ELAM-1 Mediates Cell Adhesion by Recognition of a Carbohydrate Ligand, Sialyl-Le
            <sup>x</sup>

Phillips, M. L.; Nudelman, Edward; Gaeta, F. C. A.; Perez, Mary; Singhal, Anil; Hakomori, Sen‐itiroh; Paulson, James C.

doi:10.1126/science.1701274

Cited by 1,290 publications

(523 citation statements)

References 44 publications

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“…Phillips et al (1990) demonstrated that anti-sL x CSLEX mAb blocked adhesion of a human promyelocytic cell line to human endothelial cells. These results indicated the complexity of expression and function of sL x and sL a epitopes on the established cell lines.…”

Section: Clinicalmentioning

confidence: 99%

“…Such findings were not known when we had planned this prospective randomized control study. But now, it is known that sialyl Lewis-X (sL x ) and sialyl Lewis-A (sL a ) antigens are ligands to Eselectin, and sL x and sL a expressed on cancer cells mediate adhesion of the cancer cells to vascular endothelial cells expressing Eselectin (Phillips et al, 1990;Takada et al, 1991Takada et al, , 1993. The adhesion of cancer cells to vascular endothelial cells is a key step in invasion and metastasis of cancer cells (Hoff et al, 1989(Hoff et al, , 1990Nakamori et al, 1993).…”

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confidence: 99%

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Cimetidine increases survival of colorectal cancer patients with high levels of sialyl Lewis-X and sialyl Lewis-A epitope expression on tumour cells

et al. 2002

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Cimetidine has been shown to have beneficial effects in colorectal cancer patients. In this study, a total of 64 colorectal cancer patients who received curative operation were examined for the effects of cimetidine treatment on survival and recurrence. The cimetidine group was given 800 mg day 71 of cimetidine orally together with 200 mg day 71 of 5-fluorouracil, while the control group received 5-fluorouracil alone. The treatment was initiated 2 weeks after the operation and terminated after 1 year. Robust beneficial effects of cimetidine were noted: the 10-year survival rate of the cimetidine group was 84.6% whereas that of control group was 49.8% (P50.0001). According to our previous observations that cimetidine blocked the expression of E-selectin on vascular endothelium and inhibited the adhesion of cancer cells to the endothelium, we have further stratified the patients according to the expression levels of sialyl Lewis antigens X (sL x ) and A (sL a ). We found that cimetidine treatment was particularly effective in patients whose tumour had higher sL x and sL a antigen levels. For example, the 10-year cumulative survival rate of the cimetidine group with higher CSLEX staining, recognizing sL x , of tumours was 95.5%, whereas that of control group was 35.1% (P=0.0001). In contrast, in the group of patients with no or low levels CSLEX staining, cimetidine did not show significant beneficial effect (the 10-year survival rate of the cimetidine group was 70.0% and that of control group was 85.7% (P=n.s.)). These results clearly indicate that cimetidine treatment dramatically improved survival in colorectal cancer patients with tumour cells expressing high levels of sL x and sL a .

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Section: Clinicalmentioning

confidence: 99%

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confidence: 99%

Cimetidine increases survival of colorectal cancer patients with high levels of sialyl Lewis-X and sialyl Lewis-A epitope expression on tumour cells

et al. 2002

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“…Endothelial cell surface ICAM-1 is one of the ligands for neutrophil CD11/CD18, and mediates CD11/CD18-dependent adhesion to endothelium [18,29,30]. E-selectin recognizes Sialy-Lewis X, which is another neutrophil ligand [31]. Adhesion of neutrophils to E-selectin increases its CD11/CD18 expression, which in turn augments adhesion of neutrophils to endothelium [32].…”

Section: Discussionmentioning

confidence: 99%

Up-regulation of circulating adhesionmolecules in bronchiectasis

Zheng

Tipoe²,

Lam³

et al. 2000

Eur Respir J

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Adhesion molecules are expressed on the surface of endothelial cells and leukocytes and are responsible for mediating the migration of intravascular leukocytes into inflamed tissue. Intensive recruitment of neutrophils into the airways occurs in bronchiectasis, although little is known about the role of adhesion molecules in this process.The authors, therefore, determined serum levels of E-selectin, intercellular adhesion molecule (ICAM)-1 and vascular adhesion molecule (VCAM)-l in stable bronchiectasis patients (n=37) and healthy control subjects (n=17), and evaluated their relationship with clinical markers of disease severity in bronchiectasis.Serum levels of E-selectin, ICAM-1 and VCAM-1 in bronchiectasis patients were significantly higher than those in control subjects (p=0.02, <0.0001 and 0.0002 respectively). Both E-selectin and ICAM-1 levels were inversely related to forced expiratory volume in one second (FEV1)% predicted (r=-0.57, p<0.001; and r=-0.53, p=0.001 respectively), and FVC% predicted (r=-0.52, p=0.002; and r=-0.46, p=0.005). This was not the case for VCAM-1 levels. There was a correlation between serum ICAM-1 levels and 24 h sputum volume (r=0.34, p= 0.04). Serum E-selectin and ICAM-1, but not VCAM-1, levels showed correlation with the number of lung lobes affected by bronchiectasis (r=0.35, p=0.04 and r=0.34, p=0.04 respectively).These original observations strongly suggest that E-selectin, intercellular adhesion molecule-1 and Vascular adhesion molecule-1 could play a significant role in the pathogenesis of bronchiectasis. Eur Respir J 2000; 16: 691±696.

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“…Expression of E-selectin is induced on the cell surface of activated endothelial cells by key mediators of inflammation such as Il-1b and TNF-a (Bevilacqua et al, 1987) and has also been reported on the surface of tumour endothelial cells (Ye et al, 1995). Cell adhesion to E-selectin is mediated through the carbohydrate ligands sL X and sL A which are expressed predominantly on neutrophils (Phillips et al, 1990). In this way neutrophils can be recruited to sites of inflammation.…”

mentioning

confidence: 95%

Cimetidine in colorectal cancer – are the effects immunological or adhesion-mediated?

Eaton

Hawkins

2002

Br J Cancer

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ELAM-1 Mediates Cell Adhesion by Recognition of a Carbohydrate Ligand, Sialyl-Le ^x

Cited by 1,290 publications

References 44 publications

Cimetidine increases survival of colorectal cancer patients with high levels of sialyl Lewis-X and sialyl Lewis-A epitope expression on tumour cells

Cimetidine increases survival of colorectal cancer patients with high levels of sialyl Lewis-X and sialyl Lewis-A epitope expression on tumour cells

Up-regulation of circulating adhesionmolecules in bronchiectasis

Cimetidine in colorectal cancer – are the effects immunological or adhesion-mediated?

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ELAM-1 Mediates Cell Adhesion by Recognition of a Carbohydrate Ligand, Sialyl-Le x

Cited by 1,290 publications

References 44 publications

Cimetidine increases survival of colorectal cancer patients with high levels of sialyl Lewis-X and sialyl Lewis-A epitope expression on tumour cells

Cimetidine increases survival of colorectal cancer patients with high levels of sialyl Lewis-X and sialyl Lewis-A epitope expression on tumour cells

Up-regulation of circulating adhesionmolecules in bronchiectasis

Cimetidine in colorectal cancer – are the effects immunological or adhesion-mediated?

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Product

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ELAM-1 Mediates Cell Adhesion by Recognition of a Carbohydrate Ligand, Sialyl-Le ^x