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Abstract

During the 6-year period (January 1, 1993 to December 31, 1998) in the Laboratory for Dermatopathology of Department of Dermatovenereology in Clinical Hospital Split, 1616 basal cell carcinomas (BCC) of a total of 323 investigated specimens were diagnosed. The incident rate varies from 92 to 114 BCC per 100,000 inhabitants in the Split region. The sex ratio in material is 1.2:1 in favor of males. The frequence of BCC increases with the advanced age in both sexes with the peak in the age group from 70 to 79 years. The most frequent location in both sexes is the nose followed by cheeks and trunk. Statistic analysis showed a significantly higher occurrence of BCC in temporal region in the males and perioral region in the females; respectively. The solid variant is the most frequent followed by superficial multicentric and solid-adenoid. Pure variants are found in 83.1% specimens, and mixed variants in 16.9%. Solid and adenoid variants are the most frequent on the nose and cheeks. According to statistics cystic variant is significantly higher on the forehead, and morpheic variant on the nose. Superficial multicentric variant is statistically more frequent on the trunk than on other locations. All specimens were reexamined and histopathologic variants were obtained. Over 2000 data are comprised which is a sufficient examination sample. In programs such as SPSS, and Graph master ver 1.12, Win95, MO'97 (Word, Excel, Access) on Pentium II 200 MHz, floppy, 64 MB RAM, HDD 2.1 GB, CD x24, HP LJet 6L, a comprehensive analysis has been performed.

Histopathological evaluation of non-melanoma skin cancer

“…Weedon [3] and Haws and colleagues [27] opined that the mixed type is most frequently seen, but a study showed that the solid variant is most frequently seen [28], and superficial multicentric and solid-adenoid variants were observed. Puizina-Ivić and colleagues observed pure and mixed variants at a rate of 83.1% and 16.9%, respectively [28]. Nakjang and Kullavanijaya [29] opined that pigmentation was most frequently seen in solid, superficial and adenoid subtypes.…”

A novel anti‐ageing mechanism for retinol: induction of dermal elastin synthesis and elastin fibre formation

“…Anti-ageing skin care treatments range from cosmetic preparations, fillers and neurotoxins, to surgical intervention and laser skin resurfacing [46,47]. However, adverse effects have been associated with many of these methods, and the desire for safe and effective products that reduce wrinkles and improve skin elasticity remains high.…”

Cigarette smoke-induced early growth response-1 regulates the expression of the cysteine-rich 61 in human skin dermal fibroblasts

“…Smoking is associated with several dermatologic conditions, including psoriasis, wound healing, premature skin ageing, squamous cell carcinoma, melanoma, oral cancer, acne, eczema and hair loss (12). Findings from a recent research study clearly demonstrated that tobacco smoking is another environmental factor contributing to premature ageing (13). 'Smoker's face' and 'cigarette skin', meaning increased facial wrinkling and an ashen and grey skin appearance, are characteristic (14).…”