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Chen, W.; Li, J.; Liu, L.; Zeng, Jia; Yu, Ying; Zhang, Z.

doi:10.1023/a:1025082106781

Cited by 3 publications

(1 citation statement)

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“…in order to obtain reproducible, catalyst-and impurity-free product applicable in biological experiments. For example, purification performed in acids such as HCl [6], HNO 3 [7] or H 2 SO 4 [8] can significantly alter the nanotube chemistry (side wall attachment of functional groups) and its size (tube cleavage) distribution. These modifications alter the attributes of the substrate, ultimately affecting the response of the biological host.…”

Section: Introductionmentioning

confidence: 99%

The chemical and physical characteristics of single-walled carbon nanotube film impact on osteoblastic cell response

Tutak¹,

Chhowalla²,

Sesti³

2010

Nanotechnology

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Carbon-nanotube-based substrates have been shown to support the growth of different cell types and, as such, have raised considerable interest in view of their possible use in biomedical applications. Nanotube matrices are embedded in polymers which cause inherent changes in nanotube chemical and physical film properties. Thus, it is critical to understand how the physical properties of the film affect the biology of the host tissue. Here, we investigated how the physical and chemical properties of single-walled carbon nanotubes (SWNT) films impact the response of MC3T3-E1 bone osteoblasts. We found that two fundamental steps in cell growth-initial attachment to the substrate and proliferation-are strongly dependent on, respectively, the energy and roughness of the surface. Thus, fine-tuning the properties of the film may represent a valid strategy to optimize the response of the biological host.

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Section: Introductionmentioning

confidence: 99%