ELAC2 polymorphisms and prostate cancer risk: a meta-analysis based on 18 case–control studies

Xu, Bin; Tong, Na; Jm, Li; Zd, Zhang; Wu, Huifeng

doi:10.1038/pcan.2010.6

Cited by 30 publications

(23 citation statements)

References 30 publications

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“…A meta-analysis showed that the Glu allele for the Asp541Glu polymorphism was associated with an increased risk in Caucasians[65], whereas a small Japanese study suggested a protective effect for Gln/Gln genotype[66]. Another meta-analysis on elaC homolog-2 ( ELAC2 ) gene/HPC2 at 17p11 indicated that the Ser allele of Ser217Leu and the Ala allele of the Ala541Thr polymorphisms significantly increased prostate cancer risk in Asians but had only marginal impact in Caucasians[67]. The Gln allele of the Arg399Gln polymorphism of the X-ray repair cross-complementing group 1 ( XRCC1 ) gene may be associated with a higher prostate cancer risk in Asians but not in Caucasians[68],[69].…”

Section: Nutrition Factors and Genetic Susceptibility Of Prostate Canmentioning

confidence: 99%

East meets West: ethnic differences in prostate cancer epidemiology between East Asians and Caucasians

Kimura¹

2012

Chin J Cancer

110

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Prostate cancer is the most prevalent cancer in males in Western countries. The reported incidence in Asia is much lower than that in African Americans and European Caucasians. Although the lack of systematic prostate cancer screening system in Asian countries explains part of the difference, this alone cannot fully explain the lower incidence in Asian immigrants in the United States and west-European countries compared to the black and non-Hispanic white in those countries, nor the somewhat better prognosis in Asian immigrants with prostate cancer in the United States. Soy food consumption, more popular in Asian populations, is associated with a 25% to 30% reduced risk of prostate cancer. Prostate-specific antigen (PSA) is the only established and routinely implemented clinical biomarker for prostate cancer detection and disease status. Other biomarkers, such as urinary prostate cancer antigen 3 RNA, may increase accuracy of prostate cancer screening compared to PSA alone. Several susceptible loci have been identified in genetic linkage analyses in populations of countries in the West, and approximately 30 genetic polymorphisms have been reported to modestly increase the prostate cancer risk in genome-wide association studies. Most of the identified polymorphisms are reproducible regardless of ethnicity. Somatic mutations in the genomes of prostate tumors have been repeatedly reported to include deletion and gain of the 8p and 8q chromosomal regions, respectively; epigenetic gene silencing of glutathione S-transferase Pi (GSTP1); as well as mutations in androgen receptor gene. However, the molecular mechanisms underlying carcinogenesis, aggressiveness, and prognosis of prostate cancer remain largely unknown. Gene-gene and/or gene-environment interactions still need to be learned. In this review, the differences in PSA screening practice, reported incidence and prognosis of prostate cancer, and genetic factors between the populations in East and West factors are discussed.

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Section: Nutrition Factors and Genetic Susceptibility Of Prostate Canmentioning

confidence: 99%

East meets West: ethnic differences in prostate cancer epidemiology between East Asians and Caucasians

Kimura¹

2012

Chin J Cancer

110

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“…For prostate cancer, the most intensively investigated associations have related to genes in the following pathways: adhesion molecules (CDH1); androgen metabolism (AR, ESR2, SRDA2,); angiogenesis (VEGF) angiotensin conversion (ACE); baseexcision repair (XRCC1); inflammation and immune response (IL8, IL10, MSR1, PTGS2, TNF); inhibition of cell growth (FGFR4, TGFB1, TGFBR1); insulin-like growth factor metabolism (IGF1, IGFBP3); one carbon metabolism (MTHFR, diverse genes139); oxidative response (MnSOD, hOGG1); substrate metabolism (CYP1A1, CYP3A4, CYP17, GSTM1, GSTT1, GSTP1, NAT1 and NAT2, UGT2B17); vitamin D metabolism (VDR); and, common variants of genes for which rare mutations are associated with increased cancer risk (ELAC/HPC2, RNASEL, TP53, MDM2,) [36][37][38][39][40][41][42][43][44][45][46][47][48][49][50]. In general, the results of candidate gene studies have been inconclusive, for reasons discussed in many interpretations [51,52].…”

