Elastic Light Tunable Tissue Adhesive Dendrimers

Gao, Feng; Djordjević, Ivan; Mogal, Vishal; O’Rorke, Richard; Pokholenko, Oleksandr; Steele, Terry W. J.

doi:10.1002/mabi.201600033

Cited by 53 publications

(79 citation statements)

References 52 publications

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“…Biomaterials with strong adhesive properties to wet tissues have emerged as promising strategies for sutureless wound closure following surgical procedures [49]. In this regard, in our previous studies, we demonstrated that GelMA-based hydrogels possess high adhesive strength to various physiological tissues, while also exhibiting superior mechanical performance when compared with commercially available tissue adhesives [37,50].…”

Section: Adhesive Properties Of Gelma/bio-il Cardiopatches To Physiolmentioning

confidence: 92%

Engineering a naturally-derived adhesive and conductive cardiopatch

et al. 2019

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Myocardial infarction (MI) leads to a multi-phase reparative process at the site of damaged heart that ultimately results in the formation of non-conductive fibrous scar tissue. Despite the widespread use of electroconductive biomaterials to increase the physiological relevance of bioengineered cardiac tissues in vitro, there are still several limitations associated with engineering biocompatible scaffolds with appropriate mechanical properties and electroconductivity for cardiac tissue regeneration. Here, we introduce highly adhesive fibrous scaffolds engineered by electrospinning of gelatin methacryloyl (GelMA) followed by the conjugation of a choline-based bio-ionic liquid (Bio-IL) to develop conductive and adhesive cardiopatches. These GelMA/Bio-IL adhesive patches were optimized to exhibit mechanical and conductive properties similar to the native myocardium. Furthermore, the engineered patches strongly adhered to murine myocardium due to the formation of ionic bonding between the Bio-IL and native tissue, eliminating the need for suturing. Co-cultures of primary cardiomyocytes and cardiac fibroblasts grown on GelMA/Bio-IL patches exhibited comparatively better contractile profiles compared to pristine GelMA controls, as demonstrated by over-expression of the gap junction protein connexin 43. These cardiopatches could be used to provide mechanical support and restore electromechanical coupling at the site of MI to minimize cardiac remodeling and preserve normal cardiac function.

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Section: Adhesive Properties Of Gelma/bio-il Cardiopatches To Physiolmentioning

confidence: 92%

Engineering a naturally-derived adhesive and conductive cardiopatch

et al. 2019

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“…Diazirine generates highly reactive carbene when irradiated with ultraviolet A (UVA, 365 nm) light, which can insert itself into most CH bonds . Polymer end‐modified with diazirine exhibited light‐initiated adhesion, effectively adhered PLGA films to biological tissues . The bulk mechanical property and adhesive property of the diazirine‐modified adhesive can be tuned by the dose of applied UVA.…”

Section: Multifunctional Biomedical Adhesivesmentioning

confidence: 99%

Multifunctional Biomedical Adhesives

Pinnaratip

Bhuiyan

Meyers

et al. 2019

Adv Healthcare Materials

143

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Currently available biomedical adhesives are mainly engineered to have one function (i.e., providing mechanical support for the repaired tissue). To improve the performance of existing bioadhesives and broaden their applications in medicine, numerous multifunctional bioadhesives are reported in the literature. These adhesives can be categorized as passive or active by design. Passive multifunctional bioadhesives contain inherent compositions and structural designs that can carry out additional functions without added external influences. These adhesives exhibit new functionalities such as antimicrobial properties, self‐healing abilities, the ability to promote cellular ingrowth, and the ability to be reshaped. Conversely, active multifunctional bioadhesives respond to environmental changes (e.g., pH, temperature, electricity, light, and biomolecule concentration), which initiate a change in the adhesive to release encapsulated drugs or to activate or deactivate the bioadhesive for interfacial binding. This review article highlights recent advances in multifunctional bioadhesives.

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“…By grafting TAD onto G5 PAMAM dendrimer, a model system is easily synthesized in a one‐step reaction to explore photochemical and bioadhesive structure–activity relationships. Previous investigations have explored PDz with respect to grafting/solid content, voltage‐activation, and non‐aqueous formulations . Previous studies have also focused on biocompatibility and cytotoxicity behavior of the primary components.…”

Section: Comparison Of Energy Generated Per Pulse Versus Required Actmentioning

confidence: 99%

Pulsed Laser Activation of Carbene Bioadhesive Boosts Bonding Strength

Shah

Kartheek

Gandhi

et al. 2019

Macro Materials & Eng

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Light‐activated tissue adhesives are limited to low light doses (50 J) and intensities (<1 W cm−2) due to photo‐to‐thermal heat generation. Low intensities have the disadvantage of limited penetration depths with retarded crosslinking kinetics, which impairs carbene‐based crosslinking strategies that compete with nitrogen evolution and gas nucleation. These limitations are circumvented by a trade‐off between high‐intensity activation while reducing the exposure surface area. Continuous or pulsed activation by line scanning the carbene precursor adhesive allows curing a higher surface area/volume ratio while preventing localized heat generation. By optimizing irradiation with a pulsed laser scan, the adhesion strength is improved by 17‐fold over ultraviolet A (UVA) light emitting diodes (LEDs) and is on par with bioadhesive gold standard of topical cyanoacrylates. Overall, this improved method of photo‐activation applies to other industrial and clinical photocuring adhesives where limits on UVA dose constrain exposure intensities.

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Elastic Light Tunable Tissue Adhesive Dendrimers

Cited by 53 publications

References 52 publications

Engineering a naturally-derived adhesive and conductive cardiopatch

Engineering a naturally-derived adhesive and conductive cardiopatch

Multifunctional Biomedical Adhesives

Pulsed Laser Activation of Carbene Bioadhesive Boosts Bonding Strength

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