Elastic compliance as a tool to understand Hofmeister ion specific effect in DMPC liposomes

A Novel Surfactant with Short Hydrophobic Head and Long Hydrophilic Tail Generates Vesicles with Unique Structural Feature

“…The electron density distribution in the present case has a similar pattern as observed previously for DMPC (1,2‐dimyristoyl‐ sn ‐glycerol‐3‐phosphocholine) liposomal vesicles of ≈100 nm diameter, where the lamellar spacing or bilayer thickness ( d ) is around 4.42 nm in which the length of a single phospholipid molecule is ≈2 nm. [ 39 ] The bilayer thickness of Fm‐GPO vesicles is longer as the length of the molecule is greater. The hydrophilic peptide tail regions have a higher electron density value than the hydrophobic region due to electron‐rich moieties like oxygen and nitrogen in the peptide and phosphate ions from the densely attached buffer medium.…”

“…The hydrophilic peptide tail regions have a higher electron density value than the hydrophobic region due to electron‐rich moieties like oxygen and nitrogen in the peptide and phosphate ions from the densely attached buffer medium. [ 39a ] The peptide chain exposed to the bulk solution has a higher electron density than the peptide chain directed inside the vesicle because of the more extensive availability of ions in the bulk solution. Such a pattern has been reported previously for liposomes.…”

“…Such a pattern has been reported previously for liposomes. [ 39a,40 ] To demonstrate the encapsulation potential of the Fm‐GPO vesicles, an uncharged phenoxazone dye, Nile red, was encapsulated using a reported method with slight modification. [ 41 ] On excitation of a solution containing Nile red‐encapsulated inside 1.56 mM Fm‐GPO vesicles (λ ex = 550 nm), maximum emission was observed around 578 nm (Figure 6d), as reported for other Nile red‐encapsulated systems.…”