Elastic Behavior of the Outer Hair Cell Wall

Steele, Charles R.

doi:10.1007/978-1-4757-4341-8_10

Cited by 4 publications

(2 citation statements)

References 10 publications

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“…In this study, the individual structural layers of the cell cortex are correlated with measured mechanical properties of the cell on the assumption that the mechanical properties of each layer ( Fig. 1) contribute to the stiffness of the entire cell cortex (Steele, 1990). The main aim was to test the idea that the cortical lattice is an orthotropic structure in which the longitudinal stiffness is significantly less than the circumferential stiffness (Holley and Ashmore, 1988a).…”

Section: Introductionmentioning

confidence: 99%

Mechanical properties of the lateral cortex of mammalian auditory outer hair cells

Tolomeo¹,

Steele²,

Holley³

1996

Biophysical Journal

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Mammalian auditory outer hair cells generate high-frequency mechanical forces that enhance sound-induced displacements of the basilar membrane within the inner ear. It has been proposed that the resulting cell deformation is directed along the longitudinal axis of the cell by the cortical cytoskeleton. We have tested this proposal by making direct mechanical measurements on outer hair cells. The resultant stiffness modulus along the axis of whole dissociated cells was 3 x 10(-3) N/m, consistent with previously published values. The resultant axial and circumferential stiffness moduli for the cortical lattice were 5 x 10(-4) N/m and 3 x 10(-3) N/m, respectively. Thus the cortical lattice is a highly orthotropic structure. Its axial stiffness is small compared with that of the intact cell, but its circumferential stiffness is within the same order of magnitude. These measurements support the theory that the cortical cytoskeleton directs electrically driven length changes along the longitudinal axis of the cell. The Young's modulus of the circumferential filamentous components of the lattice were calculated to be 1 x 10(7) N/m2. The axial cross-links, believed to be a form of spectrin, were calculated to have a Young's modulus of 3 x 10(6) N/m2. Based on the measured values for the lattice and intact cell cortex, an estimate for the resultant stiffness modulus of the plasma membrane was estimated to be on the order of 10(-3) N/m. Thus, the plasma membrane appears to be relatively stiff and may be the dominant contributor to the axial stiffness of the intact cell.

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Section: Introductionmentioning

confidence: 99%

Mechanical properties of the lateral cortex of mammalian auditory outer hair cells

Tolomeo¹,

Steele²,

Holley³

1996

Biophysical Journal

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“…It has been reported that electrostatic interactions among the ¢bers comprising the pillars could lead to changes in cell length (Steele, 1990). Furthermore, electrostatic interaction between stereocilia may in£uence the mechanical properties of the hair bundle (Dolgobrodov et al, 2000).…”

Section: The Speci¢c E¡ect Of L-argininementioning

confidence: 99%

The effect of L-arginine on slow motility of mammalian outer hair cell

Lin

Tan

et al. 2003

Hearing Research

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Detection without deflection? A hypothesis for direct sensing of sound pressure by hair cells

Bell

2007

J Biosci

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It is widely thought that organisms detect sound by sensing the deflection of hair-like projections, the stereocilia, at the apex of hair cells. In the case of mammals, the standard interpretation is that hair cells in the cochlea respond to deflection of stereocilia induced by motion generated by a hydrodynamic travelling wave. But in the light of persistent anomalies, an alternative hypothesis seems to have some merit: that sensing cells (in particular the outer hair cells) may, at least at low intensities, be reacting to a different stimulus - the rapid pressure wave that sweeps through the cochlear fluids at the speed of sound in water. This would explain why fast responses are sometimes seen before the peak of the travelling wave. Yet how could cells directly sense fluid pressure? Here, a model is constructed of the outer hair cell as a pressure vessel able to sense pressure variations across its cuticular pore, and this 'fontanelle' model, based on the sensing action of the basal body at this compliant spot, could explain the observed anomalies. Moreover, the fontanelle model can be applied to a wide range of other organisms, suggesting that direct pressure detection is a general mode of sensing complementary to stereociliar displacement.

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Elastic Behavior of the Outer Hair Cell Wall

Cited by 4 publications

References 10 publications

Mechanical properties of the lateral cortex of mammalian auditory outer hair cells

Mechanical properties of the lateral cortex of mammalian auditory outer hair cells

The effect of L-arginine on slow motility of mammalian outer hair cell

Detection without deflection? A hypothesis for direct sensing of sound pressure by hair cells

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