El resurgimiento del metoxiflurano en México

Abstract

RESUMEN.El metoxiflurano es un anestésico halogenado que se utilizó hace varias décadas para anestesia general balanceada y que actualmente está indicado para otorgar sedación controlada por el paciente. Este medicamento se encuentra actualmente a la venta en la República Mexicana, por lo que recordar las características que lo hacen diferente a otros halogenados, su farmacocinética y su utilidad para distintos escenarios proporciona el conocimiento adecuado para su uso en la práctica clínica. ABSTRACT.Methoxyflurane is a halogenated anesthetic that was used decades ago for a balanced general anesthesia and is currently indicated for patient-controlled sedation. This drug is currently on sale in the Mexican Republic, so remembering the characteristics that make it different from other halogenated drugs, its pharmacokinetics and its usefulness for different scenarios provides knowledge for use in clinical practice.

Implementation of Inhaled Methoxyflurane for the Reduction of Distal Radius Fractures in a Third-Level Hospital: A Descriptive Cohort Study

“…However, a retrospective comparative observational study with a followup of up to 14 years did not show an increased risk of liver or kidney disease in patients who received methoxyflurane as a low-dose analgesic [13,14]. The low concentrations at which it is administered usually keep the patients conscious and rarely require airway manipulation, unlike deep intravenous sedation [13][14][15]. These are the doses administered to the group whose fractures were reduced with this anesthetic without the presence of pain.…”

“…However, the duration of followup is limited, and the number of hepatic and renal events reported in routine pharmacovigilance is too small to draw reliable conclusions. However, a retrospective comparative observational study with a followup of up to 14 years did not show an increased risk of liver or kidney disease in patients who received methoxyflurane as a low-dose analgesic [13,14]. The low concentrations at which it is administered usually keep the patients conscious and rarely require airway manipulation, unlike deep intravenous sedation [13][14][15].…”