Elaboration of the SPM template for the standardization of SPECT images with 123I-Ioflupane

García-Gómez, Francisco Javier; García-Solís, David; Luis-Simón, F.J.; Marín-Oyaga, V.; Carrillo, Fátima; Mir, Pablo; Vázquez-Albertino, R.

doi:10.1016/j.remnie.2013.09.003

Cited by 35 publications

(26 citation statements)

References 11 publications

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“…were masked out for both molecular atlases as they were used as reference regions for the quantification of the molecular data in the kinetic models for the radioligands. For more details on the molecular templates, please refer to [45,46].…”

Section: Resultsmentioning

confidence: 99%

“…For the analysis with REACT, we used molecular templates of the DAT and NET systems. The DAT map is a publicly available template of 123 I-Ioflupane SPECT images (https://www.nitrc.org/projects/spmtemplates) from 30 HC without evidence of nigrostriatal degeneration [45]. The NET atlas was obtained by averaging the [ 11 C]MRB PET brain parametric maps from an independent dataset of 10 HC (33.3 +/-10 years, four women).…”

Section: Population-based Molecular Templatesmentioning

confidence: 99%

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Unravelling the effects of methylphenidate on the dopaminergic and noradrenergic functional circuits

Dipasquale

Martins

Sethi

et al. 2020

Neuropsychopharmacol.

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Functional magnetic resonance imaging (fMRI) can be combined with drugs to investigate the system-level functional responses in the brain to such challenges. However, most psychoactive agents act on multiple neurotransmitters, limiting the ability of fMRI to identify functional effects related to actions on discrete pharmacological targets. We recently introduced a multimodal approach, REACT (Receptor-Enriched Analysis of functional Connectivity by Targets), which offers the opportunity to disentangle effects of drugs on different neurotransmitters and clarify the biological mechanisms driving clinical efficacy and side effects of a compound. Here, we focus on methylphenidate (MPH), which binds to the dopamine transporter (DAT) and the norepinephrine transporter (NET), to unravel its effects on dopaminergic and noradrenergic functional circuits in the healthy brain at rest. We then explored the relationship between these target-enriched resting state functional connectivity (FC) maps and inter-individual variability in behavioural responses to a reinforcement-learning task encompassing a novelty manipulation to disentangle the molecular systems underlying specific cognitive/behavioural effects. Our main analysis showed a significant MPH-induced FC increase in sensorimotor areas in the functional circuit associated with DAT. In our exploratory analysis, we found that MPH-induced regional variations in the DAT and NET-enriched FC maps were significantly correlated with some of the inter-individual differences on key behavioural responses associated with the reinforcement-learning task. Our findings show that main MPH-related FC changes at rest can be understood through the distribution of DAT in the brain. Furthermore, they suggest that when compounds have mixed pharmacological profiles, REACT may be able to capture regional functional effects that are underpinned by the same cognitive mechanism but are related to engagement of distinct molecular targets.

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Section: Resultsmentioning

confidence: 99%

Section: Population-based Molecular Templatesmentioning

confidence: 99%

Unravelling the effects of methylphenidate on the dopaminergic and noradrenergic functional circuits

Dipasquale

Martins

Sethi

et al. 2020

Neuropsychopharmacol.

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“…103 patients had a high-resolution Magnetization Prepared Rapid Gradient Echo (MPRAGE) 3DT1brain scan performed on 3.0 Tesla MR system (Magnetom Trio, Siemens, Erlangen Germany) as part of our clinical routine protocol (256 × 256 matrix, 176 sections, 1 × 1 × 1 mm 3 , TE = 2.3 ms, TR = 2300 ms). This subsample was used to build a 123 I-ioflupane SPECT template in Montreal Neurological Institute (MNI) standard space as described earlier ( Badoud et al, 2016 , García-Gómez et al, 2013 ).…”

Section: Methodsmentioning

confidence: 99%

“…We used a 123 I-ioflupane SPECT template in Montreal Neurological Institute (MNI) standard space as described earlier ( Badoud et al, 2016 , García-Gómez et al, 2013 ) in an automatic and operator-independent workflow. Due to the asymmetrical degeneration of the nigrostriatal pathways in PD and APS, we decided to flip all patients presenting predominant clinical symptoms on the left side of the body in order to obtain a more homogeneous sample with dominant symptomatology always at the same hemisphere.…”

