Elastic and hydrostatic behaviour of a zinc dietary supplement, zinc glycinate hydrate

Abstract

Coordination polymer based dietary supplement tablets are commonly consumed in our daily life and play an important role in the pharmaceutical industry.

Periodic DFT Calculations—Review of Applications in the Pharmaceutical Sciences

“…Such changes are of a decisive importance for the drugs' production and thanks to DFT calculations can be described and understood on the atomic level. As both temperature and pressure are imposed on the substances while the tableting process, it has in itself an immense influence on the tablet components state [115]. Under the applied conditions, a polymorphic transition may take place which can be predicted with DFT-methodology ( Figure 3) Figure 3.…”

High-pressure preference for reduced water content in porous zinc aspartate hydrates

“…Zinc plays a key role in the human body as a cofactor of numerous enzymes and it is therefore often included in dietary supplements and medicines for various illnesses (Shankar & Prasad, 1998;Haase et al, 2008;Roohani et al, 2013;Azeem et al, 2019). Zinc aspartate hydrate (ZnAsp 2 ÁnH 2 O, Asp denotes the aspartate anion; Fig.…”

Mechanical properties of coordination polymer-based dietary supplements

“…In terms of composition, CP-based dietary supplements have better bioactivity and less side-effects than conventional purely inorganic food supplements, and play a significant role in the food and pharmaceutical industry [10]. CP-based supplements and additives cover a wide range of materials, including calcium (e.g., calcium gluconate, calcium aspartate, calcium fumarate), copper (e.g., copper glycinate), magnesium (e.g., magnesium malate), zinc (e.g., zinc glycinate, zinc acetate), iron (e.g., ferrous fumarate), and potassium (e.g., potassium citrate) derivatives [9,[11][12][13][14][15].…”

“…However, comparing with the common pharmaceutical molecule drug crystals, food dietary supplements CPs present a significant lack of available knowledge on the elastic and plastic properties. Only few systematic studies involving zinc acetate dihydrate, zinc glycinate hydrate and calcium fumarate trihydrate have been investigated in the literatures [9,14,15]. It is worth noting that many CPs and coordination complexes (e.g., calcium gluconate [28], vitamin B 6 [29] and ferrous fumarate [28,30]) have been served as APIs in tablet form, for example, calcium gluconate (CHCaO) tablet is not only a mineral supplement and medication, but also used as a source of Ca 2+ ion to regulate the drug release with the change in the concentration of calcium gluconate in alginate matrix tablets [31].…”

“…[24], Copyright 2015, American Chemical Society. (c) Zinc and calcium dietary supplements (zinc acetate dehydrate, zinc glycinate hydrate and calcium fumarate trihydrate) [14,15]. Reproduced with permission from Ref.…”