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Rakhimov, K; Karimov, O. R.; Kurbanov, A. S.; Kuchkarova, Lubov Salijanovna

doi:10.1023/a:1016558421099

Cited by 4 publications

(2 citation statements)

References 8 publications

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“…During the fetal and neonatal periods, intestinal luminal digestion is generally low due to the immature stomach and pancreatic function and the presence of milk-borne protease inhibitors (27,55,133). The reduced luminal enzymatic activity during these periods functions to keep molecules intact until they reach the intestinal epithelium, thus preserving antigenicity and possibly increasing the extent of their subsequent transepithelial passage (134). Antenatally, components in the amniotic fluid like proteinase inhibitors, and, postnatally, bioactive components in colostrum and milk, will influence the luminal environment and hence the formation and stability of antigenic molecules.…”

Section: Gut Luminal Effects On Antigen Transfermentioning

confidence: 99%

The Immature Gut Barrier and Its Importance in Establishing Immunity in Newborn Mammals

et al. 2020

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Section: Gut Luminal Effects On Antigen Transfermentioning

confidence: 99%

The Immature Gut Barrier and Its Importance in Establishing Immunity in Newborn Mammals

et al. 2020

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“…Maturation of the gut is characterized by increased digestive capacity at weaning with resultant changes in the properties of brush border enzymes and pancreatic enzyme secretion (Henning, 1981;Rakhimov et al, 2002). PHA administration stimulated increased trypsin (Sureda et al, 2018), maltase and sucrase activities (Prykhod'ko et al, 2009) and an adult-like disaccharidase pattern (Linderoth et al, 2005) in suckling rats, prior to weaning.…”

Section: Impact Of Medicinal Plants and Phytochemicals On The Development And Maturation Of The Gastrointestinal Tractmentioning

confidence: 99%

Medicinal Plants, Phytochemicals, and Their Impacts on the Maturation of the Gastrointestinal Tract

et al. 2021

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The gastrointestinal tract (GIT) is the first point of contact for ingested substances and thus represents a direct interface with the external environment. Apart from food processing, this interface plays a significant role in immunity and contributes to the wellbeing of individuals through the brain-gut-microbiota axis. The transition of life from the in utero environment, to suckling and subsequent weaning has to be matched by phased development and maturation of the GIT; from an amniotic fluid occupancy during gestation, to the milk in the suckling state and ultimately solid food ingestion at weaning. This phased maturation of the GIT can be affected by intrinsic and extrinsic factors, including diet. Despite the increasing dietary inclusion of medicinal plants and phytochemicals for health benefits, a dearth of studies addresses their impact on gut maturation. In this review we focus on some recent findings mainly on the positive impact of medicinal plants and phytochemicals in inducing precocious maturation of the GIT, not only in humans but in pertinent animals. We also discuss Paneth cells as mediators and potential markers of GIT maturation.

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Early effects on the intestinal barrier and pancreatic function after enteral stimulation with protease or kidney bean lectin in neonatal rats

2018

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Gut maturation naturally accelerates at weaning in altricial mammalian species, such as the rat. Mimicking this, gut development can also be induced precociously, 3-4 d earlier than it would occur naturally, by enteral exposure to phytohaemagglutinin (PHA), or various proteases. We investigated the early effects of gut provocation on intestinal barrier and pancreatic functions, to get a better understanding of the mechanisms that initiate gut maturation. The effects of oral administration of protease (trypsin) or PHA to 14-d-old suckling rats were studied during 24 h in comparison with water-fed controls. Intestinal in vivo permeability was assessed by oral administration of different-sized marker molecules and measuring their passage into the blood or urine 3 h later. A period of 24 h following oral administration, both PHA and protease provocation stimulated small intestinal (SI) growth and pancreatic secretion, as indicated by decreased pancreatic trypsin and increased luminal enzyme content. Within 1 h of oral administration, both treatments prevented the absorption of macromolecules to blood that was observed in controls. PHA treatment hindered the passage of fluorescein isothiocyanate-dextran (FD) 4 to blood, whereas protease treatment temporarily increased plasma levels of FD4, and the urine lactulose:mannitol ratio, indicating increased intestinal leakiness. Following protease treatment, fluorescence microscopy showed decreased vesicular uptake of FD70 in the proximal SI and increased epithelial fluorescence in the distal SI. In conclusion, PHA and protease differed in their early effects on the intestinal barrier; both exerted a blocking effect on epithelial endocytosis, whereas protease treatment alone temporarily increased epithelial leakiness, which seemed to be confined to the distal SI.

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Cited by 4 publications

References 8 publications

The Immature Gut Barrier and Its Importance in Establishing Immunity in Newborn Mammals

The Immature Gut Barrier and Its Importance in Establishing Immunity in Newborn Mammals

Medicinal Plants, Phytochemicals, and Their Impacts on the Maturation of the Gastrointestinal Tract

Early effects on the intestinal barrier and pancreatic function after enteral stimulation with protease or kidney bean lectin in neonatal rats

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