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Pivovarov, A. S.; Nistratova, V. L.

doi:10.1023/a:1026390117562

Cited by 5 publications

(7 citation statements)

References 3 publications

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“…These results correlate with the data of Glanzman et al ( 1989 ) which show the inhibition of the heterosynaptic facilitation in Aplysia by the neurotoxin 5,7-DHT. Data from the literature (Pivovarov and Nistratova, 2003 ; Abramova et al, 2005 ) and our results show that premotor interneurons respond to 5-HT, i.e., 5-HT may modulate the behavioral effects. Direct evidence of the possibility of electrophysiological modulatory effects of the serotonergic neuron Pd4 on the premotor interneuron LPa3 was found by Balaban et al ( 2001 ).…”

Section: Discussionsupporting

confidence: 75%

“…For example, the facilitation action on reflex activity and on central pattern generators (Gillette, 2006 ). The increase in excitability of neurons under the action of 5-HT has been noted by a number of authors (Frysztak and Crow, 1997 ; Liao et al, 1999 ; Balaban et al, 2001 ; Pivovarov and Nistratova, 2003 ; Abramova et al, 2005 ; Dumitriu et al, 2006 ; Hawkins et al, 2006 ). Jin and co-authors have shown that 5-HT increases the peak amplitude of the complex excitatory post-synaptic potential induced by light, and also increases the internal excitability and the spike activity of type Ie(A) interneurons of the mollusk Hermissenda (Jin et al, 2009 ).…”

Section: Discussionmentioning

confidence: 76%

“…They demonstrated that only NAN-190 (a 5-HT 1A -receptor antagonist) and methiothepin (a 5-HT 1E receptor antagonist) inhibited the development of the 5-HT effect. The results show the presence of 5-HT receptors but only of the first type on the soma of Helix premotor interneurons (Pivovarov and Nistratova, 2003 ; Abramova et al, 2005 ).…”

Section: Discussionmentioning

confidence: 87%

“…These common effects suggest that they are related to the effects of 5-HT on receptors located on the membrane of premotor interneurons and possibly on the intermediate neurons that are presynaptic to premotor interneurons. Pivovarov and Nistratova ( 2003 ) analyzed the possible presence of 5-HT receptors on the soma of snail's premotor interneurons. 5-HT, applied locally to the soma, reversibly decreased the input current caused by acetylcholine (local ionophoretical application).…”

Section: Discussionmentioning

confidence: 99%

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Modulation of defensive reflex conditioning in snails by serotonin

Андрианов

Bogodvid

Deryabina

et al. 2015

Front. Behav. Neurosci.

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Highlights Daily injection of serotonin before a training session accelerated defensive reflex conditioning in snails.Daily injection of 5-hydroxytryptophan before a training session in snails with a deficiency of serotonin induced by the “neurotoxic” analog of serotonin 5,7-dihydroxytryptamine, restored the ability of snails to learn.After injection of the “neurotoxic” analogs of serotonin 5,6- and 5,7-dihydroxytryptamine as well as serotonin, depolarization of the membrane and decrease of the threshold potential of premotor interneurons was observed.We studied the role of serotonin in the mechanisms of learning in terrestrial snails. To produce a serotonin deficit, the “neurotoxic” analogs of serotonin, 5,6- or 5,7-dihydroxytryptamine (5,6/5,7-DHT) were used. Injection of 5,6/5,7-DHT was found to disrupt defensive reflex conditioning. Within 2 weeks of neurotoxin application, the ability to learn had recovered. Daily injection of serotonin before a training session accelerated defensive reflex conditioning and daily injections of 5-HTP in snails with a deficiency of serotonin induced by 5,7-DHT restored the snail's ability to learn. We discovered that injections of the neurotoxins 5,6/5,7-DHT as well as serotonin, caused a decrease in the resting and threshold potentials of the premotor interneurons LPa3 and RPa3.

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Section: Discussionsupporting

confidence: 75%

Section: Discussionmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Modulation of defensive reflex conditioning in snails by serotonin

Андрианов

Bogodvid

Deryabina

et al. 2015

Front. Behav. Neurosci.

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“…It was also shown that antagonist of 5-HT receptors mianserin blocked two forms of withdrawal behavior of Lymnaea caused by an unconditioned stimulus (extract of crayfish tissue), and another 5-HT receptor antagonist methylsergide blocked formation of the long-term memory after training (Il-Han et al, 2010 ). The 5-HT 1 receptors were described for the soma of identified premotor interneurons of the terrestrial snail, which are the object of our study (Pivovarov and Nistratova, 2003 ; Abramova et al, 2006 ).…”

Section: Introductionmentioning

confidence: 92%

Responses of Withdrawal Interneurons to Serotonin Applications in Naïve and Learned Snails Are Different

Bogodvid

Андрианов

Deryabina

et al. 2017

Front. Cell. Neurosci.

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Long-term changes in membrane potential after associative training were described previously in identified premotor interneurons for withdrawal of the terrestrial snail Helix. Serotonin was shown to be a major transmitter involved in triggering the long-term changes in mollusks. In the present study we compared the changes in electrophysiological characteristics of identifiable premotor interneurons for withdrawal in response to bath applications of serotonin (5-HT) or serotonin precursor 5-hydroxytryptophan (5-HTP) in preparations from naïve, neurotoxin-injected or associatively trained snails. It was found that 5-HT or 5-HTP applications caused a significant decrease of membrane potential in premotor interneurons of naïve snails, associatively trained snails and snails with impaired serotonergic system by injection of a selective neurotoxin 5,7-dihydroxytryptamine (5,7-DHT) 1 week before the experiments. Applications of 5-HT or 5-HTP did not cause significant changes in the action potential (AP) threshold potential of these neurons in naïve snails. Conversely, applications of 5-HT or 5-HTP to the premotor interneurons of previously trained or 5,7-DHT-injected snails caused a significant increase in the firing threshold potential in spite of a depolarizing shift of the resting membrane potential. Results demonstrate that responsiveness of premotor interneurons to extracellularly applied 5-HT or 5-HTP changes for days after the associative training or serotonin depletion. Similarity of the effects in trained and 5,7-DHT-injected animals may be due to massive release of serotonin elicited by 5,7-DHT injection. Our results suggest that serotonin release due to aversive conditionining or elicited by the neurotoxin administration triggers similar changes in resting membrane potential and AP threshold in response to bath applications of 5-HT or its precursor 5-HTP.

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