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Abstract

Various kinds of hyperthermic treatment for malignant glioma had been inhibited due to both their incomplete feverish action and strict cooling effect of the brain. The author shows an effective results of hyperthermia for the treatment of malignant glioma in an in vivo study using stick type carboxymethylcellulose (CMC)-magnetite, a newly manufactured magnetite-product. A stick type CMC-magnetite, containing magnetite particles, was inserted into the T-9 glioma in the rat brain stereotactically, and the rats were exposed to an alternative magnetic field (AMF). The application time of AMF, which measured 88.9 kHz and 380 Oe, was 30 min a day. The rats were divided into three groups: three AMF applications (group I), one AMF application (group II) and no application but only injection of CMC-magnetite (control). As a result, the mean survival in days of these three groups measured 44.2+/-10.9 (group I), 17.0+/-1.5 (group II) and 14.4+/-1.5 (control). This investigation showed both significant effectiveness in attacking malignant glioma and significant prolonging of the survival time in rats. It is also a characteristic feature of the magnetite particles to spread through the tumor diffusely after three applications of AMF. This feature seemed to be one of the main factors that caused greater hyperthermic effect on glioma in this study. This method of hyperthermic treatment could be a useful strategy in the treatment of malignant glioma.

Enhanced antitumor efficacy of biocompatible magnetosomes for the magnetic hyperthermia treatment of glioblastoma

“…Compared with previous preclinical studies showing increased survival by 15-44 days of rats bearing RG-2 or T-9 glioma tumors and treated by magnetic hyperthermia at 43-47 ºC, 59 , 60 , our study reports for the first-time full cure of subcutaneous GL-261 tumors in a significant percentage of mice (50%) using biocompatible nanoparticles synthesized biologically by magnetotactic bacteria with improved properties, compared with previously used chemically synthesized nanoparticles.…”

Magnetic hyperthermia therapy for the treatment of glioblastoma: a review of the therapy’s history, efficacy and application in humans

“…The same group then utilised stick type carboxymethylcellulose (CMC) magnetite to test MHT efficacy in an orthotopic rat glioma model [104]. The temperature of the tissue beneath the scalp was measured with a fibre optic probe.…”

Intriguing Properties and Applications of Functional Magnetic Materials

“…MNs are the nanoparticles synthesized from magnetic elements like iron, nickel, and cobalt or their chemical derivatives [21][22][23][24][25][26]. Each particle of bulk magnetic materials has many domains separated by walls, and each domain represents a region with a specific direction of magnetization.…”

“…Recently, thermotherapy for cancer using MN has emerged as a potential mode of hyperthermia [23][24][25][26]. Hyperthermia is a type of medical treatment in which body tissue is exposed to a temperature (42-44°C) higher than physiological temperature (37°C) to kill the cancer cells.…”