Section: Role Of Single Nucleotide Polymorphismmentioning

confidence: 99%

Single Nucleotide Polymorphisms: A New Paradigm in Predicting the Risk of Prostate Cancer

Ghagane¹

2016

Cell Dev Biol

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Prostate cancer (PC) is a most important health care problem because of its high prevalence, health-related costs, and mortality. Even though most patients have clinically localized and indolent tumors at diagnosis, worldwide, this disease still holds second place in the leading causes of cancer deaths. Research on susceptibility genes is one of hot issues in risk factors of prostate cancer. Nevertheless, the confirmation of prostate cancer susceptibility genes has been challenging. Thus focusing on the increasing number of single nucleotide polymorphisms (SNPs) that have been suggested to be implicated in the development and progression of PC. While individual SNPs are only moderately associated with PC risk, in combination, they have a stronger association. Therefore, identification of numerous variations in genes and analysis of their effects may lead to a better understanding of their impact on gene function and health of an individual. This improved knowledge may provide a starting point for the development of new useful SNP markers for medical testing and a safer individualized medication to treat the most common devastating disorders. This will revolutionize the medical field in the future. To illustrate the effect of SNPs on gene function and phenotype, this review focuses on genetic susceptibility of prostate cancer and role of single nucleotide polymorphism and revealing the impact of SNPs on the development and progression of prostate cancer.

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“…The rs5030739 polymorphism of ELAC2 was one of the earliest candidates as a prostate cancer risk SNP [32] . Four studies investigated an association of rs5030739 with symptomatic BPH [33–36] .…”

Section: Evidence Synthesismentioning

confidence: 99%

Systematic Review and Meta-analysis of Candidate Gene Association Studies of Lower Urinary Tract Symptoms in Men

et al. 2014

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ContextAlthough family studies have shown that male lower urinary tract symptoms (LUTS) are highly heritable, no systematic review exists of genetic polymorphisms tested for association with LUTS.ObjectiveTo systematically review and meta-analyze studies assessing candidate polymorphisms/genes tested for an association with LUTS, and to assess the strength, consistency, and potential for bias among pooled associations.Evidence acquisitionA systematic search of the PubMed and HuGE databases as well as abstracts of major urologic meetings was performed through to January 2013. Case-control studies reporting genetic associations in men with LUTS were included. Reviewers independently and in duplicate screened titles, abstracts, and full texts to determine eligibility, abstracted data, and assessed the credibility of pooled associations according to the interim Venice criteria. Authors were contacted for clarifications if needed. Meta-analyses were performed for variants assessed in more than two studies.Evidence synthesisWe identified 74 eligible studies containing data on 70 different genes. A total of 35 meta-analyses were performed with statistical significance in five (ACE, ELAC2, GSTM1, TERT, and VDR). The heterogeneity was high in three of these meta-analyses. The rs731236 variant of the vitamin D receptor had a protective effect for LUTS (odds ratio: 0.64; 95% confidence interval, 0.49–0.83) with moderate heterogeneity (I2 = 27.2%). No evidence for publication bias was identified. Limitations include wide-ranging phenotype definitions for LUTS and limited power in most meta-analyses to detect smaller effect sizes.ConclusionsFew putative genetic risk variants have been reliably replicated across populations. We found consistent evidence of a reduced risk of LUTS associated with the common rs731236 variant of the vitamin D receptor gene in our meta-analyses.Patient summaryCombining the results from all previous studies of genetic variants that may cause urinary symptoms in men, we found significant variants in five genes. Only one, a variant of the vitamin D receptor, was consistently protective across different populations.

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ELAC2 polymorphisms and prostate cancer risk: a meta-analysis based on 18 case–control studies

Cited by 30 publications

References 30 publications

East meets West: ethnic differences in prostate cancer epidemiology between East Asians and Caucasians

East meets West: ethnic differences in prostate cancer epidemiology between East Asians and Caucasians

Single Nucleotide Polymorphisms: A New Paradigm in Predicting the Risk of Prostate Cancer

Systematic Review and Meta-analysis of Candidate Gene Association Studies of Lower Urinary Tract Symptoms in Men

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