Section: Methodsmentioning

confidence: 99%

Discriminating among degenerative parkinsonisms using advanced 123 I-ioflupane SPECT analyses

Badoud

Ville

Nicastro

et al. 2016

NeuroImage: Clinical

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123I-ioflupane single photon emission computed tomography (SPECT) is a sensitive and well established imaging tool in Parkinson's disease (PD) and atypical parkinsonian syndromes (APS), yet a discrimination between PD and APS has been considered inconsistent at least based on visual inspection or simple region of interest analyses. We here reappraise this issue by applying advanced image analysis techniques to separate PD from the various APS.This study included 392 consecutive patients with degenerative parkinsonism undergoing 123I-ioflupane SPECT at our institution over the last decade: 306 PD, 24 multiple system atrophy (MSA), 32 progressive supranuclear palsy (PSP) and 30 corticobasal degeneration (CBD) patients. Data analysis included voxel-wise univariate statistical parametric mapping and multivariate pattern recognition using linear discriminant classifiers.MSA and PSP showed less ioflupane uptake in the head of caudate nucleus relative to PD and CBD, yet there was no difference between MSA and PSP. CBD had higher uptake in both putamen relative to PD, MSA and PSP. Classification was significant for PD versus APS (AUC 0.69, p < 0.05) and between APS subtypes (MSA vs CBD AUC 0.80, p < 0.05; MSA vs PSP AUC 0.69 p < 0.05; CBD vs PSP AUC 0.69 p < 0.05).Both striatal and extra-striatal regions contain classification information, yet the combination of both regions does not significantly improve classification accuracy.PD, MSA, PSP and CBD have distinct patterns of dopaminergic depletion on 123I-ioflupane SPECT. The high specificity of 84–90% for PD versus APS indicates that the classifier is particularly useful for confirming APS cases.

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“…For the main analyses, cerebellum-corrected Ki values were extracted from a striatal region of interest defined independently from an [ 18 F]DOPA PET template normalized to MNI space (García-Gómez et al, 2013). In order to improve sensitivity, we retained the template voxels in which Ki values exceeded the mean Ki value across all voxels by at least 3 standard deviations ( Figure 1A).…”

Section: Pet Data Preprocessing and Analysesmentioning

confidence: 99%

Spontaneous eye blink rate and dopamine synthesis capacity: Preliminary evidence for an absence of positive correlation

Sescousse

Ligneul

Holst

et al. 2017

Preprint

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Dopamine is central to a number of cognitive functions and brain disorders. Given the cost of neurochemical imaging in humans, behavioral proxy measures of dopamine have gained in popularity in the past decade, such as spontaneous eye blink rate (sEBR). Increased sEBR is commonly associated with increased dopamine function based on pharmacological evidence and patient studies. Yet, this hypothesis has not been validated using in vivo measures of dopamine function in humans. In order to fill this gap, we measured sEBR and striatal dopamine synthesis capacity using [ 18 F]DOPA PET in 20 participants (9 healthy individuals and 11 pathological gamblers). Our results, based on frequentist and Bayesian statistics, as well as region-of-interest and voxel-wise analyses, argue against a positive relationship between sEBR and striatal dopamine synthesis capacity. They show that, if anything, the evidence is in favor of a negative relationship. These results, which complement findings from a recent study that failed to observe a relationship between sEBR and dopamine D2 receptor availability, suggest that caution and nuance are warranted when interpreting sEBR in terms of a proxy measure of striatal dopamine.

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Elaboration of the SPM template for the standardization of SPECT images with 123I-Ioflupane

Cited by 35 publications

References 11 publications

Unravelling the effects of methylphenidate on the dopaminergic and noradrenergic functional circuits

Unravelling the effects of methylphenidate on the dopaminergic and noradrenergic functional circuits

Discriminating among degenerative parkinsonisms using advanced 123 I-ioflupane SPECT analyses

Spontaneous eye blink rate and dopamine synthesis capacity: Preliminary evidence for an absence of positive correlation

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