Elaboration of Submicron Particles for Biomedical Imaging and Drug Delivery: Specific Review

Iqbal, Muhammad Tajwar; Fessi, Hatem; Elaı̈ssari, Abdelhamid

doi:10.1166/jcsb.2016.1131

Cited by 2 publications

(2 citation statements)

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“…These nanovectors are used as X-ray contrast agents, as surface-enhanced Raman spectroscopy (SERS) enablers, and in radiotherapy enhancement . Polymeric nanoparticles and micelles are also used as probes for imaging and carriers for theranostics because of their high drug payload and scalability, sustained release of the drug, low-cost production, low batch variability, easier tenability, and degradation properties. , The usage of polymeric micelles is helpful because of their ability to entrap contrast agents and hydrophobic drugs, preserving their hydrophilic characteristics as carriers, compared to soluble polymers or liposomes . Liposomes, artificially generated vesicles, have essentially been examined as vehicles for the delivery of drugs following their favorable invulnerable profile.…”

Section: Nanovectors In Theranosticsmentioning

confidence: 99%

“…28,29 The usage of polymeric micelles is helpful because of their ability to entrap contrast agents and hydrophobic drugs, preserving their hydrophilic characteristics as carriers, compared to soluble polymers or liposomes. 30 Liposomes, artificially generated vesicles, have essentially been examined as vehicles for the delivery of drugs following their favorable invulnerable profile. Multifunctional nanovectors have been created, with liposomes encapsulating contrast agents for the instantaneous release of drug and early diagnosis of a disease.…”

Section: ■ Nanovectors In Theranosticsmentioning

confidence: 99%

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Magnetic Nanoparticles: From Synthesis to Theranostic Applications

Khizar

Ahmad

Zine

et al. 2021

ACS Appl. Nano Mater.

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Over the past few years, engineered inorganic nanoparticles have been studied researched, and applied extensively in the biomedical field since resultant platforms increase the usage of the nanoparticles for particular theranostic applications. The innovation of such nanosystems has the potential to develop a theranostic mode that integrates both diagnosis and treatment of diseases in a particular system via combinatorial approaches of imaging, targeting, and therapy that accomplish the potential of personalized and tailored medicine. The manipulation of magnetic nanoparticles (MNPs) as theranostic agents have attained growing consideration in material science owing to their exclusive capability in magnetic targeting, magnetic resonance imaging, chemotherapy, hyperthermia, bioseparation, gene therapy, enzyme immobilization, and controlled release of the drug. To intensify the diagnostic and therapeutic efficacy, MNPs have been ornamented or functionalized with a range of materials to enhance the biocompatibility, stability, and capability to carry therapeutic payloads and to encapsulate imaging agents. Preferentially synthetic and natural polymers have been exploited to coat for ensuring their colloidal stability and good dispersibility in biological fluids. Stimuli-responsive polymers have also been used to functionalize MNPs to establish a therapeutic approach that can significantly enhance therapeutic effectiveness including the real-time monitoring in specific cells and tissues. The present review highlights the progress of MNPs emphasizing functionalization using diverse inorganic and organic and biomaterials. Furthermore, it also provides the soundproof concept on the potential of MNPs and their colloidal counterparts that offer attractive possibilities for theranostic applications. Finally, the main challenges and limitations in the use of MNPs for advanced biomedical applications have also been critically provided.

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