derived scaffolds for vascular regeneration applications. Since elasticity is essential for these applications, 33 the scaffolds were crosslinked with the bovine elastin to add an elastic component to the constructs.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of an elastic decellularized tendon‐derived scaffold for the vascular tissue engineering application

Ghazanfari

Alberti

et al. 2019

J Biomedical Materials Res

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Due to the limited success rate of currently available vascular replacements, tissue engineering has received tremendous attention in recent years. A main challenge in the field of regenerative medicine is creating a mechanically functional tissue with a well‐organized extracellular matrix, particularly of collagen and elastin. In this study, the native collagen scaffold derived from decellularized tendon sections, as a scaffold having the potential to be used for vascular tissue engineering applications, was studied. We showed that the elasticity of the scaffolds was improved when crosslinked with the bovine elastin. The effect of different concentrations of elastin on mechanical properties of the collagen scaffolds was evaluated of which 15% elastin concentration was selected for further analysis based on the results. Addition of 15% elastin to collagen scaffolds significantly decreased Young's modulus and the tensile stress at the maximum load and increased the tensile strain at the maximum load of the constructs as compared to those of the collagen scaffolds or control samples. Moreover, tubular elastin modified collagen scaffolds showed significantly higher burst pressure compared to the control samples. Smooth muscle cells and endothelial cells cultured on the elastin modified collagen scaffolds showed high viability (>80%) after 1, 3, and 7 days. Furthermore, the cells showed a high tendency to align with the collagen fibers within the scaffold and produced their own extracellular matrix over time. In conclusion, the results show that the decellularized tendon sections have a great potential to be used as scaffolds for vascular tissue engineering applications. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 1225–1234, 2019.

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Section: Discussionmentioning

confidence: 99%

Evaluation of an elastic decellularized tendon‐derived scaffold for the vascular tissue engineering application

Ghazanfari

Alberti

et al. 2019

J Biomedical Materials Res

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“…While synthetic polymers are often crucial to control degradation and mechanical properties, a material completely derived from natural materials may be ideal for mimicking the native cell microenvironment. 33 In this work, we developed a novel method for fabricating electrospun muscle dECM scaffolds that are effectively decellularized and retain key ECM components. We investigated the effects of fiber orientation and the degree of crosslinking on fiber swelling as well as bulk scaffold swelling, porosity, tensile properties, and degradation kinetics.…”

Section: Introductionmentioning

confidence: 99%

Fabrication and Characterization of Electrospun Decellularized Muscle-Derived Scaffolds

Smoak

Han

Watson

et al. 2019

Tissue Engineering Part C: Methods

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Although skeletal muscle has a high potential for self-repair, volumetric muscle loss can result in impairment beyond the endogenous regenerative capacity. There is a clinical need to improve on current clinical treatments that fail to fully restore the structure and function of lost muscle. Decellularized extracellular matrix (dECM) scaffolds have been an attractive platform for regenerating skeletal muscle, as dECM contains many biochemical cues that aid in cell adhesion, proliferation, and differentiation. However, there is limited capacity to tune physicochemical properties in current dECM technologies to improve outcome. In this study, we aim to create a novel, high-throughput technique to fabricate dECM scaffolds with tunable physicochemical properties while retaining proregenerative matrix components. We demonstrate a successful decellularization protocol that effectively removes DNA. We also identified key steps for the successful production of electrospun muscle dECM without the use of a carrier polymer; electrospinning allows for rapid scaffold fabrication with high control over material properties, which can be optimized to mimic native muscle. To this end, fiber orientation and degree of crosslinking of these dECM scaffolds were modulated and the corollary effects on fiber swelling, mechanical properties, and degradation kinetics were investigated. Beyond application in skeletal muscle, the versatility of this technology has the potential to serve as a foundation for dECM scaffold fabrication in a variety of tissue engineering applications.

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“…For example, the naturally occurring isomers of polyisoprene-natural rubber and gutta-percha-display stereochemically dependent thermomechanical properties where the cis orientation of the alkene moiety disrupts chain packing and leads to a much softer, more amorphous material 1,2 . Such striking structure-property relationships are often found in stereochemically precise biopolymers, e.g., collagen or elastin, but there remain significant limitations in synthetically mimicking these complex biological materials 3,4 . Achieving control over stereochemical assembly of monomers into synthetic polymers, particularly backbone stereochemistry, could afford a simple platform from which to access a diverse range of materials properties.…”

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confidence: 99%

Elastomeric polyamide biomaterials with stereochemically tuneable mechanical properties and shape memory

Worch

Weems

et al. 2020

Nat Commun

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Biocompatible polymers are widely used in tissue engineering and biomedical device applications. However, few biomaterials are suitable for use as long-term implants and these examples usually possess limited property scope, can be difficult to process, and are nonresponsive to external stimuli. Here, we report a class of easily processable polyamides with stereocontrolled mechanical properties and high-fidelity shape memory behaviour. We synthesise these materials using the efficient nucleophilic thiol-yne reaction between a dipropiolamide and dithiol to yield an α,β − unsaturated carbonyl moiety along the polymer backbone. By rationally exploiting reaction conditions, the alkene stereochemistry is modulated between 35-82% cis content and the stereochemistry dictates the bulk material properties such as tensile strength, modulus, and glass transition. Further access to materials possessing a broader range of thermal and mechanical properties is accomplished by polymerising a variety of commercially available dithiols with the dipropiolamide monomer.

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Elastic materials for tissue engineering applications: Natural, synthetic, and hybrid polymers

Cited by 124 publications

References 194 publications

Evaluation of an elastic decellularized tendon‐derived scaffold for the vascular tissue engineering application

Evaluation of an elastic decellularized tendon‐derived scaffold for the vascular tissue engineering application

Fabrication and Characterization of Electrospun Decellularized Muscle-Derived Scaffolds

Elastomeric polyamide biomaterials with stereochemically tuneable mechanical properties and shape memory

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