1980
DOI: 10.1007/bf02001421
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Elastic and contractile properties of the myocardium in experimental cardiac hypertrophy of the rat Methodological and pathophysiological considerations

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Cited by 14 publications
(9 citation statements)
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“…The papillary muscle at the posterior wall was freed from thin fibrous filaments and excised after silk ligatures were fixed to both ends of the muscle. The muscle preparations were mounted in a previously described myograph using stainless steel hooks (13,14,15).…”
Section: Methodsmentioning
confidence: 99%
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“…The papillary muscle at the posterior wall was freed from thin fibrous filaments and excised after silk ligatures were fixed to both ends of the muscle. The muscle preparations were mounted in a previously described myograph using stainless steel hooks (13,14,15).…”
Section: Methodsmentioning
confidence: 99%
“…Whereas tissue distensibility is not decreased in hypertrophy due to swimming training or experimental hyperthyroidism, considerable changes have been described in chronic pressure overload, particularly in renal hypertension (7,14,15,16). However, the structural basis of passive elastic properties has not been definitively clarified, neither in normal nor in hypertrophied myocardium.…”
Section: Introductionmentioning
confidence: 95%
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“…The basic mechanisms, which govern the function of hypertrophied heart, are wen understood (30,31). As regards myofibrillar modulation of cardiac performance, the concept of polymorphic myosin provides a rational explanation of some until now rather empirical observations.…”
Section: The Myosin Isoenzyme Pattern and Myocardial Energeticsmentioning
confidence: 98%
“…Regression of hypertrophy in these models has been associated with increased (13) and normal collagen concentration (20). As emphasized by others (30,31), factors in addition to increased afterload may affect the myocardial changes that occur in these models and comparison to other models of pressure-induced hypertrophy may be inappropriate.…”
Section: Resultsmentioning
confidence: 95%